The wealth of information obtained through MS metabolomics and lipidomics analyses contributes significantly to our understanding of biological systems, disease mechanisms, and potential therapeutic targets. Applying new technologies to these efforts helps scientists and clinicians work more efficiently to gain insights faster. Advanced instrumentation strengthens capabilities and offers improved sensitivity, robustness, and speed, allowing for more accurate and comprehensive analysis of complex biological samples. With the aid of these instruments, researchers can identify and quantify a broader range of metabolites and lipids, leading to a deeper understanding of biochemical pathways and disease processes.