Canned Calculation for SANTE Guideline 11312/2021v2- D8 Available for SCIEX OS Software

For research use only. Not for use in diagnostic procedures.

Issue Description

SCIEX provides pre-assembled calculation packages ('Canned Calculations') for use with processing methods created in SCIEX OS software for several common application workflows. These calculation packages can be used with SCIEX OS software version 2.1.6 and higher, depending on the used features, and contain the custom calculations and flagging rules needed to process data for a commonly-used application, such as the technical guidance for detecting pesticide residues in the European Union, SANTE 11312/2021v2.

This article provides information on the custom calculations required for processing data according to the guidance found in SANTE 11312/2021v2 – D8:

Resolution

The idea behind Canned Calculations for SCIEX OS software is to provide a ready-to-go, user friendly, data processing solution containing all the calculations and flagging rules that can be imported into a results table created in the Analytics workspace.
The calculations do provide a plug-and-play approach, but the resulting custom columns in the results table require some additional interpretation after applying the calculations. Each calculation in the package should be evaluated and adjusted to suit each lab's needs, they should apply their own insights when interpreting method guidelines, when identifying the samples used for the calculations, when presenting the results and when linking different calculations.

For identification of analytes with TripleQuad measurements according to the SANTE 11312/2021v2 – D8, SCIEX generated a set of calculations and flagging rules that provide custom columns which flag samples that show a S/N<3, a difference in RT for boths MRMs > 0.015 minutes or an ion ratio that differs from the mean ion ratio in the standard samples for more than 30%.  

The example result table below shows custom columns, generated with the canned calculations in SCIEX OS v3.4 using a default data set, that is available when you are logged in on our website at this link in 'SCIEX OS Resources':
https://sciex.com/support/software-support/software-downloads



Requests to obtain the canned calculation package for SANTE 11312/2021v2 – D8 can be made by opening a case with SCIEXNow, indicating which software version is used and referencing this article.