For research use only. Not for use in diagnostic procedures.
The TripleTOF 6600 System extends the power and features of TripleTOF technology, delivering high performance and reproducibility that can detect virtually every peptide in every run when executing SWATH® Acquisition 2.0. The TripleTOF 6600 System offers:
The TripleTOF 6600 System maximizes productivity with its real-time management of MS/MS acquisition time, based on the intensity of selected precursors.
Take on new analytical challenges and extend your research capability with the TripleTOF® 6600 Quadrupole Time-Of-Flight (QTOF) mass analyzer.
Built with versatility in mind, the TripleTOF technology unleashes sensitivity, speed, and productivity in a single multifaceted platform to help you dig deeper into complex samples. Ultra-fast acquisition rates allow you to collect high-resolution MS/MS data on every detectable analyte in your sample, giving you the potential you need to advance your research.
|Mass Range TOF||5 – 40,000 m/z|
|Mass Selection Range Q1||5 – 2250 m/z|
|TOF-MS Mass Resolution and Acquisition Speed||≥35,000 (FWHM) at 956 m/z, using 10 ms accumulation time|
|TOF-MS/MS Mass Resolution and Acquisition Speed||≥30,000 (FWHM) at 813 m/z, and ≥25,000 (FWHM) at 195 m/z, using 10 ms accumulation time|
|Detector Type||4-channel MCP detector with ADC signal processing for extended dynamic range|
|Flexible Data Acquisition Workflows||
|Ionization Sources||IonDrive™ Turbo V or DuoSpray™ source, each with TurboIonSpray® or Atmospheric-pressure chemical ionization (APCI) probes available; NanoSpray® III source, Digital PicoView NanoSource|
|Orthogonal Front End Separation Compatibility||Compatible with advanced front-end separation strategies including high-flow, microflow and nanoflow chromatography, capillary electrophoresis spray ionization (CESI), or using SelexION® differential ion mobility|
|Variable Window SWATH® Acquisition||Data-Independent SWATH® Acquisition with variable window capabilities, allows for a large number of Q1 isolation windows at user controlled widths, up to 200 per cycle to achieve better specificity, even in complex samples. Read More >|
|Data File Portability||Condensed data file sizes simplify and streamline data storage and portability for sharing with colleagues, without losses in data quality, completeness or security|
With more ions produced, better ion focusing, improved ion reflection and maximized detection, you will experience the performance edge with the TripleTOF 6600 system. Optimized instrument control electronics in conjunction with patented LINAC collision cell technology delivers ultra-fast acquisition rates of up to 100 MS/MS per cycle for IDA mode and 200 MS/MS per cycle for SWATH® data-independent acquisition, without compromising resolution.
The new design of the legendary Turbo V source increases ion production by using enhanced gas flow dynamics and optimized heater configuration to improve reliability, reproducibility, and robustness at higher flow rates.
Designed for robustness, the QJet Ion guide provides large capture radius for efficient transfer of ions from source to quadrupole optics.
High drive frequency collision cell provides better ion transmission, higher duty cycle, and improved resolution by focusing ions prior to entering TOF.
Time-of-flight analyzer uses a 2-stage mirror and 15 kV acceleration to improve resolution and efficiency. Get the speed and sensitivity required for triple quadrupole like quantitation, but with high resolution and mass accuracy for qualitative applications.
4-channel MCP detector with ADC processing technology provide more than 5-orders of linear dynamic range while improving robustness and lifetime at high ion currents.
Analyze your complex samples faster without compromising between speed, resolution and sensitivity. Identify and quantify your sample components more comprehensively across a broad dynamic range of concentrations with the high-resolution MS/MS, at ultra-fast acquisition speeds.
Balance throughput and sensitivity for large scale proteomics studies with Microflow SWATH
Analyze multi-omic datasets, boost processing power, and visualize biological results with OneOmics™ cloud based tools
Obtain high-quality quantitation with MRMHR workflow, for targeted analysis of proteins, lipids or small molecule metabolites
Broadly profile large numbers of lipids with the unique Infusion MS/MSALL workflow
From qualitative characterization experiments to high quality quantitation, this system gives you the power, sensitivity and flexibility to support and advance your therapeutic discovery and development pipeline.
Be confident you’re not missing low level or toxic metabolites or catabolites in your sample
Identify low level host cell proteins you didn’t know existed using data-independent SWATH® Acquisition
Sensitivity and large dynamic range enables sequence variant detection during biotherapeutic development
Give your lab the flexibility to take on new challenges and projects by choosing a platform that offers maximum versatility. Quickly get up and running with new workflows by employing a familiar system with the widest breadth of applications available.
