Ensuring animal welfare and fairness in competitive sports
The detection of doping substances in animal sports can be challenging since the practice is likely as old as the sport itself. Despite the natural physical abilities of animals, the use of performance-enhancing substances in competitive sports remains prevalent. This illegal practice not only presents ethical issues related to the health and welfare of the animals, but also compromises the integrity of the sport. Controlling the presence of prohibited substances in animals is critical to protecting their health and ensuring fair competition.
SCIEX offers a variety of robust and comprehensive anti-doping workflows to detect and quantify trace levels of banned substances in animal biological matrices. Whether your laboratory conducts routine screening to uncover prohibited substances or requires accurate quantitation of drug exposure (identification of the parent drug and its metabolites), our LC-MS/MS technology delivers the required levels of specificity and sensitivity for your most challenging animal-doping analysis. Discover how our portfolio of LC-MS/MS instruments empowers animal-doping laboratories worldwide to confidently detect and quantify prohibited substances, and even enables retrospective analysis to identify new drugs.
Gene doping refers to the use of agents to trigger a cell’s production of performance-enhancing proteins. A common gene-doping practice in horse racing involves the use of therapeutic oligonucleotides—such as oligomers or polymers of nucleic acids and nucleic acid analogues—to artificially enhance the physical performance of racehorses. This practice is a rising concern in horse racing, and it poses a serious threat to the integrity of horse racing and equestrian sports. The need is urgent for robust and precise detection methods to identify gene doping in horses.
To meet this need, SCIEX offers reliable LC-MS/MS solutions for confident detection of gene-doping agents and their biomarkers.
Characterization and quantitation of phosporothioated (PS) oligonucleotides in horse plasma for gene doping control
The use of gene delivery technologies is a rising concern in sports, and particularly in horse racing. This technical note highlights the use of accurate mass spectrometry for the comprehensive characterization and accurate quantitation of a phosphorothioate (PS) moiety—a specific product ion of phosphorothioated oligonucleotides (PSOs)—as a marker for gene-doping detection in horse racing.
In recent years, the prevalence of performance-enhancing substances in animal sports, and particularly its use in horse racing, has become a growing concern. The use of these substances in animals to boost their physical performance can be harmful to both the health of the animal and the credibility of the sport, and for this reason, the ability to reliably detect and quantify performance-enhancing substances is crucial.
While analyzing these substances can be challenging due to the nature of the agents used for doping and their chemical diversity, LC-MS/MS provides the specificity and sensitivity required to detect trace levels of these substances from animal biological matrices. Discover how robust solutions from SCIEX can help you with your most challenging anti-doping workflows.
ZenoTOF 7600 system
The ZenoTOF 7600 system provides unique features that enhance MS/MS capabilities. It combines the power of the Zeno trap for improved MS/MS sensitivity with an alternative fragmentation technology—electron activated dissociation (EAD)—that provides unique fragments for drug and metabolite characterization.
X500R QTOF system
The X500R QTOF system is the most versatile and easy-to-use accurate mass instrument for routine drug screening. The system can be used for high-specificity, targeted quantitation and non-targeted screening from single sample sets in a high-throughput laboratory environment.
SCIEX OS software
SCIEX OS software is the all-in-one software solution for forensic toxicology screening that lets you acquire, process, analyze data and even generate reports in the same software environment. It enables streamlined data processing of challenging forensic data sets with integrated tools to increase confidence in your results.
Forensic HR-MS/MS spectral library 2.1
Confirm identification of commonly tested drugs and metabolites using the Forensic HR-MS/MS spectral library. With over 1,740 forensic drugs and metabolites commonly tested in forensic samples, this high-resolution library enables fast processing of targeted and non-targeted screening data for accurate compound identification from complex biological samples.
Forensic toxicology
Whether you need to comprehensively screen for drugs, confirm and quantify them, identify unknown substances or characterize new and emerging drugs, SCIEX has a solution that meets all your most demanding requirements.
Homeland security
Detecting trace levels of seized drugs, chemical warfare agents, explosives or illicit materials requires high throughput and sensitive instrumentation. SCIEX has an extensive portfolio of LC-MS/MS instrumentation that provides the evidence required by the forensic and security communities.
Cannabis and hemp potency testing
The diversity of cannabis and hemp products makes it hard to perform potency testing accurately. SCIEX provides sensitive, accurate and precise instrumentation capable of differentiating legalized hemp products from controlled cannabis. Forensic labs, where such use is permitted under local state/country law, can now test with the highest confidence.