Dr. Martin Giera
Associate Professor, Head Metabolomics Group, Leiden University Medical Center (LUMC)
Project goal
To apply lipidomics to a variety of disease areas, such as inflammation, infection, obesity, and migraine in mechanistic as well as large-scale research studies involving thousands of samples.
Specifically, to carry out smaller projects on sepsis, intraperitoneal feeding and immune cell metabolism.
The challenges
- The ability to quantify the totality of lipids in our samples
- To robustly handle with high uptime complex biological samples
- Identifying thousands of lipids with confidence and avoiding the common challenge of isotopic and isobaric overlap
The solution
- A complete package for lipidomics analysis that can differentiate and quantify over a thousand lipid molecular species across 13 lipid classes of complex lipid metabolism.
The outcomes
- Generation of reproducible data from large-scale studies.
- Investigations of lipid remodelling during acute inflammation, the effects of bioactive lipids on the course of inflammation, and metabolic profiling in the field of biomarker discovery.
Type of organization
Metabolomics and Clinical Research Centre
Goals
To identify and measure lipids as biomarkers, and thereby find novel diagnostic and mechanistic disease markers.
Applications
Untargeted and targeted lipidomics, MRM quantification
SCIEX Products
- Lipidyzer™ Platform
- Lipidyzer Kits
- QTRAP® 6500 System
- SelexION® ION Mobility Technology