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CESI 8000 Plus ESI-MS System
See What You've Been Missing with CESI-MS
Experience the revolutionary ESI-MS approach to discovering previously undetectable characteristics from the minutest amount of precious samples, faster than ever before. Whether using as a standalone capillary electrophoresis instrument or in conjunction with the power of mass spectrometry, the CESI 8000 Plus allows you to concentrate on your science rather than technology. You’ve worked hard to get your sample this far. Get the most from that precious material and hunt down the hidden information you couldn’t see before:
- Intact mAb charge variants with online MS detection
- Proteoforms & peptide PTMs such as those with multiple phosphorylation sites
- Challenging charged & polar metabolites/degradation products such as anionic and/or hydrophilic analytes
- Isobaric metabolites and glycans not resolved by traditional techniques
- Protein conformation and quantitation
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| Key Features | |
|---|---|
Zero Dead Volume |
Single continuous separation capillary is contained within the OptiMS cartridge |
Multi-Detection Capability |
In stand-alone CE mode, UV/VIS, PDA, or LIF detection can be selected |
Multiple Injections from Precious Samples |
Sample analysis from as little as 5 μL |
Expand the Reach of Your Mass Spectrometer
The integration of Capillary Electrophoresis with Electrospray Ionization into a single dynamic process within the same device brings new capabilities to researchers.
Go Beyond the Possibilities
The CESI 8000 Plus high-performance system delivers fast, efficient and unique separation selectivity with enhanced sensitivity, while simultaneously expanding coverage.
CE-MS: More Info, Less Sample
Learn why capillary electrophoresis - mass spectrometry (CE-MS) is an attractive microscale analytical technique for addressing biological questions inherently dealing with low amounts of material.
Isobaric Compounds
Simplify the analysis of isobaric compounds inadequately resolved with current methods.
Native Conditions
Study the molecular interactions and structure of your proteins and peptides under native conditions.
See More Than Ever Before
Expanded coverage allows you to see more than ever before.
Expand the Coverage
Reveal hydrophilic charged and polar compounds and increase sensitivity in your metabolome and glycome analysis, not possible with LC methods.
Uncover New PTMs
Confidently quantify and characterize proteoform and peptide PTMs, such as those with multiple phosphorylation and glycosylation sites.
More Dynamic, Efficient Processes
CESI-MS allows for a more robust system with ultra-low-flow < 10 nL/min, into the mass spectrometer resulting an overall increase in ionization efficiency.
Minute Sample Consumption
Samples are often limited in quantity. CESI-MS has nL sample consumption, leaving most of the material available for analysis by orthogonal techniques.
Streamline Your Workflow
Use the same method and reagents for multi-level characterization of protein therapeutics. Switch between pos and neg ion modes without changing setup.
Frustration Free
Open tube technology eliminates frustrations common with nanoscale techniques. No more minimizing dead volumes, or dealing with carryover and clogs.
| Key Features | |
|---|---|
Dimensions |
29.2 in (74.2 cm) H x 25 in (63.5 cm) W x 28.4 in (72.1 cm) D |
Portable Lab Bench |
36 in x 30 in (91.4 cm x 76.2 cm) |
Weight (uncrated) |
188 lbs (85.3 kg) |
Electrical Requirements |
Voltage: 100 - 240 V; 50/60 Hz |
Sample Trays |
2 x 48 CESI vials / 0.3 mL microvials |
Buffer Tray |
2 x 36 CESI vials |
Pressure Delivery Range |
-5 to +100 PSI |
Required Sample Volume |
5 μl when using NanoVias |
See Why There’s Nothing Else Like the CESI 8000 Plus
Empower your PA 800 Plus with the SCIEX Empower Driver version 1.3
Take control of your PA 800 Plus with Waters Empower 3 Chromatography Data Software (CDS) for data integrity compliance. Reduce regulatory risk and maximize method transfer efficiency with the newly released SCIEX Empower Driver version 1.3.