Canned Calculation for SANTE Guideline 11312/2021v2- C20 Available for SCIEX OS Software

For research use only. Not for use in diagnostic procedures.

Issue Description

SCIEX provides pre-assembled calculation packages ('Canned Calculations') for use with processing methods created in SCIEX OS software for several common application workflows. These calculation packages can be used with SCIEX OS software version 2.1.6 and higher, depending on the used features, and contain the custom calculations and flagging rules needed to process data for a commonly-used application, such as the technical guidance for detecting pesticide residues in the European Union, SANTE 11312/2021v2.

This article provides information on the custom calculations required for processing data according to the guidance found in SANTE 11312/2021v2 – C20:
‘All targeted analytes must be injected in every batch of samples, at least at the level corresponding to the RL. Sufficient response at this level is required and should be checked to avoid false negatives.’

Resolution

The idea behind Canned Calculations for SCIEX OS software is to provide a ready-to-go, user friendly, data processing solution containing all the calculations and flagging rules that can be imported into a results table created in the Analytics workspace.
The calculations do provide a plug-and-play approach, but the resulting custom columns in the results table require some additional interpretation after applying the calculations. Each calculation in the package should be evaluated and adjusted to suit each lab's needs, they should apply their own insights when interpreting method guidelines, when identifying the samples used for the calculations, when presenting the results and when linking different calculations.

To avoid false negatives all targeted analytes must be injected in every batch of samples, at least at the level corresponding to the RL. SCIEX generated a set of calculations and flagging rules that provide custom columns which check sufficient response (defined as S/N>=10), and retention time (+- 0.1 minutes compared to STDs mean RT) in these samples. The example result table below shows custom columns, generated with the canned calculations in SCIEX OS v3.3.1 using a default data set, that is available when you are logged in on our website at this link in 'SCIEX OS Resources':
https://sciex.com/support/software-support/software-downloads



Requests to obtain the canned calculation package for SANTE 11312/2021v2 – C20 can be made by opening a case with SCIEXNow, indicating which software version is used and referencing this article.