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In recent years, oral fluid has gained considerable attention as a quicker and less invasive means of monitoring cannabis use. More specifically, the use of this matrix for drug testing benefits from ease of sampling, observed collection and difficulty of sample adulteration. Here we demonstrate the key advantages of the SCIEX Triple Quad 7500 System – QTRAP Ready for sensitive detection of THC-COOH in oral fluid.

Here, a rapid, robust, and sensitive method for the detection and quantification of common Z drugs and their metabolites in human urine is described. Their degradation profile under different conditions was also investigated using both the SCIEX Triple Quad 5500+ System – QTRAP Ready and the SCIEX X500B QTOF System. The combination of the two systems enabled accurate and sensitive quantification of Z drugs and metabolites while providing confident identification of the degradation by-products.

As the surge of novel synthetic opioids and other synthetic drug classes continue to pose serious public health and safety problems, timely and comprehensive drug screening approaches are critically needed in the forensic laboratory to quickly and accurately identify these emerging novel substances. The combination of LC separation coupled to tandem mass spectrometry detection (e.g., LC-MS/MS, LC-QTOF-MS) provides forensic investigators the speed and confidence required to reliably identify novel drugs of abuse and other toxicology compounds present in a variety of complex matrices.

The measurement of aldosterone by LC-MS/MS poses some specific analytical challenges due to the low concentrations of this compound. The unique MRM3 scan available only on QTRAP systems was investigated with a goal of improving sensitivity and reducing background interferences.

The recent outburst of novel synthetic opioids (NSO) into the recreational drug market has been a major contributor to the ongoing opioid crisis. As a result, the widespread availability of these substances continues to pose major safety concerns for public health and law enforcement officials alike. In this technical note, a comprehensive workflow is presented combining the use of the SCIEX X500R QTOF System with a simple extraction procedure for specific and sensitive detection of fentanyl analogs and synthetic opioids in hair.

The SCIEX 7500 System is presented as a robust quantitative platform with exceptional performance in speed and sensitivity for the accurate quantification of a panel of 32 novel synthetic opioids (NSO), including fentanyl analog isomers in human whole blood. The optimized method maximizes the quantitative performance of the system while retaining the required levels of accuracy, precision and quantitative performance. The addition of new hardware features of the OptiFlow® Pro Ion Source, the D Jet™ Ion Guide and the E Lens™ Technology enhance ion sampling and desolvation, resulting in unparalleled sensitivity and quantification limit improvements for the 32 NSO targeted in this study.

A comprehensive workflow for the detection of 6 antipsychotic drugs in serum was successfully developed using the SCIEX QTRAP® 4500 system. The combination of an efficient sample preparation procedure and a fast and robust acquisition method enabled accurate detection of the antipsychotic drugs in serum samples.

Here, a quantitative workflow for the analysis of 22 PFAS compounds in serum was developed using the SCIEX QTRAP 6500+ System. This targeted screening workflow provides a fast analytical method capable of accurately quantifying sub-nanogram per mL levels of PFAS in the human body. Here we provide the names, formulas, structures, and CAS number of the analytes of interest and standards used in the method, information regarding the LC and MS conditions and parameters, consumables and other materials needed to run the method, relevant training courses and other useful information.