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Characterize Therapeutic Proteins with Confidence on the PA 800 Plus
Perform Consistent and Compliant Biotherapeutics Characterization Faster than Ever
With the PA 800 Plus Pharmaceutical Analysis System, you can confidently safeguard the success of your biologics. Run multiple characterizations from a single system that biopharma labs depend on, and produce qualitative and quantitative analyses, with speed and confidence.
The PA 800 Plus is a robust analytical platform that can help you with:
- Monoclonal Antibody Applications
- Purity/Heterogeneity with Gold Standard CE-SDS in minutes
- Glycan Analysis with award-winning Fast Glycan Technology
- Charge Heterogeneity with fast and simple CZE or with hi-res cIEF
- Peptides and Proteins beyond mAbs
- Cell and Gene Therapy Applications
- Capsid Proteins Purity
- Nucleic Acid and Plasmid Analysis
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CONTACT SUPPORT
| Key Features | |
|---|---|
Multiple Applications, One Platform |
Run multiple protein characterizations from a single system to improve your operational efficiency and effectiveness. |
Raw Unmanipulated Data |
Have the confidence critical to both you and regulatory agencies for product submission and commercialization with raw, unmanipulated data. |
Reproducibility Matters |
Get repeatable results with exclusive recirculating liquid coolant to control separation temperature precisely. |
Portability Matters |
Easily transfer methods using robust, automated assays with proven portability ‐ ideal for global multi-user, multi-instrument. |
Precision Analytics for Oligonucleotide, Cell and Gene Therapy
As the technologies for manufacturing and analysis of gene therapy products continue to evolve, it’s important to keep up to date on growing industry trends and analytical advancements. This compendium can help advance your gene therapies and oligonucleotide therapeutics to the next level with the latest tools and methods.
Biologics Characterization Results You Can Trust
Characterize molecules, large or small, with industry and regulatory compliant capillary electrophoresis (CE) technology. It’s why every biopharmaceutical company with therapeutic IgGs currently on the market uses SCIEX CE systems in their bioanalytical processes.
Transferability
Develop and lock-down methods applicable to QC or regulated environments. Easily transfer methods using robust, automated assays with proven portability. Perfect for the global multi-user and multi-instrument organizations.
EZ-CE Cartridge
The convenient EZ-CE cartridge is ready-to-use across multiple applications. Enhance data consistency and minimize staff training with the PA 800 Plus EZ-CE cartridge.
Industry and Regulatory Proven CE Technology
The PA 800 Plus Pharmaceutical Analysis System is a robust analytical platform so you can have confidence in your data, without sacrificing speed.
Increase Efficiency
Running multiple assays on one platform simplifies staff training, maximizes ROI and reduces laboratory footprint.
Trust Your Assays
Extensive intercompany studies demonstrate the robustness of SCIEX capillary electrophoresis assays, encompassing CE-SDS, cIEF, CZE, and glycan analysis.
Simplify Compliance
The USP has included validated procedures and system suitability criteria for IgG Purity and heterogeneity analysis by capillary electrophoresis.
Maximize Sensitivity
Achieve as low as 0.01% impurity detection, with at least three orders of magnitude of impurity, with modular detection (UV, PDA, LIF)
Automated and Quantitative Analysis of Biotherapeutics
Generate highly reproducible data with PA 800 Plus quantitative and automated solutions. Our engineers have collaborated closely with biopharma development and QC groups experienced in biologics characterization to create assays that address your analytical challenges.
Protein Purity Analysis
Quantitative Protein Purity Analysis with SDS-Gel Capillary Electrophoresis
Glycan Analysis
Run glycans faster than HILIC with simplified sample preparation, rapid, high-resolution separations, and automated glycan identification.
Charge Heterogeneity
Conduct advanced capillary isoelectric focusing (cIEF) and hi-speed capillary zone electrophoresis (CZE) for charge heterogeneity analysis.
