Biologics Explorer software
Visualize with confidence. Interpret with clarity.
Biologics Explorer software empowers you to move from complex data to confident decisions—fast and accessible through the SCIEX OS software dashboard.
With intuitive, interactive visualizations, you can explore your biologics data in ways that are both powerful and easy to understand.
Wide variety of workflows
Biologics Explorer software supports the most important LC-MS characterization assays right out of the box, leveraging industry best practices and an intuitive nodal workflow structure that is easy to optimize for your specific analytical needs. Now enhanced with data integrity and traceability tools for select workflows, including user authentication, audit trails, and enhanced reporting to help regulated biopharma laboratories streamline characterization while supporting compliance-focused processes. Workflow support is expanding and currently include: intact protein and peptide mapping workflows
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Intact protein and subunit analysis
Cut through the noise in real time to visualize what matters and interact with the answer directly. Biologics Explorer software provides one simple solution that delivers visual and written data for the characterization of intact protein therapeutics.
Heat maps and a 3D display provide a multi-dimensional view of data files to facilitate quick assessment of data quality and impurity level at the intact level.
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Middle-down mAb fragment analysis
Perform comprehensive analysis of protein subunits, with templates optimized for biotherapeutic characterization. Achieve consistent high-sequence coverage, enable rapid method development and confident PTM localization with intuitive visual tools. Make decisions on candidate developability or product quality sooner.
Streamline method development and gain critical information quickly with simple visual tools for comparative analysis.
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Peptide mapping
Maximize efficiency with pipeline specific workflow templates optimized based on needs:
- Quick and efficient peptide mapping for quality checks
- In-depth peptide mapping
- Detect unexpected modifications
- N-/O-glycan site specific mapping
- Isomer differentiation
Visualize sequence coverage and modifications in a single interactive viewing pane.
- Sequence coverage map with color coding to indicate modification type
- Identified peptides shown in table format
- See MS/MS information by selecting desired peptide
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Disulfide bond and PTM determination
Enable comprehensive identification and spectra annotation of complex peptides with disulfide linkages.
Disulfide bond mapping using CID and EAD.
Visualize CID (A) and EAD (B) provide complementary results for a disulfide-linked peptide from the HC of T-DXd.
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Multi-attribute methodology (MAM)
Reduce overall analytical testing burden with ready-to-use workflow templates. Enable confident peptide mapping results and visualization tools, with the ability to export product quality attribute (PQA) lists to compliance-ready SCIEX OS software for quantification and monitoring.
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Intabio ZT system
Access multidimensional data from one integrated icIEF-UV/MS workflow. Within one layout simultaneously view UV electropherogram, results summary, MS data, deconvoluted ion map results and raw MS data to generate a single report for comprehensive overview of charge variants with peak identification.
Biologics Explorer software relates all the information for proteoform identification on one screen.
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Intact oligonucleotide analysis
A powerful all-in-one software solution that simplifies and accelerates analysis across a wide range of oligonucleotide workflows.
Ready-to-use templates for efficient analysis of oligonucleotides – from small ASOs and siRNAs to large molecules like sgRNAs.
Assess mRNA related CQAs such as Poly-A tail heterogeneity and 5’ capping efficiency
Flexibility to add custom nucleotide definitions
Seamlessly correlate UV and MS data for deeper insights and quantification
Confirm the mass as well as abundance of the expected molecule as well as unexpected modifications with confidence.
Easily assess and visualize poly-A tail heterogeneity
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Oligonucleotide sequencing
Easily build confidence in your results by leveraging MS/MS data
- Confirm the sequence of the intended product
- Automated sequence prediction enables easy detect of impurities or degradation products
- Seamlessly correlate UV and MS data for deeper insights and quantification
The -9 charge state of Nusinersen is shown along with the presence of the desulfurized degradation product. The inset shows the MS/MS data along with a representation of the 5’ and 3’ terminal ions identified as well as the location of the desulfurization.
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09:
Oligonucleotide mapping
Perform comprehensive analysis of larger oligonucleotides by digestion with nucleases followed by LC-MS/MS sequence confirmation and mapping.
Visualize sequence coverage and modifications in a single interactive viewing pane.
- Sequence coverage map with color coding to indicate modification type
- Identified oligos following digestion shown in table format
- TOF-MS spectrum corresponding to the selected oligonucleotide, zoomed into -6 charge state
- MS/MS data for the selected Oligonucleotide
Visualizations provide insight
- Next generation biologics are becoming more complex with more potential post-translational modifications and protein forms. This produces a vast amount of digital information from mass spec characterization.
- With the use of intuitive visualizations, Biologics Explorer software gets you from sample to insight - fast! The software provides the ability to immediately see patterns and features even in raw data, ensuring you don't miss identifying anything important.
Built for EAD
- Electron activated dissociation (EAD) in the ZenoTOF 7600 system breaks new ground in depth of coverage for peptide mapping and PTM analysis of biopharmaceuticals. EAD produces incredibly rich MS/MS spectra.
- Biologics Explorer software is critical for transforming those rich spectra into incredibly informative results. The data processing engine is optimized to extract the maximum amount of information from every CID and EAD spectrum.
Transparency from start to report
- Unlike Biologics Explorer, biologics characterization in some applications can leave you wondering how exactly the result was reached. The data can go in, and an answer can come out, without any clarity around how it happened.
- Biologics Explorer software is all about transparency. The workflow-based setup allows you to see all the steps of what is happening with optimization at each node to get the best out of your data.
Data integrity and traceability
- Purpose-built for regulated biopharma workflows, with user authentication and role-based access control that keep biologics characterization in a secure framework where only authorized users can act.
- A comprehensive audit trail and consistent documentation capture every system activity, from data processing to result review, reducing manual tracking and upholding data integrity for regulatory review.
- Formalized report approvals and sign-off let teams work efficiently with full confidence in their data, bringing greater traceability and control.
- SCIEX compliance products deliver a complete system—LC, MS, software, and LC-MS—that minimizes regulatory risk at a fixed, predictable cost while reducing the need for in-house compliance expertise. Every deliverable follows standard good documentation practices, arrives audit-ready, and removes the worry of regulatory compliance, building greater confidence in data quality.
Powered by Genedata Expressionist®
- Biologics Explorer software is built upon an industry-leading platform for biopharmaceutical mass spectrometry. Leveraging the expert knowledge and proven capabilities of Genedata Expressionist®.
Biologics Explorer software is compatible with these featured systems below and across all SCIEX high resolution mass spectrometers:
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
A purpose-built QTOF system, designed specifically to accelerate everyday biologics characterization.
Eliminate the guess work and monitor biologics at the intact-protein level, gaining insights into charge variant-associated quality attributes.