iMethod™ Application for Bisphenol, Octylphenol and Nonylphenol for Cliquid® Software (Partner Contributed)

For research use only. Not for use in diagnostic procedures.

iMethod Application for Bisphenol Octylphenol and Nonylphenol for Cliquid Software


Bisphenol A (BPA) is widely used in high-production volume manufacturing of polycarbonate plastics and epoxy resins. Current studies evaluating the impact of BPA on health and the environment have not reported conclusive results. Octylphenol (OP) and nonylphenol (NP) are degradation products of alkylphenol ethoxylates, a family of nonionic surfactants widely used in consumer and institutional cleaning products. The estrogenic and toxic effects of OP and NP have been well-studied and reported.

By using ultra high performance Rapid Separation (RS) LC-MS/MS, BPA, OP and NP in water samples can be analyzed much more rapidly than using a labor intensive sample derivatization GC-MS method. This RSLC-MS/MS method has a significantly shorter run time of just 5 minutes compared to 25 minutes using GCMS technology, and uses a small particle size 2.2µm analytical column to provide robust and reproducible high throughput analysis.

Method files (ZIP)

Activity Using an iMethod™ Application Traditional Method Development
Complete Test Protocol Documentation Included Weeks–Months
Sample Prep Techniques Included, with examples and references Weeks–Months
Optimized MS/MS Acquisition Parameters Included Weeks–Months
LC Instrument Parameters with Retention Times Included Days–Weeks
Integration (Quantitation) Parameters Included Days
Reporting Templates Included Days
LC/MS/MS Library Spectra May be included. Stand-alone libraries are also available. Weeks–Months
Staff Training – Software Simple Cliquid® Software interface, no additional training Traditional MS Software and review procedures – Days
Method Validation Weeks. Validation templates and support available Weeks–Months
Complete Test Development and Deployment Weeks 6–12 months