Take on new analytical challenges and extend your research capability with the TripleTOF® 6600 quadrupole time-of-flight (QTOF) mass analyzer.
Built with versatility in mind, TripleTOF technology unleashes sensitivity, speed and productivity in a single multifaceted platform to help you dig deeper into complex samples. Ultra-fast acquisition rates allow you to collect high-resolution MS/MS data on every detectable analyte in your sample, giving you the potential you need to advance your research.
Power your workflows with high-resolution accurate mass LC-MS
Fast acquisition speed with no compromise in data resolution to identify more compounds in your sample
More complete data-with high-resolution MS/MS data on every detectable analyte
Advanced workflow capabilities – with high-performance sensitivity
Enhanced quantitation- with extended linear dynamic range
Enhanced selectivity with differential ion mobility
Get more out of every sample with an additional dimension of separation with SelexION® Differential Ion Mobility Technology.
Robust spray with the renowned Turbo V™ Source
Efficient ion production while limiting contamination for maximized robustness, reliability and uptime.
Comprehensive coverage with data-Independent SWATH® Acquisition
Variable window capabilities allow for a large number of Q1 isolation windows at user controlled widths, up to 200 per cycle to achieve better specificity, even in complex samples.
Maximize flexibility with front end separations
Compatible with advanced front-end separation strategies including high-flow, microflow and nanoflow, and capillary electrophoresis spray ionization (CESI).
High resolution accurate mass spec technology
Taking mass spec analysis to the edge
With more ions produced, better ion focusing, improved ion reflection and maximized detection, you will experience the performance edge with the TripleTOF 6600 System. Optimized instrument control electronics in conjunction with patented LINAC collision cell technology delivers ultra-fast acquisition rates of up to 100 MS/MS per cycle for IDA mode and 200 MS/MS per cycle for SWATH® data-independent acquisition, without compromising resolution.
IonDrive™ Turbo V Source
The new design of the legendary Turbo V source increases ion production by using enhanced gas flow dynamics and optimized heater configuration to improve reliability, reproducibility, and robustness at higher flow rates.
QJet® Ion Guide
Designed for robustness, the QJet Ion guide provides large capture radius for efficient transfer of ions from source to quadrupole optics.
LINAC® Collision Cell
High drive frequency collision cell provides better ion transmission, higher duty cycle, and improved resolution by focusing ions prior to entering TOF.
Accelerator TOF™ Analyzer
Time-of-flight analyzer uses a 2-stage mirror and 15 kV acceleration to improve resolution and efficiency. Get the speed and sensitivity required for triple quadrupole like quantitation, but with high resolution and mass accuracy for qualitative applications.
4-channel MCP detector with ADC processing technology provide more than 5-orders of linear dynamic range while improving robustness and lifetime at high ion currents.
≥35,000 (FWHM) at 956 m/z, using 10 ms accumulation time
TOF-MS/MS mass resolution and acquisition speed
≥30,000 (FWHM) at 813 m/z, and ≥25,000 (FWHM) at 195 m/z, using 10 ms accumulation time
4-channel MCP detector with ADC signal processing for extended dynamic range
Flexible data acquisition workflows
Information dependent acquisition (IDA) MS/MS
Data independent SWATH® Acquisition with fixed or variable Q1 isolation windows
Targeted MRMHR workflow
IonDrive™ Turbo V, DuoSpray™ Source, each with TurboIonSpray® or atmospheric-pressure chemical ionization (APCI) probes available; NanoSpray® III Source, Digital PicoView NanoSource
Orthogonal front end separation compatibility
Compatible with advanced front-end separation strategies including high-flow, microflow and nanoflow chromatography, capillary electrophoresis spray ionization (CESI), or using SelexION® Differential Ion Mobility
Variable window SWATH® Acquisition
Data-independent SWATH® Acquisition with variable window capabilities, allows for a large number of Q1 isolation windows at user-controlled widths, up to 200 per cycle to achieve better specificity, even in complex samples. Read More
Data file portability
Condensed data file sizes simplify and streamline data storage and portability for sharing with colleagues, without losses in data quality, completeness or security
Take a tour of the key components of the 6600 that will power your workflows.
Explore the Unique TripleTOF System Technology
Workflows powered by the TripleTOF 6600 System
Introducing the multi-omics powerhouse
Analyze your complex samples faster without compromising between speed, resolution and sensitivity. Identify and quantify your sample components more comprehensively across a broad dynamic range of concentrations with the high-resolution MS/MS, at ultra-fast acquisition speeds.
Balance throughput and sensitivity for large scale proteomics studies with Microflow SWATH.
The optimal choice for comprehensive pharma/biopharma analysis
From qualitative characterization experiments to high quality quantitation, this system gives you the power, sensitivity and flexibility to support and advance your therapeutic discovery and development pipeline.
Comprehensive drug metabolism
Be confident you’re not missing low level or toxic metabolites or catabolites in your sample
Take on new challenges and projects by choosing a platform that offers maximum versatility. Quickly get up and running with new workflows by employing a familiar system with the widest breadth of applications available.
Comprehensive and proven solutions to obtain and analyze large amounts of data accurately.
Couple the most advanced hardware platform with industry leading software processing, and you will accelerate discoveries across multiple applications, from proteomics, metabolomics and lipidomics to food/environmental screening and biologics characterization.
Process your SWATH data faster, and integrate multi-omics data seamlessly and securely in one place
Flexible configurations to change the way you work
Whether you need the highest sensitivity of CESI or NanoLC for biomarker discovery experiments or higher flow rates for throughput and robustness, the TripleTOF System offers complete flexibility so it can be configured to meet your specific workflow needs. Coupled with industry-leading software packages for fast data to results, the TripleTOF is the one system that is versatile enough to answer all your questions.
Capillary electrophoresis ESI
Achieve enhanced separation with integrated capillary electrophoresis (CESI)