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The method employs a simple liquid-liquid extraction sample preparation to separate bimatoprost from human plasma achieving a lower limit of quantitation of 0.5 pg/mL with %CV <3%.
Demonstrates an accurate mass spectrometry method for quantifying a selective Anaplastic Lymphoma Kinase (ALK) degrader and PROTAC, TL 13-12, and its inactive control, TL 13-22 in rat plasma.