ZenoTOF 7600
mass spectrometer

Be Extraordinary

A powerful leap in proprietary innovation, this high-resolution accurate mass system combines the power of Zeno trap pulsing with EAD fragmentation technology (electron activated dissociation) to uncover structural information, previously inaccessible, and drive the limits of quantification achievable with accurate mass.

ZenoTOF 7600 system

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Welcome to the Zeno revolution.

Driven by the power of the Zeno trap coupled with EAD fragmentation technology, this fragment-centric revolution unlocks sensitivity gains allowing you to uncover new information for certainty in your results to make better-informed decisions, faster.

Detect up to 20x more ions in every experiment and access a spectrum of tuneable fragmentation techniques to unlock new perspectives for every molecule, in every experiment.

Zeno opens the door to a ‘fragment centric revolution’
Maarten Dhaenens Ghent University, Belgium

The Zeno revolution is now...

Zeno trap and EAD. A powerful combination of unparalleled MS/MS sensitivity and a step-change in fragmentation technology. Together they provide the ability to acquire key MS/MS features needed to:

  • Characterize large molecules including post-translational modifications
  • Elucidate positional isomers on small molecules and lipids
  • Identify and quantify proteins and peptides at unparalleled speed
Overcome QTOF MS/MS duty cycle deficiencies

Overcome QTOF MS/MS duty cycle deficiencies

  • >90% ions injected into the TOF
  • Sensitivity gains of up to 5-20X with Zeno trap pulsing
  • Identify and quantify low abundance species
Tunable fragmentation of all molecule types

Tunable fragmentation of all molecule types

Utilize controlled electron activated dissociation (EAD)
MS/MS scan rates of up to 133Hz

MS/MS scan rates of up to 133Hz

Improved DDA and High resolution MRMHR

EAD

Electron activated dissociation (EAD)

EAD allows for a range of free electron based fragmentation mechanisms within one device. The ability to tune electron kinetic energy within an EAD experiment extend the utility of the approach to all molecules type from singly charged small molecules to large multiply charged proteins.

EAD 5ev EAD 7ev EAD 9ev

Biomolecule analysis

Protein based therapeutics come with a rich assortment of varying structures. Those modifications exist in complex heterogeneous mixtures.

CID has been used extensively to determine the structure of biomolecules but full characterization can be difficult without further sample processing e.g. digestions.

Low energy EAD fragmentation enables characterization of intact biomolecules via top down approaches allowing researchers to rapidly identify and confirm key structural attributes.

Technical note: Qualitative flexibility combined with quantitative power Open link

Post-translational modifications

When tuned to higher kinetic energies, EAD has the capability to fragment post-translationally modified peptides such as phosphopeptides and glycopeptides whilst retaining critical MS/MS information for both identification and localisation of PTMs. Unlike other electron-based fragmentation techniques, this can be achieved in conjunction with fast scan speeds and in a reproducible, consistent manner.

The EAD cell brings fresh insight and completes the picture for biomolecule characterization. EAD, fragmentation of large multiply-charged produces those differential C & Z ions to garner those critical insights.

Technical note: A new electron activated dissociation (EAD) approach for comprehensive glycopeptide analysis of therapeutic proteins Open link Technical note: Tuneable electron activated dissociation (EAD) MS/MS to preserve particularly labile post-translational modifications Open link

Small molecules

CID fragmentation of small molecules can produce limited and/ or non-specific MS/MS information, giving rise to challenges in identification or lack of specificity in the development of quantitative assays.

High-energy EAD fragmentation can produce highly specific MS/MS information on small molecules such as endogenous metabolites or the products of drug metabolism. This enables confident, unambiguous identification and highly specific MS/MS-based quantification.

Technical note: Complete structural elucidation of lipids in a single experiment using Electron-Activated Dissociation (EAD) Open link

Zeno trap

The next era of sensitivity for accurate mass

Ions are accumulated in the Zeno trap before being pulsed rapidly into the TOF, meaning we can detect up to 20x more ions.

Consequently, each TOF experiment contains more useful MS/MS information, particularly on lower abundance species that were previously undetectable, introducing our customers to a new sensitivity revolution.

Without Zeno trap pulsing

With Zeno trap pulsing

Use this slider to see the impact of Zeno trap pulsing on this interactive graphic.

Rare quantifiable data becomes your everyday

Zeno DDA EAD/ CID

Zeno DDA EAD/ CID

Fresh perspective and certainty.

SWATH Acquisition

SWATH acquisition

New depth of rare data.

Zeno MRMHR

Zeno MRMHR

High sensitivity and specificity.

A new data landscape enabled by Zeno

Zeno DDA (CID/EAD)

EAD technology allows you to fine tune the electron energy, accessing multiple fragmentation mechanisms that can be applied to large molecules, peptides, lipids and small molecules.

  • 40% more proteins identified using Zeno MS/MS
  • Characterization of lipids in a single experiment
  • Comprehensive coverage and localized glycans in a single run

SWATH acquisition

The eternal dataset. SWATH acquisition delivers comprehensive data-independent acquisition that can be used to quantify every observable species in a sample.

  • SWATH acquisition for higher throughput proteomics

Zeno MRMHR

Zeno trap pulsing on demand gives the ability to detect lower abundance ions with those in abundance at the same time driving the limits of quantification achievable with accurate mass.

  • Zeno MRMHR unlocks new levels of sensitivity

A new data landscape enabled by Zeno

Explore the ZenoTOF 7600

H: 112cm W: 67cm L: 142cm
The system exterior
ION Sources
System - Exterior USP (ION)

Ion Sources

Advanced source designs that limit contamination for maximized uptimes with enhanced usability features from a simplified engineering design built from the legacy of the Turbo V source. Coupled with the calibration delivery system for fast, automated calibrations across the flow rate ranges.

