Antibody-drug conjugates (ADCs) are one of the rapidly growing classes of the biopharmaceutical market and formed by the conjugation of various drug species to a monoclonal antibody. Effective characterization methods for ADCs are needed to ensure the stability and efficacy of the drug because the complexity and heterogeneity of the ADC structure itself increase the process of linking the payload to the protein backbone.

Key learning points:

• Understand critical ADC characterization techniques, including cIEF and high-resolution mass spectrometry
• Learn how the Intabio ZT system and the ZenoTOF 7600 system integrate to provide detailed charge variant profiles and structural insights
• Explore practical case studies showcasing the application and benefits of these advanced technologies in ADC research and development