An introduction to accurate mass and Quadrupole-Time-of-Flight technology with SCIEX

Until recently, nominal mass triple quadrupole technology was considered the gold standard for quantitative assays. In contrast, high-resolution mass spectrometry was primarily used for qualitative, semi-quantitative, and non-targeted workflows, such as metabolite identification, screening, and X-Omics. However, advancements in technology, including faster scan speeds and improved ion optics, have expanded the capabilities of high-resolution spectrometry. Now, it can be effectively applied to both qualitative and quantitative workflows. The ZenoTOF 7600 system, with its high scan rates and enhanced duty cycle at the MS2 level, bridges the gap between these approaches, offering a greater return on investment by reducing data acquisition times and maintaining sensitivity without compromising data quality. This webinar series will focus on how to transition from the Triple Quad to a high-resolution environment for different applications.

SCIEX specialists to learn about:

Speaker: Jessica Smith, Market Development Manager Software EMEAI, SCIEX

Fundamentals of accurate mass

  • Theory behind accurate mass
  • How accurate mass works
  • Acquisition capabilities

Speaker: Heather Chassaing, Senior Accurate Mass Workflow Specialist, SCIEX

Advantages of HRMS for Quantitative Workflows 

  • Efficiency and Cost Savings: Discover how HRMS quantitation can significantly reduce time and expenses
  • Seamless Transition: Learn the steps to transition your established MRM assays to MRMHR with ease
  • Streamlined Processes: Explore methods to streamline the entire workflow from biomarker discovery to quantitation

Speaker: Tom Ruane, Accurate Mass Workflows Specialist, SCIEX

 Alternative Fragmentation Modes – EAD, CID and more

  • What are EAD & other alternative fragmentation modes and how to do they work?
  • What do EAD spectra look like for different molecule types?
  • Benefits of EAD and when to use it with or instead of CID

Speakers:

Jessica Smith, Market Development Manager Software EMEAI, SCIEX

Jessica joined SCIEX in 2021 as a technical marketing specialist; her responsibilities included managing projects throughout EMEAI and creating new technical marketing content. Her current role is Marketing Development Manager Software EMEAI, educating customers on the transition from Analyst software to SCIEX OS software.

Jessica also studied for a Ph.D. in materials chemistry for environmental applications.

Heather Chassaing, Senior Accurate Mass Workflow Specialist, SCIEX

Heather Chassaing has over 20 years of experience in analytical science, with a strong background in biochemistry. She has worked extensively in both the agrochemical and pharmaceutical industries, gaining comprehensive expertise in the research and development of drug entities, as well as the complexities of drug production. Heather is particularly passionate about structural elucidation and the application of Mass Spectrometry to these workflows.

Tom Ruane, Accurate Mass Workflows Specialist, SCIEX

Tom has been working for SCIEX since 2018, having worked at Phenomenex since leaving the University of Manchester in 2015. He currently helps SCIEXs customers across Nordic countries, UK and Ireland working in life science research and drug development. In particular he has an interest in accurate mass technologies.

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