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Enter a new era of sensitivity and LC-MS/MS innovation with the SCIEX Triple Quad™ 7500 LC-MS/MS System - QTRAP® Ready. GO BEYOND current limits of sensitivity, productivity targets, ruggedness and robustness challenges. Pioneer new discoveries with this innovation.

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Incomparable

Experience extraordinary sensitivity gains from the SCIEX 7500 System. Start detecting the previously undetectable, and quantify at lower levels with impressive precision.

Ingenious

Expand your laboratory capabilities to test dirty and complex samples. The new D Jet™ Ion Guide will allow you to characterize analytes that were once masked by matrices.

Productive

Quantify more trace analytes at lower levels. Simplify sample prep, and inject less sample using the OptiFlow® Pro Ion Source. And also boost the transition of crucial ions into the system with the integrated E Lens™ Technology.

INCOMPARABLE

The SCIEX 7500 System delivers the highest level of sensitivity of all the SCIEX systems. Significant gains have been made in the analysis of key analytes that demand lower limits of quantification. The innovation in this product enables low level quantification of crude and complex samples to further your research. Plus expand and simplify your workflow with a linear dynamic range up to six orders magnitude.

INGENIOUS

The Turbo V™ Ion Source has evolved. The OptiFlow Pro Ion Source incorporated into the SCIEX 7500 System enables analytes in crude or complex samples to be detected. The OptiFlow Pro Source contains E Lens Technology, which improves the transfer of ions into the mass spectrometer. The modularity of the OptiFlow Pro Source enables the easy interchange from high flow to low flow and between ESI and APCI, quickly. Increase the sensitivity of your assay with the SCIEX 7500 System to gain a more accurate profile of your sample. The increased size of the orifice allows more ions into the mass spectrometer and the unique design of the D Jet Ion Guide retains and captures more of the ions from the ESI spray plume.

PRODUCTIVE

Move your workflow to this highly sensitive instrument and quickly see measurable gains in productivity. With innovation that enables you to test more samples, and detect trace compounds that previously could not be seen by any SCIEX system. The SCIEX 7500 System is powered by SCIEX OS Software, a platform for this next generation of mass spectrometers. Traditional software features and functions are complemented by visual aids and components to enable quick, accurate and confident data review.

SCIEX OS SOFTWARE

Analyze and represent your data in a new and intuitive format. Control, acquire, analyze, interrogate and report, all on one software platform.

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Enabling new levels of quantification
Using the SCIEX 7500 System, powered by SCIEX OS Software.

QTRAP® Ready

With a simple upgrade path this system can offer additional QTRAP functionality scan types. Pairing conventional MRM workflows and Enhanced Product Ion scans can enable improved confidence in acquired data. MRM3 workflows can push quantification levels through matrix interferences.

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E LENS TECHNOLOGY

Get a stronger gradient around the orifice and protect your precious and limited sample. With the E Lens Technology, the power and efficiency of the SCIEX Turbo V Ion Source geometry is enhanced in the new OptiFlow Pro Source, which focuses transmission of the ESI plume into the orifice of the system.

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IONIZATION SOURCE

Execute fast interchanges between high flow and low flow to adapt to your workflow needs. The OptiFlow Pro Source introduces a new modularity feature and incorporates the reliability and efficiency of the legendary Turbo V Ion Source.

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D JET™ ION GUIDE

Capture more of the ESI plume and retain more of the important ions than with previous technologies. The D Jet Ion Guide concentrates the samples and removes the gas molecules and neutral ions.

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DETECTION

Attain lower levels of quantification compared to other SCIEX instruments. The precise and robust engineering of the ion rail allows consistent and reproducible analysis time after time, by focusing the crucial ions that you need for your workflow.

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E LENS™ TECHNOLOGY

IONIZATION SOURCE

D JET™ ION GUIDE

DETECTION

QTRAP® Ready

Therapeutics are always going to be necessary...Now with this new SCIEX 7500 System, we have another level of sensitivity. SCIEX has again set the bar.

SHANE NEEDHAM
Chief Founding Scientist
Alturas Analytics, Moscow, ID

You have to look for different substances in water and some substances are very difficult to measure because of the sensitivity of current instruments. Before now we didn’t know they were in the water because the methods weren’t sensitive enough.

BERNARD BAJEMA
Project Leader
Vitens, Netherlands

The drive to improve pesticide detection limits is not just from legislation, but also from the demands of consumers. Faster and more sensitive technology prepares us for those situations to allow us to get lower and we will if required.

WIM BROER
Manager, Science and Development
Nofalab, Netherlands

When an instrument is sensitive, we can do direct water injection. We don’t need sample prep to concentrate the samples, that is the big advantage of sensitive machines.

RONNY BOSCH
Senior Analyst
Vitens, Netherlands

SENSITIVITY GAINS FOR THE EVOLUTION OF ROUTINE BIOANALYSIS

The rapid advancement of the drug pipeline demands sensitivity to allow a more complete pharmacokinetic characterization of low-dose drug candidates, below detection limits. The SCIEX 7500 System will enable pharmaceutical researchers to continue to explore lower dosage, higher efficacy compounds, and improve the efficiency of routine bioanalysis.

