Explore the potential of trusted LC-MS/MS solutions designed to simplify and accelerate biomarker quantitation. Bring drug candidates through the development pipeline more efficiently and confidently with accurate results obtained using innovative hardware and software, lab-tested methods and expert support.
Biomarker quantitation
Overview
No matter where you are in the drug development process, SCIEX supports your analytical workflows with LC-MS solutions on a single software platform.
Discover innovative instruments and software with robust and sensitive performance for enabling new discoveries.
Small biomarkers
Workflow
Our systems provide in-depth coverage that enables you to characterize and confidently quantify biomarkers, even low abundant ions. With different technology options for specific needs, SCIEX can help you get the answers you need.
- Achieve confident answers in hours instead of days
- Confidently characterize and quantify small biomarkers with robust, sensitive analyses
- Improve workflows with support from our dependable team of experts
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
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SCIEX 7500 system
Detect the previously undetectable and quantify at lower levels than ever before with impressive precision.
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SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
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Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
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Featured resources
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Technical note
High sensitivity quantitation of acylcarnitines using the SCIEX 7500 system
Learn how to achieve high sensitivity and reproducibility with a simple sample preparation method and a fast LC gradient with 8 carnitine and acylcarnitine biomarkers monitored in rat plasma.
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Technical note
Sensitive bioanalysis of galactosyl sphingosine (GalSPH) and glucosyl sphingosine (GluSPH) in cerebral spinal fluid
Sensitivity for 2 glycosphingolipids (GluSPH and GalSPH) was evaluated in cerebral spinal fluid using the SCIEX 7500 system. An assay was developed using HILIC chromatography along with positive MRM analysis and electrospray ionization. Calibration curves were generated on the SCIEX 7500 system and the QTRAP 6500+ system to assess the sensitivity difference.
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Technical note
Identification and quantitation of lipid biomarkers using accurate mass spectrometry
We demonstrate a combination of qualitative and quantitative workflows to identify and quantify lipid biomarkers in a mouse brain matrix.
Small biomarkers
Suited for:
- Easily identifying and quantifying unknown analytes
- Analyzing even difficult-to-fragment analytes with alternative fragmentation technology
- Exploring complex matrices and samples with higher selectivity needs
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
ZenoTOF 7600 system
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Learn more
SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
Large biomarkers
Workflow
Discover better analytical solutions that meet your needs for in-depth coverage with robust and sensitive performance. Confidently characterize and quantify large-molecule biomarkers—including low-abundant ions—faster than ever before with easy-to-use, integrated software. All of our solutions are complemented by dependable access to an expert support team eager to help you improve your workflows and move promising candidates forward.
- Achieve confident answers in hours instead of days
- Confidently characterize and quantify large biomarkers with robust, sensitive analyses
- Supported by dependable service support
Large biomarkers
Suited for:
- Easily identifying and quantifying unknown analytes
- Analyzing even difficult-to-fragment analytes with alternative fragmentation technology
- Exploring complex matrices and samples with higher selectivity needs
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
ZenoTOF 7600 system
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Learn more
SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
SCIEX 7500 system
Detect the previously undetectable and quantify at lower levels than ever before with impressive precision.
Learn more
SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
All resources
-
Technical note
High sensitivity quantitation of acylcarnitines using the SCIEX 7500 system
Learn how to enable high sensitivity and reproducibility with a simple sample preparation method and a fast LC gradient with 8 carnitine and acylcarnitine biomarkers monitored in rat plasma.
-
Technical note
Sensitive bioanalysis of galactosyl sphingosine (GalSPH) and glucosyl sphingosine (GluSPH) in cerebral spinal fluid
Sensitivity for 2 glycosphingolipids (GluSPH and GalSPH) was evaluated in cerebral spinal fluid using the SCIEX 7500 system. An assay was developed using HILIC chromatography along with positive MRM analysis and electros
-
Technical note
Identification and quantitation of lipid biomarkers using accurate mass spectrometry
We demonstrate a combination of qualitative and quantitative workflows to identify and quantify lipid biomarkers in a mouse brain matrix.
-
Technical note
Sensitive multiplexed quantitation of protein biomarkers for early drug discovery and development
Dive into a new solution for highly sensitive quantitation of surfactant proteins in human plasma at a signature peptide level with low-ng/mL lower limits of quantitation.
Associated applications
Biomarker discovery
Confidently discover, quantify and translate previously inaccessible and challenging biomarkers with solutions designed to facilitate in-depth, comprehensive analysis.
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