For research use only. Not for use in diagnostic procedures.
Protein expression changes of individual cytochrome P450 (CYP450) isoforms can be directly measured using the CYP450 Protein Assay – Human Induction Kits and an LC/mass spectrometry workflow for high specificity, sensitivity, and accuracy. These kits have been developed to employ multiple reaction monitoring (MRM) analysis to quantify seven CYP450 isoforms that are key proteins for induction studies: 1A2, 2B6, 2C9, 2C19, 2E1, 3A4 and 3A5. Kits with varying numbers of isoforms are available: 1) the four-isoform kit (1A2, 2B6, 3A4 and 3A5), and 2) the seven-isoform kit (1A2, 2B6, 2C9, 2C19, 2E1, 3A4 and 3A5).
- Directly measure CYP450 induction at the protein level without expensive antibodies
- Measure individual CYP450 isoforms with high specificity, sensitivity, and accuracy
- Easy-to-use kits and methodology employ a common MRM workflow
- Results are equivalent to traditional mRNA or activity assays
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