Targeted protein degraders and PROTACs

Drug the previously un-druggable, backed by data-driven decisions.

Empower your team with the reliable and sensitive data they need to research targeted protein degraders.

Overview

Develop sensitive assays using advanced analytical systems that reliably detect low-pg/mL concentrations of highly potent targeted protein degraders, all while simplifying data acquisition.

SCIEX helps you confidently detect targeted protein degraders down to the smallest details. With high-sensitivity analytical systems and seamless data processing, you get fast, clear answers, so nothing stands between you and your next breakthrough.

Targeted protein degrader quantitation

Workflow

Develop sensitive assays using enhanced analytical systems that reliably detect nanomolar concentrations of highly potent targeted protein degraders. Achieve lower limits of quantitation (LLOQs) at the low-pg/mL level for the detection of targeted protein degraders in complex matrices with strong linearity and excellent accuracy and precision. Get to the important information quickly with fast, intuitive and integrated data acquisition and processing software.

  • When every data point counts, reach low-pg/mL detection limits with accuracy and precision.
  • Detect low-pg/mL concentrations of targeted protein degraders, even in complex matrices.
  • Compliance-ready software. One software platform, for peace of mind.
  • Service support goes beyond troubleshooting; SCIEX is your dedicated partner, ensuring reliable performance and expert guidance when you need it most.

Solution

Targeted protein degrader quantitation

ExionLC AE system

Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.

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SCIEX 7500+ Triple Quad system – QTRAP ready

Setting a new standard for instrument resilience and robustness, the SCIEX 7500+ system gives you the confidence to face evolving analytical challenges. Tackle tight timelines with exceptional sensitivity and with the power to control your instrument downtime.

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SCIEX OS software

Unleash the analytical power of the next-generation software platform for data acquisition and processing.

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Service

Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.

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Targeted protein degrader quan/qual

Workflow

Overcome challenges associated with detecting low levels of large targeted protein degraders active in complex matrices or limited sample quantities. Working with advanced mass spectrometry solutions enables your team to achieve high levels of sensitivity, ensure robust performance and streamline data management. High mass accuracy and MS/MS sensitivity over a wide mass range allows the use of simple sample preparation.

  • Achieve high accuracy and sensitivity over a wide mass range
  • Realize robust analytical performance across a broad linear dynamic range
  • Gain the analytical flexibility to support each process

Solution

Targeted protein degrader quan/qual

ExionLC AE system

Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.

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ZenoTOF 7600 system

A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.

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SCIEX OS software

Unleash the analytical power of the next-generation software platform for data acquisition and processing.

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Service

Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.

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Associated applications

Metabolite identification

Advance your drug discoveries with reliable metabolite data that save time and money. Our range of solutions supports routine monitoring and complex identification.

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