Couple the most advanced hardware platform with industry leading software processing, and you will accelerate discoveries across multiple applications, from proteomics, metabolomics and lipidomics to food/environmental screening and biologics characterization.
Process your SWATH data faster, and integrate multi-omics data seamlessly and securely in one place
Enhance your proteomic studies with rigorous enhanced database searching and confident protein assignments
Easily find, identify and interpret lipid species from MS data of complex samples
Interpret your metabolism and biologic catabolism data faster with high-throughput processing
Whether you need the highest sensitivity of CESI or NanoLC for biomarker discovery experiments, or higher flow rates for throughput and robustness, the TripleTOF system offers complete flexibility so it can be configured to meet your specific workflow needs. Coupled with industry leading software packages for fast data to results, the TripleTOF is the one system that is versatile enough to answer all your questions.
Achieve enhanced separation with integrated capillary electrophoresis (CESI)
The most flexible low flow LC system, offering high reproducibility across a wide flow rate range
Optimized MicroLC system for high-throughput workflows and limited sample volumes
Analytical flow LC with superior expandability, robustness and carryover performance
For research use only. Not for use in diagnostic procedures.
Quantify thousands of proteins across large sample sets with greater accuracy and reproducibility than ever before. As your lab needs shift from small discovery experiments to quantitative work on larger sample sets, your need for comprehensive quantitation will grow. Now there is a proteomics platform with the features and performance that deliver real biological insights to power your research in the years ahead.
Empower your biological research through comprehensive quantitation
SWATH® 2.0 Acquisition delivers the combination of low variability and comprehensive coverage with coefficients of variation previously achievable only by targeted techniques - increasing capacity up to 30X vs. conventional targeted proteomics.
Attain better data with greater precision, accuracy and completeness
Providing an additional full order of linear dynamic range in MS and MS/MS, the TripleTOF 6600 System lets you dig deeper to quanitify low-abundant analytes from high resolution accurate mass data.
Achieve faster time-to-results
Experience up to 10X faster sample-to-answers than conventional targeted proteomic methods with higher multiplexing.
|Intact and reduced therapeutic monoclonal antibodies||01/25/2018|
|Studying Quality Attributes of Adalimumab by Mass Spectrometry||01/10/2018|
|Analysis of Intact Monoclonal Antibodies Using an M3 MicroLC with the TripleTOF 6600||01/05/2018|
|Isotope Ratio Outlier Analysis (IROA) and Variable Window SWATH® Acquisition||01/02/2018|
|Multi-Omics Analysis of Human Embryonic Stem Cell Neural Differentiation||12/22/2017|
|SWATH Acquisition Improves Metabolite Coverage over Traditional Data Dependent Techniques for Untargeted Metabolomics||12/22/2017|
|Automated HIgh Throughput Trypsin Digests for HIghly Reproducible Peptide Map Analysis||12/20/2017|
|Immunoaffinity-High Resolution Accurate Mass Assay for Pre-Clinical Quantification of Trastuzumab in Rat Plasma||12/17/2017|
|Application of Data Independent Acquisition for Top-Down Characterization of IgG Light Chain||12/15/2017|
|Ultra-sensitive Host Cell Protein Dection using CESI-MS with SWATH Acquisition||12/10/2017|
|User Guide: SelexION and SelexION+ Technology Troubleshooting||09/30/2017|
|Advanced Biotransform Solution: Sensitive Microflow Analysis of Peptide Catabolism||09/15/2017|
|CouldConnect Auto Uploader||09/12/2017|
|TripleTOF 6600 3D Animation||08/10/2017|
|TripleTOF 6600 Flyer||08/10/2017|
|Novel Labeled Metabolomics Workflow applying Isotope Ratio Outlier Analysis (IROA) and SWATH Acquisition for Unambiguous Compound Identification||07/06/2017|
