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Precision medicine unleashed
Webinar series
Unlock the secrets of personalized healthcare and a new era of precision medicine in omics
Welcome to our Precision medicine unleashed multi-part webinar series that delves into the fascinating world of mass spectrometry applications in lipidomics, proteomics and metabolomics. In this series, we will explore the power of the revolutionary technology around mass spectrometry and its immense potential to transform the field of precision medicine. From unraveling intricate lipid profiles to deciphering the complexities of proteomic landscapes and metabolite networks, we’ll uncover remarkable advancements and breakthroughs in these fields.
There are two sessions below that you may to register to watch now!
This webinar has been cancelled:
Precision metabolomics: Disease is just broken chemistry
Ready to watch:
Precision proteomics: A novel method for measurement of serum biomarkers for obesity research
Presenter: Aprajita Yadav, Isoherranen Lab at the University of Washington
Obesity, a growing public health concern, is linked to fatty liver and insulin resistance. Dysregulation of Vitamin A (retinol) homeostasis in obesity may contribute to related disorders, including diabetes and chronic kidney disease. Retinol binding protein 4 (RBP4), essential for mobilizing retinol from the liver, can form a complex with transthyretin (TTR) in blood, extending its half-life. The apo- to holo-RBP4 ratio offers insights into RBP4 signaling and homeostasis, yet traditional methods like western blots and ELISA fall short in accurately measuring these forms. The study presented in this webinar demonstrates a novel LC-MS/MS method used to quantify fasting serum RBP4, TTR, and retinoids in a non-diabetic population (n=31) with varying BMI. This method, validated to FDA Bioanalytical Guidance, shows <12% inter-assay variability and assesses the impact of different serum and plasma processing methods. Findings reveal mean concentrations of retinol, RBP4, and TTR, highlighting the potential of this method to investigate retinoid homeostasis in metabolic disorders.
Precision lipidomics: Targeted assays for genetic disorder monitoring
Presenter: Seul Kee Byeon, Assistant Professor, Mayo Clinic
The dysregulation of lipids plays a role in the development and progression of various genetic disorders such as Tay-Sachs, Sandhoff disease and Barth syndrome. The cause of these disorders is often a result of the deficiency of enzymes involved in lipid metabolism. This webinar explores the development of two distinct lipid assays that are underway to provide a more efficient and comprehensive approach to improve screening of various genetic disorders.