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- TripleTOF 6600 System
The Power of Precision
Take on new analytical challenges and extend your research capability with the TripleTOF® 6600 quadrupole time-of-flight (QTOF) mass analyzer.
Built with versatility in mind, TripleTOF technology unleashes sensitivity, speed and productivity in a single multifaceted platform to help you dig deeper into complex samples. Ultra-fast acquisition rates allow you to collect high-resolution MS/MS data on every detectable analyte in your sample, giving you the potential you need to advance your research.
Power your workflows with high-resolution accurate mass LC-MS
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Key features | |
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Enhanced selectivity with differential ion mobility |
Get more out of every sample with an additional dimension of separation with SelexION® Differential Ion Mobility Technology. |
Robust spray with the renowned Turbo V™ Source |
Efficient ion production while limiting contamination for maximized robustness, reliability and uptime. |
Comprehensive coverage with data-Independent SWATH® Acquisition |
Variable window capabilities allow for a large number of Q1 isolation windows at user controlled widths, up to 200 per cycle to achieve better specificity, even in complex samples.
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Maximize flexibility with front end separations |
Compatible with advanced front-end separation strategies including high-flow, microflow and nanoflow, and capillary electrophoresis spray ionization (CESI). |
Taking mass spec analysis to the edge
With more ions produced, better ion focusing, improved ion reflection and maximized detection, you will experience the performance edge with the TripleTOF 6600 System. Optimized instrument control electronics in conjunction with patented LINAC collision cell technology delivers ultra-fast acquisition rates of up to 100 MS/MS per cycle for IDA mode and 200 MS/MS per cycle for SWATH® data-independent acquisition, without compromising resolution.
The new design of the legendary Turbo V source increases ion production by using enhanced gas flow dynamics and optimized heater configuration to improve reliability, reproducibility, and robustness at higher flow rates.
Designed for robustness, the QJet Ion guide provides large capture radius for efficient transfer of ions from source to quadrupole optics.
High drive frequency collision cell provides better ion transmission, higher duty cycle, and improved resolution by focusing ions prior to entering TOF.
Time-of-flight analyzer uses a 2-stage mirror and 15 kV acceleration to improve resolution and efficiency. Get the speed and sensitivity required for triple quadrupole like quantitation, but with high resolution and mass accuracy for qualitative applications.
4-channel MCP detector with ADC processing technology provide more than 5-orders of linear dynamic range while improving robustness and lifetime at high ion currents.
Key features | |
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Mass range TOF | 5 – 40,000 m/z |
Mass selection range Q1 | 5 – 2250 m/z |
TOF-MS mass resolution and acquisition speed | ≥35,000 (FWHM) at 956 m/z, using 10 ms accumulation time |
TOF-MS/MS mass resolution and acquisition speed | ≥30,000 (FWHM) at 813 m/z, and ≥25,000 (FWHM) at 195 m/z, using 10 ms accumulation time |
Detector type | 4-channel MCP detector with ADC signal processing for extended dynamic range |
Flexible data acquisition workflows | TOF-MS Information dependent acquisition (IDA) MS/MS Data independent SWATH® Acquisition with fixed or variable Q1 isolation windows Targeted MRMHR workflow |
Ionization sources | IonDrive™ Turbo V, DuoSpray™ Source, each with TurboIonSpray® or atmospheric-pressure chemical ionization (APCI) probes available; NanoSpray® III Source, Digital PicoView NanoSource |
Orthogonal front end separation compatibility | Compatible with advanced front-end separation strategies including high-flow, microflow and nanoflow chromatography, capillary electrophoresis spray ionization (CESI), or using SelexION® Differential Ion Mobility |
Variable window SWATH® Acquisition | Data-independent SWATH® Acquisition with variable window capabilities, allows for a large number of Q1 isolation windows at user-controlled widths, up to 200 per cycle to achieve better specificity, even in complex samples. Read More |
Data file portability | Condensed data file sizes simplify and streamline data storage and portability for sharing with colleagues, without losses in data quality, completeness or security |
Take a tour of the key components of the 6600 that will power your workflows.
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Analyze your complex samples faster without compromising between speed, resolution and sensitivity. Identify and quantify your sample components more comprehensively across a broad dynamic range of concentrations with the high-resolution MS/MS, at ultra-fast acquisition speeds.
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Process your SWATH data faster, and integrate multi-omics data seamlessly and securely in one place
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Qualitative review of LC-MS and LC-MS/MS data with advanced peak ID and profiling software
Whether you need the highest sensitivity of CESI or NanoLC for biomarker discovery experiments or higher flow rates for throughput and robustness, the TripleTOF System offers complete flexibility so it can be configured to meet your specific workflow needs. Coupled with industry-leading software packages for fast data to results, the TripleTOF is the one system that is versatile enough to answer all your questions.
Achieve enhanced separation with integrated capillary electrophoresis (CESI)
The most flexible low flow LC system, offering high reproducibility across a wide flow rate range
Optimized MicroLC System for high-throughput workflows and limited sample volumes
Analytical flow LC with superior expandability, robustness and carryover performance
Fast, reproducible and easy-to-use ion mobility device for heightened selectivity
Easily switch to the most appropriate flow rate for your experiment without breaking vacuum