|SCIEX Quantitation and Metabolism Solutions Brochure||05/26/2017|
|Die Bedeutung der LC-HRMS bei der Sicherung der Trinkwasserqualität||05/24/2017|
|MetabolitePilot Software 2.0||05/04/2017|
|Advanced Biotransform Solution Guide||03/28/2017|
|Metabolite Identification of Payload Species of Antibody Drug Conjugates with Noncleavable Linkers using MetabolitePilot 2.0 Software and TripleTOF 6600 System||03/16/2017|
|Therapeutic Peptide Catabolite Identification using MetabolitePilot 2.0 Software and the TripleTOF 6600 System||03/16/2017|
|CESI 8000 Plus paired with the TripleTOF 6600 for the analysis of Protein Therapeutics||02/28/2017|
|Increasing Depth of Coverage in Data Independent Acquisition with Higher Sample Loads and Smaller Q1 Windows||01/10/2017|
|Accelerating Protein ID for Deep Proteome Profiling||01/01/2017|
|MarkerView Software 1.3 New Features||12/15/2016|
|M3 MicroLC for TripleTOF-Test and Data Log||12/10/2016|
|M3 MicroLC-TE for TripleTOF-Test and Data Log||12/10/2016|
|Assessing Impact of Extended Gradient Lengths for Microflow SWATH Acquisition||09/15/2016|
|Why Compromise? The Benefit of High-Resolution Quantitative Analysis||09/15/2016|
|Solutions for Biotherapeutic Characterization||09/01/2016|
|NanoLC Systems for TripleTOF systems Test and Data Log||09/01/2016|
|Streamlining Discovery Microsomal Clearance and Metabolite ID Analysis using SCIEX TripleTOF 6600||08/01/2016|
|PCT-SWATH for Protein Quantitation-Tissue to Peptids in 4 Hours||07/01/2016|
|Accelerating Data Independent Acquisition with Microflow Chromatography||06/06/2016|
|Improving DIA Quantitation with microLC Using a Longer Gradient||06/06/2016|
|Host Cell Protein Analysis by Microflow-LC High Resolution SWATH-MS of Vaccine Samples Under Development||06/06/2016|
|Comprehensive Relative Quantification of the Cytochromes P450 by Micro-LC and SWATH Acquisition||06/06/2016|
|Drug Metabolism-Chging landscape||05/15/2016|
|UHPLC-ESI-QTOF-MS/MS based Lipidomics by Data-independent Acquisition||05/11/2016|
|Studying Kinetics of Chromatin Assembly with SWATH MS||05/11/2016|
|The Lipidyzer- a new platform for quantitative Lipidomics||05/11/2016|
|CESI-MS a technique for the characterization and analysis of both intact and digested biopharmaceuticals||05/11/2016|
|industrializing omics-SCIEX Life Science Research towards Precision Medicine||05/01/2016|
|Innovation for Biotherapeutic Comparability with BioPharmaView Software Solution Guide||05/01/2016|
|Simultaneous analysis of 12 food allergens in baked and raw food products using the LC-MS/MS QTRAP 4500 system||05/01/2016|
|BioPharmaView Software Overview Video||05/01/2016|
|Industrializing Quantitative Proteomics Using Microflow LC and SWATH Acquisition||04/27/2016|
|User Guide: TripleTOF Systems Electromagnetic Environment Information||04/20/2016|
|TripleTOF 6600 Declaration of Conformance||04/20/2016|
|Microflow SWATH Acquisition for Industrialized Quantitative Proteomics||04/01/2016|
|Understanding Complex Lipid Metabolism through Quantitative Lipidomics||03/15/2016|
|Host cell protein detection using CESI-MS with SWATH||02/09/2016|
|Unification of Charge Heterogeneity, Purity, and Molecular Weight Analyses of mAbs into a Single Analysis||12/05/2015|
|Improved Data Quality Using Variable Q1 Window Widths in SWATH Acquisition||11/16/2015|
|Eksigent MicroLC 200/200 Plus Systems||10/05/2015|
|User Guide: Ion Source Tests, Specifications, and Data Log||09/16/2015|
|High-Throughput SWATH-MS for Biopsy-Level Samples||09/15/2015|
|User Guide: IonDrive Turbo V Ion Source Operator Guide (IT)||08/31/2015|
|User Guide: IonDrive Turbo V Ion Source Operator Guide (DE)||08/31/2015|
|User Guide: IonDrive Turbo V Ion Source Operator Guide||08/31/2015|
|User Guide: IonDrive Turbo V Ion Source Operator Guide (FR)||08/31/2015|
|User Guide: Turbo V Ion Source Operator Guide (ES)||08/31/2015|
|User Guide: Turbo V Ion Source Operator Guide (IT)||08/31/2015|
|User Guide: Turbo V Ion Source Operator Guide (DE)||08/31/2015|
