Be ready for anything with quantitative and qualitative capabilities on the same instrument

X500R QTOF system reduces the complexity of HRMS

For the modern researcher who needs flexible and scalable workflows that deliver reliable, high-quality, accurate mass results with confidence, the X500R will quickly become your workhorse. Built specifically to balance robust performance with triple-quad-like quantitation, you can perform everything from untargeted analysis to broad screens, comprehensive profiling, and identification of unknowns, all on the same instrument.

With simple workflows, robust hardware, sensitivity, and precision, the X500R QTOF is the first high-resolution LC-MS/MS system designed for both characterization and quantitation. 

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With simple workflows, robust hardware, and end-to-end balanced performance, the X500R QTOF is the first high resolution LC-MS/MS system designed for routine testing to deliver exceptionally reliable results.

Take the complexity out of your data

Made for high throughput analyses, the X500R QTOF system offers triple-quad level quantification levels and accurate ion ratios with intuitive software to quickly turn data into groundbreaking discoveries.

  • Renowned SWATH data independent acquisition (DIA) enables comprehensive detection, so you won’t miss any critical MS/MS information for your application needs. 
  • SCIEX spectral libraries offer more compounds for more complete screening studies
  • Gain efficiency, see improved usability and achieve greater integrity with easy to learn and use SCIEX OS software

Key features

Stability over long runs

Six heater drones throughout the TOF path ensure that the system maintains mass accuracy even through longer runs.

Superior instrument uptime

Quick and easy QJet access enables fast and efficient maintenance, so your instrument is up and running virtually all the time.

Robust ionization in complex samples

Renowned ionization performance from the Turbo V ion source is now delivered with a high-resolution accurate mass analyzer.

Never compromise on performance

The N-optic design with 4mm orifice leading into the TOF accelerator tube delivers resolution without compromising sensitivity.   

Requires very little precious lab space

Occupies less lab space than any other HRMS on the market today (110x57x112cm).

Spectral libraries

Multiple libraries all benefit from mass defect filtering and covering myriad classes of compounds

Simplify the complexity of high resolution mass spec

Simple workflows, robust hardware, and balanced performance

Expand the potential of your laboratory and deliver comprehensive sample analysis. The X500R QTOF system is a high resolution accurate mass LC-MS/MS system designed for high throughput testing.

Featured applications powered by the X500R

Your workhorse in the laboratory

Accessible to experts and non-experts alike, with the flexibility to acquire and process quantitative and qualitative data simultaneously, all while fitting neatly on your benchtop, the X500R was designed to be robust and reliable for all your application needs. From comprehensive spectral libraries based on high-resolution MS data to leveraging data-independent analysis for screening many classes of compounds, the X500R will quickly become your most trusted LC-MS.

Detection and identification of extractables and leachables

Showcasing a comprehensive workflow for the complete identification of components using a unique E&L library covering 675 compounds

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Comprehensive DBS screen of 132 novel psychoactive substances

A fast and optimized dried blood spot sample extraction procedure was developed for the detection of 132 drugs

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Targeted metabolomics screen

Streamline your targeted workflows with a single injection and high-resolution, accurate mass metabolite spectral library

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See it all with SWATH acquisition

Ensure you have no missing data and future-proof your laboratory. The X500R QTOF system can handle your most complex matrices without compromise. SWATH acquisition is simple to deploy and uses ion ratios to confirm your positive unknown screening results.

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Software for simplicity

SCIEX OS software on the X500R QTOF system is highly intuitive, accelerating data collection and simplifying data processing for technicians of any skill level.

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Practical high-resolution workflow

Reduce backlogs and deliver results on time. The X500R incorporates Turbo V technology which enables your lab to see the key analytes in the most challenging of samples.

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Key features of the X500R system

Mass range TOF

Up to 40 kDa. Precursor ion selection: 5-2250 m/z.

Mass accuracy over time, external

Less than 2 ppm RMS over 12 hours of LC-MS

Ionization sources

Turbo V ion source with twin sprayer ESI probe and twin sprayer APCI probe

TOF-MS resolution and speed

≥ 42,000 (FWHM) measured on the (M+6H)6+ charge isotope cluster for bovine insulin at m/z 956

Maximize productivity with the complete solution

ExionLC AE system

The ExionLC AE system offers precise analytical flow LC seamlessly integrated with your favorite SCIEX MS system for reproducible and reliable assays, batch after batch.

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Spectral libraries

Dramatically enhance the quality of your analysis with high resolution and QTRAP system libraries.

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Screen 664 compounds in < 10 mins

Detect a comprehensive suite of familiar and novel psychoactive forensic analytes in whole blood or urine.

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