Widely applicable charge variant analysis of therapeutic proteins

Analytical charge variant analysis methods require time-consuming development times and results are not always ideal. HPLC-based ion-exchange methods need to be optimized, and capillary electrophoresis-based charge variant methods do not always generate data that trends as well as native analysis.

In this study, we present a native state analysis that delivers high resolution results in as little as 5 minutes. This platform method can easily be applied to a wide array of therapeutic proteins such as antibody drug conjugates (ADCs), mono- and multispecific antibodies, and fusion proteins.

You will:

  • Learn about a robust, reliable and validated method for rapid charge variant analysis
  • Simplify your charge heterogeneity sample prep with minimal development time
  • Discover high resolution, kit-based solutions to elevate your charge variant applications

Who should attend:

  • Lab scientists or managers working with therapeutic proteins


Peter Holper

Application Scientist, SCIEX

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