Echo MS

Don't Compromise

This Acoustic Ejection Mass Spectrometry (AEMS) system balances unyielding data quality, speed, and cost: adding significant value to your high-throughput screening laboratory. The system combines industry leading, quantitative MS based detection with ultra-fast, contactless sampling capabilities, the Echo® MS can help redefine your current and future high-throughput workflows.

Redefining high-throughput quantification workflows.

Quality

Deliver high quality Z' values and data quality by minimizing sample handling, reducing carryover, and greatly diminishing the effects of suppressive buffers. Drive key go/no-go decisions earlier in your projects. Go from weeks to a matter of days, all while retaining the precise, information-rich information needed to make decisions about your lead compounds.

Precision

Achieve unparalleled standards of quantification. The Echo MS system provides consistent and precise reproducibility in challenging matrices. Its high specificity enables confidence in results and limits the needs for re-runs, all while saving on reagent costs compared to other technologies.

Speed

Conquer throughput barriers and decrease overall turnaround time with sampling speeds of at least 1 sample per second. Screen substrate and product simultaneously and reduce the number of iterations in your process. With the combined power of Acoustic Droplet Ejection (ADE) and Open Port Interface (OPI), the Echo MS decreases your cost/sample while maintaining the data quality you need.

Explore the Echo MS system.

Echo MS module

A pioneering combination of Acoustic Droplet Ejection (ADE) and the Open Port Interface (OPI) enables ultra-fast, contactless sampling, and worry-free, efficient integration into full automation solutions.

SCIEX Triple Quad 6500+ mass spectrometer

With its high sensitivity and wide linear dynamic range, the industry-proven SCIEX 6500+ system can deliver accurate quantification of both small and large molecule classes in diverse, complex matrices.

Acoustic Droplet Ejection (ADE)

ADE technology delivers nanoliter droplets in a contactless manner with high speed, precision and accuracy.

Open Port Interface

The OPI is a continuous-flow, self-cleaning, simple and versatile sampling interface for liquid introduction to atmospheric pressure ionization mass spectrometry. Directly eject complex samples with no sample loss or carry over, and overcome the typical challenges of liquid chromatography.

Echo MS probe

Intelligent probe sensing technology automatically adjusts the settings for the system source to an optimal range for best spray conditions, eliminating manual adjustments on the source and decreasing optimization time.

SCIEX OS software

With enhanced data acquisition and automated processing productivity, the compliance-ready software enables seamless implementation and operation of the Echo MS system in your high-throughput laboratory set-up.

OptiFlow Turbo V ion source

The zero-touch optimized source requires no manual adjustment to optimize the spray.

Acoustic Droplet Ejection (ADE)

ADE technology delivers nanoliter droplets in a contactless manner with high speed, precision and accuracy.

Open Port Interface

Echo MS probe

SCIEX OS software

OptiFlow Turbo V ion source

The zero-touch optimized source requires no manual adjustment to optimize the spray.

What the experts say...

Speed is very important and in some situations even crucial. If you think about processes where you have to make a decision within hours or less, then it makes a very big difference.

Thomas Hankemeier Professor of Analytical Biosciences, University of Leiden, Netherlands

Having data same day is a very big step. In terms of what the decision makers are getting, they are literally shipping the compounds and potentially getting results the same day.

Simon Wood Head of Analytical Science, Cyprotex. Macclesfield, UK

Resource Library

Pharma
Technical Notes
New

Development of an acetylcholinesterase biochemical assay using the SCIEX Echo^® MS system

Biochemical assays are frequently used in drug discovery to monitor enzyme activity and drug potency. These assays are of particular importance in the assessment of potential safety liabilities of new drug candidates. The accurate and timely reporting of these data is critical for decision making within pharmaceutical research. Here, the SCIEX Echo MS system was used as a detection technique for a routine acetylcholinesterase (AChE) biochemical safety assay.

Pharma
Technical Notes
New

Accelerating turnaround time in high-throughput ADME pipelines

A short read on AEMS technology for ADME screening. Here we discuss automated method building with existing DiscoveryQuant databases, automated batch submission, and data analysis to take advantage of the speed benefits of the LC-free Echo MS system.

Pharma
Technical Notes
New

Up to 10x increased throughput for metabolic stability assays

Move metabolic stability studies earlier in your pipeline! The Echo MS system enables high-throughput ADME to run 10x faster than traditional LC-MS/MS techniques with the same reproducibility and quantitative performance.

Pharma
Technical Notes
New

Automating high-throughput ADME assays on the Echo^® MS system

Read how the Echo MS system with LeadScape® Analyze 3.0 software is an excellent HT-ADME solution using very low sample consumption, no LC system components, and low operating costs that can support larger studies, test more lead compounds, and accelerate drug discovery.

Technology
Technical Notes

Rapid MS/MS analysis with Acoustic Ejection Mass Spectrometry (AEMS)

SCIEX Echo MS system breaks bottlenecks in quantitative mass spectrometry throughput. Here we demonstrate rapid, chromatography-free MS/MS analysis. It showcases the potential to dramatically change the field of high-throughput analysis.

Pharma
Technical Notes

Accelerated pharmacokinetic profiling and metabolite monitoring using Echo^® MS system

This technology note demonstrates the utility of this high-throughput solution for early discovery phase studies. The Echo MS system can overcome the analytical bottlenecks of traditional LC-MS solutions through speed and quantitative performance.

Synthetic biology
Technical Notes

High-throughput metabolite quantification for synthetic biology

Here, a quantitative approach for the rapid screening of 90 yeast strains using the Echo MS System was demonstrated, monitoring over 60 metabolites. The goal of publishing this workflow is to demonstrate the ability of the Echo MS System to rapidly screen a biological matrix for key metabolites of interest with significantly reduced analysis times..

Pharma
Technical Notes

True high-throughput bioanalysis using the Echo^® MS System

See how the Echo MS system provides throughput benefits for early-stage bioanalytical studies. Minimal and no sample preparation options are compared, with the results showing sample prep is not always necessary to achieve good results. The speed and simplicity of analysis of the Echo MS platform make it an attractive approach for high-turnaround bioanalytical laboratories.

Pharma
Technical Notes

Ultra-fast, accurate and simultaneous quantification of ritonavir and lopinavir in human plasma

The Echo MS system redefines quantitative mass spectrometry throughput. Here, the system delivers very sensitive, accurate and reproducible results for the simultaneous quantitative analysis of 2 protease inhibitors in human plasma. The very short analysis time (3 sec/sample) and method robustness enable scaling up the number of samples for such quantitative analysis.

Synthetic biology
Technical Notes

Rapid quantitative analysis of fermentation broth samples to assess efficiency of engineered yeast strain turnover

In the field of synthetic biology, the ability to quickly evaluate thousands of microbe strains to produce target compounds is critically important. Here, the Echo MS system is used to rapidly analyze peptide therapeutics in a common fermentation broth, showing the potential impact of this analytical platform on strain selection turnaround time in addressing this bottleneck.

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Learning Hub

Learning Hub success programs provide LC-MS and CE training customized to meet your exact needs.

With a selection of training methods and certifications available, you can build a mass spectrometry program that is most suited to your lab and users.

Starting with a clear understanding of your desired learning outcomes, we aim to help you improve lab productivity and consistency by designing and delivering a program that is focused on knowledge advancement and retention.

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Echo® MS system

Don't Compromise