Exploring challenging molecules, compounds and solutions in analytical quantitation
High stakes lead to bigger rewards for companies and individuals who tackle tough challenges in analytical quantitation. Each month, the Spotlight on series will highlight a different challenging molecule or class of compounds as well as related LC-MS solutions, unmatched in terms of sensitivity and accuracy, that will help customers meet today’s and future needs. So far the series has taken a deep dive into the following molecules: nitrosamines, targeted protein degraders (TPDs), lipid mediators, PFAS (poly-and perfluoroalkyl substances), fentanyl, and bile acids. You can choose the molecule of interest when you log-in to learn more.
Next up in the Spotlight on series, lets explore GLP-1 . They seem to be everywhere right now! Check out this quick read, designed to help you gain a deeper understanding of GLP-1 and the role of LC-MS in their research and analysis.
These brief, focused learning sessions are a quick read, designed to help learners gain a deeper understanding of each molecule and the role of LC-MS in their research and analysis.
GLP-1 is a multifaceted hormone that regulates blood glucose, influences appetite and weight, and provides cardiovascular benefits. Continued research and development of GLP-1-based therapies promise to advance and expand potential uses.
The sensitivity, specificity, and versatility of LC-MS plays a major role in advancing GLP-1 research with new insights.
Until recently, the biochemistry of bile acids was relatively poorly understood. But thanks to the rising visibility of the importance of the microbiome in the gut-brain axis, renewed interest has prompted many new studies.
This stems from bile acids central role in a variety of biological processes and their potential as therapeutic targets and biomarkers. Explore how the power of LC-MS progresses new insights and drives forward the frontiers of bile acid research.
Estimated to be 50 to 100 times more potent than morphine, understanding the pharmacology of fentanyl is crucial for developing better safety protocols and treatments. The urgency of the fentanyl crisis has spurred a wide range of research efforts aimed at reducing its harmful effects and improving public health outcomes.
PFAS are present in so many facets and aspects of everyday life and have a huge short- and long-term impact on the environment, human exposure, and future health. Therefore, workflows must be adaptable and robust enough to analyze various sample types for PFAS. LC-MS is considered the gold standard for detecting and quantifying PFAS molecules and has become the “defacto” methodology for analysis.
Learn more about how LC-MS is providing the sensitivity needed to study these “forever chemicals.”
Lipid Mediators: by using LC-MS, researchers can better understand how lipid mediators regulate inflammation and other biological processes, potentially leading to new therapeutic strategies for a variety of diseases.
LC-MS is a powerful analytical technique that allows for the precise identification and quantitation of lipid mediators, even at very low concentrations. The high sensitivity and specificity of LC-MS make it an indispensable tool for studying the complex and often fleeting nature of these signaling molecules.
Explore how targeted protein degraders offer a unique and powerful strategy to address diseases by eliminating harmful proteins at their source and have the potential to target proteins previously considered “undruggable” by traditional methods.
See how SCIEX is helping scientists figure out best practices for LC-MS analysis, and gain access to featured technical notes and webinar.
Get a deeper understanding of what makes nitrosamines a concern, what is being done to understand and test for nitrosamines, and how SCIEX LC-MS solutions can help give you confidence in your quantitation needs: for today and tomorrow.
And gain access to featured technical notes and material related to the detection of nitrosamines in metformin, losartan and in 6 food matrices as well!