Capillary electrophoresis (CE) is a powerful analytical technique widely used to assess the quality of biopharmaceuticals. While it was originally developed to profile protein drug impurities for quality control, its applications have significantly broadened. Today, CE plays a crucial role in analyzing RNA and DNA products in both quality control and process development samples.

In this presentation, you'll explore how CE has evolved and discover its expanding role in modern biopharmaceutical analysis.

Discussion points:

  1. CE-SDS in adeno-associated virus analysis:
    • Learn how scientists utilize CE-SDS to analyze adeno-associated virus (AAV) in process samples
    • Understand how this technique helps calculate viral particle titre and accurately size the viral proteins essential for building viral particles
  2. Capillary gel electrophoresis (CGE) for ssDNA payload profiling and mRNA analysis:
    • Explore using CGE the profiling of active single-stranded DNA (ssDNA) payload within the same process samples
    • Gain insights into the precision and efficiency of CGE in quality control
    • Understand some of the factors that affect mRNA analysis
  3. New consumable kit for plasmid purity profiling:
    • Discover the latest advancements in CE chemistries with a new consumable kit designed to profile the purity of plasmids used in viral particle construction

Speaker:

Dr Steve Lock

Steve, a chartered chemist with a PhD in Physical Organic Chemistry, has over 25 years at SCIEX. Presenting at 100+ international meetings, he collaborates with biopharmaceutical industry customers and is an Adjunct Professor at the University of Pannonia.

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