Confidently discover, quantify and translate previously inaccessible and challenging biomarkers with solutions designed to facilitate in-depth, comprehensive analysis.
Biomarker discovery
Explore the latest and trending topics
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Video
The right treatment | SCIEX Stories
Get insight from Tony Whetton of the University of Surrey on a new strategy for finding a cure for leukemia. Learn how proteomics, mass spectrometry and informatics can be used to make precision medicine a reality for today and the future.
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Video
Multi-omics drug discovery | SCIEX Stories
See how a multi-omics approach to drug discovery is helping scientists at the John van Geest Cancer Research Centre better understand epithelial-mesenchymal transition (EMT) and identify new therapeutic targets for metastatic prostate cancer.
Overview
Open up biomarker discovery with a new depth of proteomics knowledge and help make disease characterization possible at earlier stages. Discover biomarkers that can guide early treatment of diseases with next-generation and targeted proteomics knowledge, and gain confidence in your results from drug discovery through translational research and beyond.
Biomarker discovery
Workflow
Discover, quantify and translate previously unknown biomarkers by uncovering unique fragmentation patterns and low-abundance species. Work with SCIEX experts to develop integrated analytical systems and novel methods for biomarker discovery that make new treatments for diseases possible at earlier stages.
- Discover novel biomarker candidates that facilitate drug discovery and development
- Perform large-scale experiments with powerful, high-throughput workflows and solutions
- Uncover candidate biomarker signatures with high sensitivity, robustness and reproducibility
Solution
Biomarker discovery
Suited for:
- Qualitative flexibility combined with quantitative power
- Precise perspectives on the proteome
ZenoTOF 7600 system
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Learn more
SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Learn more
Featured resources
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Technical note
High-throughput LC-MS/MS stratification of the plasma proteome response to SARS-CoV-2 infection
Learn how plasma protein quantitation could potentially enable better disease management and prognosis for patients with COVID-19 infections.
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Technical note
High-throughput quantitative proteomics using Zeno SWATH DIA and the Evosep One system
Find out how data-independent acquisition (DIA) using the ZenoTOF 7600 system enables fast quantitative proteomics.
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Technical note
Analysis of post-translational modifications using fast, tunable electron activated dissociation (EAD)
The unique electron activated dissociation (EAD) cell enables fast and reproducible fragmentation, even for peptides with large post-translational modifications (PTMs). Tuneability within the EAD cell further ensures that critical MS/MS information is retained for PTM characterization with high confidence.
Biomarker validation
Workflow
Leverage state-of-the-art, high-throughput solutions to facilitate large scale validation of candidate biomarkers whether batch-to-batch or sample-to-sample. With reliable and robust performance, and expert-level support services for faster analyses and nanoscale-level sensitivity, SCIEX enables accurate identification and quantitation.
- Identify and quantify biomarkers accurately and consistently
- Confidently validate candidate biomarkers with large-scale comparisons
- Establish fast, highly sensitive, robust and reproducible biomarker validation workflows
Solution
Biomarker validation
Suited for:
- Qualitative flexibility combined with quantitative power
- Precise perspectives on the proteome
ZenoTOF 7600 system
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Learn more
SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Learn more
Featured resources
-
Technical note
Sensitive bioanalysis of galactosylsphingosine (GalSph) and glucosylsphingosine (GlcSph) in cerebral spinal fluid
Learn how high-sensitivity LC-MS/MS enables quantitation of the structurally isomeric biomarkers glucosylsphingosine (GlcSph) and galactosylsphingosine (GalSph) in cerebral spinal fluid, even at very low levels.
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Poster
Reproducible targeted peptide profiling using highly multiplexed MRM assays
See how multiple reaction monitoring (MRM) provides accurate measurements of small and large biological changes across large and varying sample cohorts to support faster microflow chromatography runs.
Translational medicine
Workflow
Discover the next biomarkers that will drive improvements in human health using state-of-the-art technologies that provide nanoscale-level sensitivity for fast and accurate identification and quantitation. Rely on solutions that couple innovative hardware with versatility in data processing so you can quickly find the right compound to move forward with in vivo testing and validation in the clinical environment.
- Perform large-scale comparisons to identify the most promising compounds for drug development
- Enable fast, accurate identification and quantification using sensitive, robust and reproducible technologies
Solution
Translational medicine
Suited for:
- Qualitative flexibility combined with quantitative power
- Precise perspectives on the proteome
ZenoTOF 7600 system
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Learn more
SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Learn more
Features resources
-
Article
Drug discovery is a team sport
Small-molecule drug discovery in academia is all about teamwork. Learn from Florence Raynaud of the Institute for Cancer Research how LC-MS helps her team find suitable small-molecule candidates for in vivo testing.
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Blog
Improving patient care through translational mass spectrometry
Learn why the Citrine system is a go-to solution at Wake Forest School of Medicine for creating new rapid, accurate and reliable analytical methods for clinical applications.
-
Technical note
High-throughput quantitative proteomics using Zeno SWATH DIA and the Evosep One system
Take advantage of data-independent acquisition (DIA) with Zeno SWATH DIA using the ZenoTOF 7600 system and the Evosep One liquid chromatography system for fast, quantitative proteomics.
All resources
Filter:
-
Technical note
High-throughput LC-MS/MS stratification of the plasma proteome response to SARS-CoV-2 infection
Learn how plasma protein quantitation could potentially enable better disease management and prognosis for patients with COVID-19 infections.
-
Technical note
High-throughput quantitative proteomics using Zeno SWATH DIA and the Evosep One systemFind out how data-independent acquisition (DIA) using the ZenoTOF 7600 system enables fast quantitative proteomics.
Find out how data-independent acquisition (DIA) using the ZenoTOF 7600 system enables fast quantitative proteomics.
-
Technical note
Analysis of post-translational modifications using fast, tunable electron activated dissociation (EAD)
Discover how quickly electron activated dissociation (EAD) can reproducibly fragment peptides with post-translational modifications (PTMs) while retaining critical MS/MS information for PTM identification.
-
Technical note
Sensitive bioanalysis of galactosylsphingosine (GalSph) and glucosylsphingosine (GlcSph) in cerebral spinal fluid
Learn how high-sensitivity LC-MS/MS enables quantitation of the structurally isomeric biomarkers glucosylsphingosine (GlcSph) and galactosylsphingosine (GalSph) in cerebral spinal fluid, even at very low levels.
-
Technical note
Reproducible targeted peptide profiling using highly multiplexed MRM assays
See how multiple reaction monitoring (MRM) provides accurate measurements of small and large biological changes across large and varying sample cohorts to support faster microflow chromatography runs.
-
Article
Drug discovery is a team sport
Small-molecule drug discovery in academia is all about teamwork. Learn from Florence Raynaud of the Institute for Cancer Research how LC-MS helps her team find suitable small-molecule candidates for in vivo testing.
-
Blog
Improving patient care through translational mass spectrometry
Learn why the Citrine system is a go-to solution at Wake Forest School of Medicine for creating new rapid, accurate and reliable analytical methods for clinical applications.
-
Technical note
High-throughput quantitative proteomics using Zeno SWATH DIA and the Evosep One system
Take advantage of data-independent acquisition (DIA) with Zeno SWATH DIA using the ZenoTOF 7600 system and the Evosep One liquid chromatography system for fast, quantitative proteomics.
Associated applications
Biomarker quantitation
Explore the potential of trusted LC-MS/MS solutions designed to simplify and accelerate biomarker quantitation. Bring drug candidates through the development pipeline more efficiently and confidently with accurate results obtained using innovative hardware and software, lab-tested methods and expert support.
Learn more