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IMPROVED SENSITIVITY IN IN-VITRO TRANSPORTER ASSAYS

In drug discovery, being able to make pharmacologically relevant measurements of drug candidates and evaluate the transporter at early-stage development is crucial when selecting drug safety profiles. The 7500 System offers you enhanced sensitivity to reduce compound concentrations, so it’s more biologically relevant. Download the technical note to see how you can get higher-quality data.

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HIGH SENSITIVITY PEPTIDE QUANTIFICATION WORKFLOW

Quantification of peptide/protein therapeutics in biological matrices is crucial for therapeutic development. Download the technical note that demonstrates a robust method using the SCIEX 7500 System to quantify a series of surrogate peptides in rat plasma at ultra-low LLOQs —5 to 39 fmol/mL.

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ULTRA-SENSITIVE QUANTIFICATION OF INTACT PEPTIDE HORMONE IN RAT PLASMA

Quantifying intact peptide hormone analogs is challenging for because of low ionization and CID fragmentation efficiency related to the high molecular weights, low concentrations in matrices that require ultra-high assay sensitivity, and endogenous inferences from natural intact peptide hormones. Enter the SCIEX 7500 System. Read more about the sensitive LC-MRM method to quantify intact peptide hormones in rat plasma.

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IMPROVED LC-MRM WORKFLOW FOR CYCLIC PEPTIDE QUANTIFICATION ON NATRIURETIC PEPTIDE FAMILY

Quantifying trace level cyclic peptides in biological matrices is extremely challenging. The SCIEX 7500 System can offer outstanding reproducibility, precision, accuracy, and linearity to ease these challenges. Download this ultra-sensitive MRM based cyclic peptide quantification workflow.

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ENHANCING THE SENSITIVITY OF PEPTIDE QUANTIFICATION FOR THE TARGETED HOST CELL PROTEINS ANALYSIS

There are important requirements for the quantitative measurement of host cell proteins (HCP) across the entire development paradigm. Learn about the targeted high sensitivity, analysis throughput, robustness and multiplexing capability approach using the SCIEX 7500 System.

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BROAD LIPID QUANTIFICATION USING A HIGH- THROUGHPUT TARGETED LIPIDOMICS METHOD

The complexity of the lipidome is very high with a huge diversity in lipid molecular species making comprehensive quantitative profiling challenging. Download this technical note to find out about a targeted MRM assay approach which enables quantification of a broad array of different lipids at the molecular species level using the SCIEX 7500 System.

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REPRODUCIBLE TARGETED PEPTIDE PROFILING USING HIGHLY MULTIPLEXED MRM ASSAYS

Quantitative robustness remains key, to ensure both large and small biological changes are accurately measured across large sample cohorts. The SCIEX 7500 System offers you high sensitivity as well as wide linear dynamic range for large scale targeted peptide quantification.

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HIGHLY-SENSITIVE PESTICIDE ANALYSIS IN BABY FOOD

Detecting and quantifying pesticide residues in food remains a moving target as food regulations drive the pursuit of lower limits of quantification. This work demonstrates the high sensitivity of the SCIEX 7500 System in quantifying 209 pesticides, easily achieving sub-ppb detection limits with a very small injection volume.

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PRECISE TESTING OF PESTICIDES IN FOOD USING THE SCIEX 7500 SYSTEM

The global scale of pesticide use, its impact on food safety and authenticity regulations have led to the need for sensitivity analysis that can achieve trace levels. Download the technical note to learn more about how the SCIEX 7500 System offers sensitivity, robustness and accuracy with 700 compounds achieving limits low as 0.2 ng/mL.

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THE DIRECT AQUEOUS ANALYSIS OF PESTICIDES AND PPCP's, IN DRINKING AND BOTTLED WATER USING THE SCIEX 7500 SYSTEM

Drinking water analysis is subjected to extremely low and rigid prescribed consent values (PCV) for determinands, including pesticides, pharmaceuticals and personal care products. In collaboration with Vitens Water Company, we demonstrated the sensitivity levels of the SCIEX 7500 System for low-level quantification across a relatively large suite of 431 determinands.

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FUTURE-PROOFING CANNABIS ANALYSIS WITH THE SCIEX 7500 SYSTEM

As the cannabis market emerges globally, more stringent and lower level pesticide regulations may come into force. The SCIEX 7500 System shows its levels of sensitivity across a broad suite of regulated pesticides coupled with ruggedness and robustness for continued analysis of cannabis extracts.

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HIGH-SENSITIVITY DETECTION OF FORENSIC DRUG PANEL IN HUMAN WHOLE BLOOD

In a forensic laboratory, the ability to accurately quantify large panels of analytes in complex biological matrices over a wide range of concentration is challenging and often requires dilution of the samples to bring them within the calibration range of the instrument. In this technical note, the SCIEX 7500 System demonstrates exceptional performance in speed, linear dynamic range and sensitivity to overcome this challenge, quantifying a panel of 49 drugs in human whole blood.

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ULTRA-SENSITIVE ANALYTICAL METHODOLOGY FOR THE QUANTIFICATION OF 11-NOR-9-CARBOXY-THC (THC-COOH) IN ORAL FLUID

The detection and quantification of THC in drug screening can result in a high number of false positives since this analyte can be found in subjects passively exposed to cannabis. The SCIEX 7500 System offers you high sensitivity, robustness and performance to accurately quantify pg/mL levels of THC-COOH in oral fluid; without the need for derivatization.

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