|User Guide: Turbo V Ion Source Operator Guide (FR)||08/31/2015|
|User Guide: NanoSpray Ion Source Operator Guide||08/31/2015|
|User Guide: IonDrive Turbo V Ion Source Operator Guide (ES)||08/31/2015|
|User Guide: Turbo V Ion Source Operator Guide||08/31/2015|
|Next-Generation Proteomics Platform||08/01/2015|
|Ultra-sensitive Host Cell Protein Detection using CESI-MS with SWATH Acquisition||06/01/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide||05/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide (DE)||05/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide (IT)||05/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide (FR)||05/31/2015|
|SelexION Technology for TripleTOF Systems User Guide (ES)||05/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide||03/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide (DE)||03/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide (FR)||03/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide (IT)||03/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide (ES)||03/31/2015|
|Spectral Libraries for Food Analysis - Antibiotics||03/05/2015|
|Spectral Libraries for Food Analysis - Pesticides||03/05/2015|
|User Guide: SCIEX TripleTOF 6600 System Site Planning Guide (DE)||10/01/2014|
|User Guide: SCIEX TripleTOF 6600 System Site Planning Guide (IT)||10/01/2014|
|User Guide: SCIEX TripleTOF 6600 System Site Planning Guide (FR)||10/01/2014|
|User Guide: SCIEX TripleTOF 6600 System Site Planning Guide||09/01/2014|
|User Guide: TripleTOF 6600 System User Guide||07/01/2014|
|User Guide: TripleTOF 6600 System User Guide (FR)||07/01/2014|
|User Guide: TripleTOF 6600 System User Guide (IT)||07/01/2014|
|User Guide: TripleTOF 6600 System User Guide (DE)||07/01/2014|
|User Guide: Turbo V Ion Source Operator Guide (PL)||07/01/2014|
|User Guide: Turbo V Ion Source Operator Guide (PT)||07/01/2014|
|User Guide: Turbo V Ion Source Operator Guide (RU)||07/01/2014|
|User Guide: Turbo V Ion Source Operator Guide (ZH)||07/01/2014|
|User Guide: Turbo V Ion Source Operator Guide (JA)||07/01/2014|
|Announcing SWATH® Acquisition 2.0||06/12/2014|
|Innovations in Biologics||06/01/2014|
|Next-Generation Proteomics Platform||06/01/2014|
|User Guide: TripleTOF 6600 System Qualified Maintenance Person Guide||06/01/2014|
|User Guide: TripleTOF 6600 System Qualified Maintenance Person Guide (FR)||06/01/2014|
|User Guide: TripleTOF 6600 System Qualified Maintenance Person Guide (IT)||06/01/2014|
|User Guide: Calibrant Delivery System Operator Guide||06/01/2014|
|User Guide: Calibrant Delivery System Operator Guide (DE)||06/01/2014|
|User Guide: Calibrant Delivery System Operator Guide (FR)||06/01/2014|
|User Guide: Calibrant Delivery System Operator Guide (IT)||06/01/2014|
|User Guide: DuoSpray Ion Source for TripleTOF Systems Operator Guide||06/01/2014|
|User Guide: DuoSpray Ion Source for TripleTOF Systems Operator Guide (DE)||06/01/2014|
|User Guide: DuoSpray Ion Source for TripleTOF Systems Operator Guide (FR)||06/01/2014|
|User Guide: DuoSpray Ion Source for TripleTOF Systems Operator Guide (IT)||06/01/2014|
|User Guide: NanoSpray Ion Source Operator Guide (IT)||06/01/2014|
|User Guide: NanoSpray Ion Source Operator Guide (DE)||06/01/2014|
|User Guide: NanoSpray Ion Source Operator Guide (FR)||06/01/2014|
|TripleTOF HRMS System Features for Screening Unknown Contaminant in Foods||03/04/2014|
|Instrument Front-End Cleaning Procedure Manual||10/01/2013|
|Rapid and Unbiased Quantitation of Host Cell Protein Contaminants in Biologics by MSMS of All Using a TripleTOF Mass Spectrometer||09/24/2013|
|Advancing your Forensic Toxicology Analyses; Adopting the Latest in Mass Spectrometry Innovations||07/01/2013|
|Increasing the Multiplexing of High Resolution Targeted Peptide Quantification Assays||01/01/2012|
|ImpurityPilot Software 1.0 Beta||08/01/2011|
|User Guide: TripleTOF 6600 System Qualified Maintenance Person Guide (DE)|
|User Guide: NanoSpray Head and Emitter Tip Assembly Quick Start Guide|
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