Analytical charge variant analysis methods require time-consuming development times and results are not always ideal. HPLC-based ion-exchange methods need to be optimized, and capillary electrophoresis-based charge variant methods do not always generate data that trends as well as native analysis.
In this study, we present a native state analysis that delivers high resolution results in as little as 5 minutes. This platform method can easily be applied to a wide array of therapeutic proteins such as antibody drug conjugates (ADCs), mono- and multispecific antibodies, and fusion proteins.
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Application Scientist, SCIEX