Footprint
System - Exterior USP (Footprint)

Footprint

Reliable and robust accurate mass benchtop MS system. Requiring very little lab space, occupying occupies less lab space than any other HRMS on the market today.

H: 112cm W: 67cm W: 142cm
Software
System - Exterior USP (Software)

Software

Powered by SCIEX OS mass spectrometry software, intuitive algorithms and automation enable you to make informed decisions quickly. Transform your LC-MS/MS workflows with remarkable quantitative usability, efficiency, and integrity that streamlines your entire lab.

ION Path
System - Exterior USP (ION)

Ion Path

Designed to be powerful and versatile delivering enhanced performance for qualitative and quantitative workflows.

Calibration delivery system
System - Exterior USP (ION)

Calibration delivery system

Designed with a new calibration solution that automates mass calibration, and ensures mass accuracy of the system is maintained throughout acquisition.

Order Calibration Standards Order Calibration Standards

Ion Sources

Advanced source designs that limit contamination for maximized uptimes with enhanced usability features from a simplified engineering design built from the legacy of the Turbo V source. Coupled with the calibration delivery system for fast, automated calibrations across the flow rate ranges.

Footprint

Reliable and robust accurate mass benchtop MS system. Requiring very little lab space, occupying occupies less lab space than any other HRMS on the market today.

H: 112cm D: 142cm W: 67cm

Software

Powered by SCIEX OS mass spectrometry software, intuitive algorithms and automation enable you to make informed decisions quickly. Transform your LC-MS/MS workflows with remarkable quantitative usability, efficiency, and integrity that streamlines your entire lab.

Ion Path

Designed to be powerful and versatile delivering enhanced performance for qualitative and quantitative workflows.

Calibration delivery system

Designed with a new calibration solution that automates mass calibration, and ensures mass accuracy of the system is maintained throughout acquisition.

Order Calibration Standards Order Calibration Standards
The System Exterior
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The System interior
EAD cell
System - Interior USP (EAD Cell)

EAD cell

Highly tunable electron activated dissociation (EAD) allows for a range of free electron- based fragmentation mechanisms within one device.

TOF
System - Interior USP (EAD cell)

TOF

N-optic TOF design provides optimal mass accuracy and resolution without compromising sensitivity.

Heated TOF path & drone heaters
Mass Range: 40 to 40 kDa in TOF
Resolution: ≥ 42k at m/z 956
MS/MS Speed: 133Hz
Mass Accuracy: <2 ppm RMS Ext., <1 ppm RMS
Int Positive & Negative LDR:>5 orders Inter-scan LDR

Zeno trap
System - Interior USP (EAD Cell)

Zeno trap

Improved MS/MS duty cycle gain with 5-20X gain in MS/MS sensitivity coupled with either EAD or CID fragmentation

Q0 Design
System - Interior USP (EAD Cell)

Q0 Design

Improved ion optics design for ion capture and transmission, with easy access for maintenance.

LINAC collision cell
System - Interior USP (EAD Cell)

LINAC collision cell

High drive frequency collision cell provides better ion transmission, higher duty cycle, and improved resolution by focusing ions prior to entering TOF.

EAD cell

Highly tunable electron activated dissociation (EAD) allows for a range of free electron- based fragmentation mechanisms within one device.

TOF

N-optic TOF design provides optimal mass accuracy and resolution without compromising sensitivity.

Heated TOF path & drone heaters
Mass Range: 40 to 40 kDa in TOF
Resolution: ≥ 42k at m/z 956
MS/MS Speed: 133Hz
Mass Accuracy: <2 ppm RMS Ext., <1 ppm RMS
Int Positive & Negative LDR:>5 orders Inter-scan LDR

Q0 Design

Improved ion optics design for ion capture and transmission, with easy access for maintenance.

Zeno trap

Improved MS/MS duty cycle gain with 5-20X gain in MS/MS sensitivity coupled with either EAD or CID fragmentation

LINAC collision cell

High drive frequency collision cell provides better ion transmission, higher duty cycle, and improved resolution by focusing ions prior to entering TOF.

The System Interior
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Zoom out

Flow rate

Flow rate
Flow rate
Turbo V source

Turbo V source

The SCIEX Turbo V source with a refined source design that limit contamination for maximized uptimes and providing the high- sensitivity across and wide range of flow rates (5 µL/min- 3 mL/min) and compound class coverage with quick interchange of modes between APCI and ESI.

Optiflow source

Optiflow source

The robustness and simplicity you’ve come to expect from traditional analytical flow with Turbo V can now be experienced in your high sensitivity microflow workflows. Intelligent probe and electrode design eliminates manual adjustments and minimizes source optimization for the 1 -200 µL/min workflows.

Optiflow Turbo V source

Optiflow Turbo V source

Uniquely allow the user to switch to nanoflow regimes for the highest sensitivity. Simple, plug-and-play nanoflow capability takes the hassle out of nanospray applications. Integrated column oven, nanoflow probe and electrodes allow easy setup of nanoflow applications with no need for optimization.

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Learning Hub

Learning Hub success programs provide LC-MS and CE training customized to meet your exact needs.

With a selection of training methods and certifications available, you can build a mass spectrometry program that is most suited to your lab and users.

Starting with a clear understanding of your desired learning outcomes, we aim to help you improve lab productivity and consistency by designing and delivering a program that is focused on knowledge advancement and retention.

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