Easily advance your targeted protein degraders and proteolysis targeting chimeras (PROTACs) with reliable and sensitive analytical data. Give your team the confidence to develop synthetic therapeutics with the support of the SCIEX technical team.
Targeted protein degraders and PROTACs
Overview
Lead the development of novel targeted protein degradation (TPD) therapeutics such as proteolysis targeting chimeras (PROTACs). Bring novel drugs based on this new class of compounds to market with analytical systems that enable precise and accurate identification and quantitation of low-level targeted protein degraders, even in complex matrices.
Targeted protein degrader quantitation
Workflow
Develop sensitive assays using enhanced analytical systems that reliably detect nanomolar concentrations of highly potent targeted protein degraders. Achieve lower limits of quantitation (LLOQs) at the low-pg/mL level for the detection of targeted protein degraders in complex matrices with strong linearity and excellent accuracy and precision. Get to the important information quickly with fast, intuitive and integrated data acquisition and processing software.
- Achieve low-pg/mL quantitation of targeted protein degraders with excellent accuracy and precision
- Detect nanomolar concentrations of targeted protein degraders, even in complex matrices
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
SCIEX 7500 system
Detect the previously undetectable and quantify at lower levels than ever before with impressive precision.
Learn more
SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
Featured resources
-
Technical note
Low-pg/mL quantitation of TL 13-112, a proteolysis targeting chimera (PROTAC) in rat plasma
Discover a highly sensitive assay for the quantitation of PROTACs in a complex matrix. Learn how innovative front-end enhancements achieved quantitation at low-pg/mL for a PROTAC and its inactive control in rat plasma.
-
Technical note
Sensitive analysis of the proteolysis targeting chimera (PROTAC) degrader ARV-110 in rat plasma
Find out how PROTACs in complex matrices can be detected with high levels of sensitivity using a triple quadrupole mass spectrometer with enhanced ion generation, capture and transmission.
Targeted protein degrader quan/qual
Workflow
Overcome challenges associated with detecting low levels of large targeted protein degraders active in complex matrices or limited sample quantities. Working with advanced mass spectrometry solutions enables your team to achieve high levels of sensitivity, ensure robust performance and streamline data management. High mass accuracy and MS/MS sensitivity over a wide mass range allows the use of simple sample preparation.
- Achieve high accuracy and sensitivity over a wide mass range
- Realize robust analytical performance across a broad linear dynamic range
- Gain the analytical flexibility to support each process
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
ZenoTOF 7600 system
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Learn more
SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
All resources
-
Technical note
Low-pg/mL quantitation of TL 13-112, a proteolysis targeting chimera (PROTAC) in rat plasma
Discover a highly sensitive assay for the quantitation of PROTACs in a complex matrix. Learn how quantitation at low-pg/mL levels was achieved for a PROTAC and its inactive control in rat plasma with innovative front-end
-
Technical note
Sensitive analysis of the proteolysis targeting chimera (PROTAC) degrader ARV-110 in rat plasma
Find out how PROTACs in complex matrices can be detected with high levels of sensitivity using a triple quadrupole mass spectrometer with enhanced ion generation, capture and transmission.
-
Technical note
A sensitive method for the quantitation of the proteolysis targeting chimera (PROTAC) TL 13-12 in rat plasma
Discover a sensitive and robust method for accurate quantitation of large PROTACs and their inactive controls in complex matrices. Learn about MRMHR workflow solutions with improved MS/MS sampling efficiency.
-
Webinar
Sensitive LC-MS/MS approach for the quantification of proteolysis targeting chimeras in a biological matrix
Webinar