Peptide/Protein Characterization
Analyze peptide and protein biotherapeutics beyond mAbs.
SCIEX Biopharma Symposium
Gain access to on-demand content that highlights beginning to advanced capabilities of the PA 800 Plus. Visit our Biopharma Symposium to learn more.
Glycoprotein to Identified Glycans within Record 90 minutes
SCIEX Fast Glycan Labeling and Analysis delivers rapid glycan heterogeneity identification, capable of profiling your glycans in record time. Read all about our Fast Glycan Technology.
Video Length
Empower your PA 800 Plus with the SCIEX Empower Driver version 1.3
Take control of your PA 800 Plus with Waters Empower 3 Chromatography Data Software (CDS) for data integrity compliance. Reduce regulatory risk and maximize method transfer efficiency with the newly released SCIEX Empower Driver version 1.3.
Windows 10 Upgrade
We Are Now Windows 10 Compatible! Upgrade Your SCIEX CE Instruments Today.
Kit-based Assays
Get the reagents you need to run your experiments with one of the broadest selections of kit-based assays.
EZ-CE Cartridge
The convenient EZ-CE cartridge is ready-to-use across multiple applications.
Connect to a Mass Spec
Integrate CE with electrospray ionization (ESI) and connect to a mass spec with the CESI 8000 Plus.
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| Specifications | |
|---|---|
| A66528 PA 800 Plus Pharmaceutical Analysis System | Includes separation module with UV, photodiode array and LIF detection; system controller with PA 800 Plus software; system startup kit and reagents |
| A66527 PA 800S Plus Pharmaceutical Analysis System | Includes separation module with photodiode array detection; system controller with PA 800 Plus software; system startup kit and reagents |
| Dimensions | Height: 29.2 in (74.2 cm) Door Open: 38.8 in (98.6 cm) Width: 25 in (63.5 cm) Depth: 28.4 in (72.1 cm) |
| Weight (uncrated) | 188 lbs (85.3 kg) (includes photodiode array detection) |
| Electrical Requirements | Voltage: 100 - 240 V; 50/60 Hz |
| Voltage Range | 1 to 30 kV programmable at 0.1 kV increments |
| Current Range | 3 to 300 μA programmable at 0.1 μA increments |
| Pressure Delivery Range | -5 to +100 psi |
| Sample Temperature Control | 4 - 60°C |
| Capillary Temperature Control | 15 - 60°C |
| Sample Trays: 2 x 96-well plates | 2 x 48 universal vials 2 x 48 0.2 mL microvials |
| Buffer Tray | 2 x 36 universal vials |
| Detection Capability | UV/Vis 200, 214, 254, 280 nm standard filter 190 - 600 nm (custom filter option) Diode Array 190 - 600 nm (programmable) 0.5 - 32 Hz scan collection frequency (programmable) Laser Induced Fluorescence (LIF) 300 - 700 nm excitation range 350 - 750 nm emission range 0 - 1000 RFU |
| Source Lasers with 3 mW Power Output | 488 nm solid-state laser (included in A66528) |
| Learning Center | |
|---|---|
| Installing the LIF Aperture and Probe Guide/Stabilizer Step-by-Step Video Guide | Watch |
| Cartridge Removal, Rebuild and Reinstallation Step-by-Step Video Guide | Watch |
| Change the Coolant Tubing Step-by-Step Video Guide | Watch |
| Change a Detector Step-by-Step Video Guide | Watch |
| Capillary Removal Step-by-Step Video Guide | Watch |
| Capillary Storage Step-by-Step Video Guide | Watch |
| CE-SDS MW Application Guide | Download |
| Glycan Analysis Application Guide | Download |
| Fast Glycan Software | Download |
| Sample Preparation for the Fast Glycan Technology on the PA 800 Plus | Watch |
| Fast Glycan Sequencing Using a Fully Automated Carbohydrate Sequencer | Download |