Date: | 07/07/2023 |
Categories: | Academia Omics , ProteinPilot Software |
For research use only. Not for use in diagnostic procedures.
Answer
When searching with ProteinPilot™ software 5.0, 5.0.1 and 5.0.3, an error occurs: Unhandled Exception: Out Of Memory Exception. This error results from the LCMS Reconstruct algorithm crashing while ProteinPilot software processes data sets with high MS1 scan speeds.
The workaround is to have the software use the old signal processing algorithm. This can be done by modifying the ProteinPilot.exe.config file located in the directory C:\Program Files\AB SCIEX\ProteinPilot. Open this file with Notepad and then make the following change:
1) Find the line <add key="RunLCMSReconstruct" value="true"></add> (see below)
2) Change it to: <add key="RunLCMSReconstruct" value="false"></add> (see below)
3) Save the file.
4) Restart the software and search the ProteinPilot software data set. Be sure to switch the config file back after searching the data file that was causing the crash. Typically, the LCMS Reconstruct algorithm is superior for general use.
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