Drug testing can be performed in various biological matrices, such as urine, blood, saliva, sweat, hair, and nails. While urine and blood testing are most common, hair and nail testing are increasingly valuable for a broader picture of past drug use. Drugs incorporate into hair and nail keratin, offering a wider detection window and non-invasive sample collection. These samples are easy to transport and store, minimizing alteration and degradation. However, drug detection in hair and nails is challenging due to low drug concentrations, requiring sensitive instrumentation and extensive validation.

This webinar will discuss LC-MS/MS-based methods for drug analysis in keratinized matrices, demonstrating the need for high-sensitivity mass spectrometry for low-level drug detection. The results presented will highlight the benefits of performing hair and nail analyses using LC-MS/MS.

Key learnings in this webinar will include:

• Exploring the advantages of hair and nail testing to determine long-term drug exposure
•  Getting a clear understanding of the importance of method development and validation of LC-MS/MS-based methods to perform comprehensive drug analysis in keratinized matrices
•  Discovering the benefits of sensitive mass spectrometry instrumentation for the detection of low-level drugs and metabolites in keratinized matrices