New approaches to characterizing post-translational modifications of charge isoforms

Critical information on drug molecules at the intact level can reduce risk and streamline both downstream and upstream processes. This can be achieved by reducing the time required to gain this information and enabling the use of mass spectrometry assays at critical stages in early development.

Characterization of icIEF charge isoforms, whether in early product development or associated with licensure filings, is usually achieved through ion exchange (IEX) liquid chromatography followed be mass spectrometry.

The Intabio ZT system supports a fully integrated icIEF-UV/MS workflow on one platform and can enable the direct characterization of specific species in the icIEF electropherogram, eliminating the need for extensive method development. 

In this webinar, you will:

• Discover opportunities to advance core platform technologies with novel characterization approaches
• Hear case studies on understanding molecular structure information
• New approaches to characterizing post-translational modifications of charge isoforms