SCIEX summit

Jamie joined SCIEX 20 years ago and has held multiple technical and leadership roles throughout his career at SCIEX.  Starting out as an engineer in manufacturing operations, Jamie has since led teams in supply chain, product development, and most recently the research and product applications teams within R&D. Prior to joining SCIEX, Jamie worked at JDS Uniphase as an optical test engineer.

Jamie holds a B.Sc. in engineering physics from Queen’s University. 

Tatjana is a Senior Product Manager at SCIEX, overseeing accurate mass systems since 2021. She collaborates with R&D, sales, and marketing teams to ensure effective project execution and portfolio management.

Previously, Tatjana was a Product Manager at MOBILion Systems, leading the pre-commercialization of SLIM-based ion mobility instruments. She also has held roles at Thermo Fisher Scientific as a Sr. Vertical Marketing Specialist and Sr. Field Applications Scientist.

Tatjana holds a B.A. in chemistry from Austin College and a Ph.D. in biomedical sciences and biochemistry from the University of North Texas Health Science Center.

With over ten years in product development, Ian is the Senior Technical Product Manager for nominal mass LC-MS/MS systems at SCIEX. He has also served as a Technical Product Manager and Global Technical Marketing Manager. Ian began his SCIEX career as an Application Scientist, focusing on biologics bioanalysis and DiscoveryQuant software validation.

Before SCIEX, Ian was the Lead Analytical Scientist at Custom Biologics, overseeing LC-MS/MS method development and clinical trial analysis. He also served as a Senior Scientist at Affinium Pharmaceuticals, focusing on metabolic stability profiling and enzyme inhibition assays.

Ian holds a postdoctoral position at McMaster University, specializing in antibiotic resistance and enzyme inhibitor screening

Tuesday, September 24
12:05 pm EDT

Learn how utilizing a research-grade Zeno-trap time-of-flight LC-MS system can advance current applications in immunopeptidomics and proteomics, including:

• What is ZT Scan DIA, the technology and how it benefits data acquisition
• Preliminary proteomics and immunopeptidomics results using ZT Scan DIA
• Future applications of immunopeptidomics using ZT Scan DIA

Tuesday, September 24
12:40 am EDT

High-resolution mass spectrometry (HRMS) has long sought to be a viable alternative for quantitative workflows but has been unable to broadly compete, mainly due to the lack of suitable data processing software. In this work we describe:

• A molecular structure-dependent workflow
• The holistic and user-independent processesing of HRMS data
• The automatic quantification of small drug-like molecules

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Wednesday, September 25
10:55 am EDT

Routine measurement of metabolites and lipids has become a cornerstone of biomedical research. At the MPC, Helmholtz Munich, non-targeted analysis is based on the SCIEX ZenoTOF 7600 for accurate and in-depth analysis and annotation of metabolites and lipids from different biological specimens.

• Application of Zeno trap enabled non-targeted workflows to large scale metabolomics and lipidomics studies
• Enhanced sensitivity enables deeper profiling of biological samples
• Increased confidence in identifications through comprehensive structural elucidation using Electron activated dissociation (EAD)

Wednesday, September 25
10:20 am EDT

Learn about our top-down proteomics workflow for the characterization and quantification of calreticulin (CALR) arginylation. MS1 profile and MS2 fragmentation were characterized by EAD. Preferential fragmentation at the CALR N-terminals yielded sufficient c ions facilitating precise localization of the arginylation sites. Learn about: 

• Arginylation regulates CALR degradation and ER function
• EAD is efficient in characterizing N-terminal arginylation
• The workflow sets up the foundation for unbiased top-down activity-based arginylation profiling

Tuesday, September 24
10:20 am EDT

Highly sensitive mass spectrometers allow the advanced bioanalytical labs of today to achieve the LOQ required of potent biologic drugs and provide maximum flexibility in choice of sample prep techniques. However robust mass spectrometers are crucial for several reasons:

• Aid in ensuring the consistent quantitative performance of an assay
• Effectively allow a lab to meet their project timelines
• Are essential for handling the inherent variability of analyzing diverse molecules and diverse samples required for bioanalysis

Tuesday, September 24
10:55 am EDT

The combination of a super-fast sampling interface with the highly sensitive ZenoTOF 7600 system makes it an ideal system for evaluating covalent binding screens. Main findings in our experiments using the Echo® MS+ system:

• Speed: measurements from a full 384-well plate in 15 min or 1536-well plate in less than one hour
• Precision: low injection volume supports repetitive measurements and time series; capture full kinetic data set in one experiment
• Quality: high data quality allows for full automated processing, delivering immediate hitlist output

Tuesday, September 24
11:35 am EDT

Characterization of icIEF charge isoforms, whether in early product development or associated with licensure filings, is usually achieved through ion exchange (IEX) liquid chromatography coupled with mass spectrometry. icIEF-MS technology has recently emerged to enable the direct characterization of specific species in the icIEF electropherogram, eliminating the need for extensive method development. 

