ZenoTOF 8600 system

Extraordinary performance in both core and transformative workflows

The ZenoTOF 8600 system represents a leap forward in mass spectrometry, offering noteworthy sensitivity and precision. Performance that lets you do more with a single system; sensitivity and functional speed improvements in MS1 and MS2 enhance data quality across many workflows.

Up to 10x sensitivity*

With up to 10x greater sensitivity in MS1 and MS2 and the integration of SCIEX triple quad technology, this system enables precise identification and fast, sensitive quantitation of low-abundance biomolecules across targeted, DIA, and DDA methods, achieving up to 10-fold lower LOQs and a dynamic range spanning up to 5 orders.

* Compared to the ZenoTOF 7600+ system

Discover more with comprehensive data analysis

ZT Scan 2.0 DIA offers high-speed, broad molecule support with enhanced Q1 window selectivity for improved quantitative accuracy and identification, while its extended mass range makes it the most comprehensive and high-throughput SWATH DIA solution for all molecule types.

Deliver on important timelines

Sensitivity and performance-driven speed enhancements maximize throughput and enable faster acquisition of high-quality EAD spectra (extended into negative ionization with up to 50 keV), unlocking rapid data-dependent acquisition for deeper insights into lipid biology, protein modifications, and metabolite structures.

Transforming data into actionable insights

SCIEX OS 4.0 software streamlines and enhances workflows across the ZenoTOF 8600 system with innovative features for method development, real-time QC, and data acquisition, while strategic integrations with tools like PEAKS, DIA-NN, and MS-DIAL deliver optimized insights for proteomics, metabolomics, and lipidomics research.

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Key features

Ionization source

The OptiFlow Pro ion source incorporates the reliability and efficiency of the Turbo V ion source while providing flexibility for quickly switching flow rates.

Scan speeds of up to 858 Hz

The fastest SCIEX QTOF yet! When using ZT Scan 2.0 DIA, the isolation window for MS/MS slides along the m/z range of interest during each cycle. With a quadrupole scan speed of up to 4000 Da/s, the system can operate at a MS/MS scan rate of up to 858 Hz, dependent on the pre-defined mass range, (not accounting for multiple precursors in a single isolation encoded window.

Mass Guard technology with optical detector

The novel combination of Mass Guard technology and a new optical detection system allows the instrument to operate effectively at higher ion currents while protecting it from contamination.

ZT Scan 2.0 DIA for all molecule types

The flexibility in mass range and compound parameters extends functionality across diverse workflows, including small molecule analysis. Methods are easy to set up and require minimal user optimization, facilitating the analysis of large sample cohorts.

High-energy EAD

Acquire higher-quality EAD spectra faster across all molecule types*. Perform CID or EAD profiling on equivalent timescales, gaining deeper insights into lipid biology, protein modifications, and metabolite structures. Extend electron-based fragmentation capabilities into negative ionization with up to 50 KE.

ZenoTOF versatility

Zeno trap can be enabled to deliver enhanced sensitivity. Ions are accumulated in the Zeno trap before being pulsed rapidly into the TOF, meaning we can detect up to 20x more ions than a classical QTOF design.

Integrated innovation

SCIEX OS 4.0 software enables users to track instrument performance, instrument health and enhanced automated system tuning, helping to ensure that users can easily attain and maintain optimum performance from their system.