If Default Project Parameters Change, Are Existing Non-targeted Processing Methods Affected?

For research use only. Not for use in diagnostic procedures.

Answer

Data processing methods in SCIEX OS software contain several different quantitative and qualitative settings that are used when creating results tables. When a non-targeted method is created, the current project default parameters for peak integration are used, and these are saved to the processing method file (.qmethod).  If a non-targeted processing method contains targeted analytes as well, then the customized integration parameters for the targeted components will not be applied to the non-targeted peak integration.  If a user changes the project default parameters, then the new parameters will not impact an existing non-targeted method, and the original parameters are preserved.  Only newly created non-targeted methods will use updated integration parameters.