Benefits include:

  • Improved confidence in compound detection: monitoring accurate mass fragments provides unambiguous detection of target analytes

  • Reduced impacts from complex matrices and interferences: the enhanced specificity of high-resolution accurate mass precursor and fragment ions results in better data quality, lower LOQs and fewer false positives

  • Enhanced compound identification with MS/MS library matching: full MS/MS fragmentation spectra can be searched against databases to confirm compound identification

  • Retrospective analysis to find new chemicals of concern: non-targeted data—acquired via data-independent acquisition (DIA) with SWATH DIA, for example—can be reinterrogated without the need to reprocess or reanalyze samples