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Targeted protein degraders and PROTACs

Easily advance your targeted protein degraders and proteolysis targeting chimeras (PROTACs) with reliable and sensitive analytical data. Give your team the confidence to develop synthetic therapeutics with the support of the SCIEX technical team.

Overview

Lead the development of novel targeted protein degradation (TPD) therapeutics such as proteolysis targeting chimeras (PROTACs). Bring novel drugs based on this new class of compounds to market with analytical systems that enable precise and accurate identification and quantitation of low-level targeted protein degraders, even in complex matrices.

Targeted protein degrader quantitation

Workflow

Develop sensitive assays using enhanced analytical systems that reliably detect nanomolar concentrations of highly potent targeted protein degraders. Achieve lower limits of quantitation (LLOQs) at the low-pg/mL level for the detection of targeted protein degraders in complex matrices with strong linearity and excellent accuracy and precision. Get to the important information quickly with fast, intuitive and integrated data acquisition and processing software.

  • Achieve low-pg/mL quantitation of targeted protein degraders with excellent accuracy and precision
  • Detect nanomolar concentrations of targeted protein degraders, even in complex matrices

Solution

Targeted protein degrader quantitation

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ExionLC AE system

Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.

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SCIEX 7500 system

Detect the previously undetectable and quantify at lower levels than ever before with impressive precision.

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SCIEX OS software

Unleash the analytical power of the next-generation software platform for data acquisition and processing.

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Service

Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.

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Targeted protein degrader quan/qual

Workflow

Overcome challenges associated with detecting low levels of large targeted protein degraders active in complex matrices or limited sample quantities. Working with advanced mass spectrometry solutions enables your team to achieve high levels of sensitivity, ensure robust performance and streamline data management. High mass accuracy and MS/MS sensitivity over a wide mass range allows the use of simple sample preparation.

  • Achieve high accuracy and sensitivity over a wide mass range
  • Realize robust analytical performance across a broad linear dynamic range
  • Gain the analytical flexibility to support each process

Solution

Targeted protein degrader quan/qual

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ExionLC AE system

Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.

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ZenoTOF 7600 system

A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.

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SCIEX OS software

Unleash the analytical power of the next-generation software platform for data acquisition and processing.

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Service

Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.

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