• Discover opportunities to advance core platform technologies with novel characterization approaches
• Hear case studies on understanding molecular structure information
• New approaches to characterizing post-translational modifications of charge isoforms

Tuesday, September 24
12:40 am EDT

High-resolution mass spectrometry (HRMS) has long sought to be a viable alternative for quantitative workflows but has been unable to broadly compete, mainly due to the lack of suitable data processing software. In this work we describe:

• A molecular structure-dependent workflow
• The holistic and user-independent processesing of HRMS data
• The automatic quantification of small drug-like molecules

Wednesday, September 25
11:30 am EDT

In DMPK development metabolite identification (metID) studies, in vitro and in vivo systems often produce heterogenous mixtures of metabolites. The analytical separation, quantitation, and accurate identification of these (phase I and II) metabolite structures is critical. The implementation of the ZenoTOF 7600 system to ADME workflows will be highlighted with emphasis on EAD fragmentation and (automated) data processing.

• Systematic evaluation of metabolites across different chemical classes by comparing conventional fragmentation modes (CID & HCD) with EAD fragmentation. Use of EAD to solve complicated chemical structures and localize biotransformations.

• In vitro workflows for Discovery ADME Applications to ID metabolic labilities.

• Incorporating mass defect filtering and isotope ratio filtering into data acquisition for in vivo ADME projects.

Wednesday, September 25
12:40 pm EDT

Guide decisions during cell line development with the Intabio ZT system with more information on how process changes affect cell line and product stability.  

• How to utilize icIEF-UV/MS to identify sequence variants
• How this information can be used to create a mitigation strategy
• What more information in less time means to groups throughout process development

Thursday, September 26
10:50 am EDT

Having the right information available at every stage of the process is vital to bringing safe and effective therapies to market.. SCIEX OS software is a vital component of this process, from discovery to development. See how: 

• Your pharma lab workflows can benefit from SCIEX OS software
• Central Admin Console enables comprehensive audit configurations for full traceability
• Professional services are available to assist in migrating from legacy Analyst software and change control support plansis

Tuesday, September 24
12:40 am EDT

High-resolution mass spectrometry (HRMS) has long sought to be a viable alternative for quantitative workflows but has been unable to broadly compete, mainly due to the lack of suitable data processing software. In this work we describe:

• A molecular structure-dependent workflow
• The holistic and user-independent processesing of HRMS data
• The automatic quantification of small drug-like molecules

Wednesday, September 25
12:05 pm EDT

Time-of-flight mass spectrometry has become a key tool in analytical laboratories involved in food analyses. This instrumentation can be used for both targeted and non-targeted approaches. In this presentation, we will discuss:

• Overview of practical targeted and non-targeted approaches in food analysis
• Application of a SWATH® approach to the analysis of pesticide residues in food
•  Application of IDA approaches in non-targeted food analyses

Thursday, September 26
10:20 am EDT

Biochemie Lab shares their expertise in veterinary drug analysis. With over 25 years of experience and strict adherence to Commission Regulation (EU) No 37/2010, Biochemie Lab processes more than 100,000 samples annually, providing comprehensive food and environmental testing.

• Learn how Biochemie Lab conducts veterinary drug testing with specialized veterinarians, covering a wide range of analyses, including residual veterinary drugs, anabolic substances, and microbiological tests. 
• Discover how they overcome challenges in analyzing complex animal-origin matrices like meat and offal using the SCIEX QTRAP 7500 system.
• Explore their proficiency testing, method validation results, and ask questions directly from leading experts in the field. 

Panelists include:

• Rathna Veeramachaneni, Director, Biopharma LC-MS/MS, KCAS Bio
• Xiaping He, Senior Scientist, Pfizer
• Markus Stöckli, Senior Principal Scientist, Novartis Institutes for BioMedical Research
• Tony Purcell, Professor, Monash University 
  
• Kevin Bateman, Retired Pharmacokinetics, Pharmacodynamics and Drug Metabolism Expert

Panelists include:

• Tom Lin, Instructor, Washington University in St. Louis
• Michael Witting, Deputy Head Metabolomics and Proteomics Core and Executive Manager Metabolomics,  Helmholtz Munich
• Francisco José Díaz-Galiano, Postdoctoral researcher, University of Almería
• Kirsten Nields, Principal Scientist, J&J Innovative Medicines
• Tatjana Talamantes, Senior Product Manager, Accurate Mass, SCIEX

Panelists include:

• Roberto Riccio, Biochemie Lab
• Shane Karnik, Senior Laboratory Director, Aliri Bioanalysis
• Ebru Selen, Biologics Applications Scientist, SCIEX
• Paul Baker, Senior Scientific Liason, Lipidomics and Metabolomics, SCIEX
• Craig Butt, Senior Manager, Scientific Marketing, Applied Markets, SCIEX