Considerations when Changing the Default Source/Gas Parameters in Analyst® Software

For research use only. Not for use in diagnostic procedures.

Answer

The default source and gas parameters can be updated for acquisition methods created in Analyst® software so that subsequent new methods will reflect the new default values. Changing the default parameters will add new default parameter settings to acquisition methods created in Acquire mode and in Tune and Calibrate mode, which will impact manual and automatic optimization methods, as well as LCMS methods.

Before changing any of the default parameter values, do the following:

• Save and close all open methods and other windows in Analyst software.
• Take a screen shot of the current default values and save it as a backup.

The default parameter values are stored in the instrument parameter settings in the Configure mode. Navigate to the Tools menu, select Settings and then select Parameter settings. When the Parameter Settings Editor window appears, choose the desired scan category in the dropdown. Double-click on the source parameter and enter the desired value into the Access Default box. Click OK. After adjusting the desired source and gas parameter defaults, click OK on the Parameter Settings Editor window.

Do not change any other default parameters for the instrument – besides the source and gas settings – in the default parameters window. Use extreme caution when changing these values, and contact SCIEX technical support with any questions about changing any of the listed parameters. Even when changing a source parameter, its best to consult with the technical support team. 

Source values must be changed consistently across all scan categories of the same polarity. For example, if temperature is changed to 300° C, for Q1+ scan, also make sure to choose the same temperature for Q3+ and MS/MS+ scan modes. This is especially important when system performs automatic compound optimization and when different scan modes are used sequentially.