In the study of proteomics, until now, the sheer complexity of the proteome, with its variability and dynamic range, has dictated the need for specialized methods and compromises between discovery and quantification. Too often, lengthy research projects have resulted in long protein identification lists with ambiguous biological significance.
SCIEX delivers innovative tools that help proteomics researchers quickly find meaningful answers with confidence. With the launch of the ZenoTOF 7600 system, and its revolutionary Zeno trap and electron-activated dissociation (EAD), researchers can now routinely identify, quantify and characterize critical low-abundance proteins and their post-translational modifications, and unlock a new level of biological insight.
The power of the Zeno trap and EAD for data-dependent acquisition (DDA) approaches, as well as SWATH acquisition for data-independent acquisition (DIA) approaches, in high-quality quantitative MS/MS data, which leads to more insightful results in protein identification, labeled quantification and label-free quantification. The increased full-scan sensitivity and access to more diverse fragmentation mechanisms is also advantageous for the characterization of proteins, while the sensitivity of the SCIEX 7500 system for targeted MRM-based approaches means very low-abundance proteins can be readily quantified.