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- iMethod Application for Bisphenol Octylphenol and Nonylphenol for Cliquid Software
Status: Available
Bisphenol A (BPA) is widely used in high-production volume manufacturing of polycarbonate plastics and epoxy resins. Current studies evaluating the impact of BPA on health and the environment have not reported conclusive results. Octylphenol (OP) and nonylphenol (NP) are degradation products of alkylphenol ethoxylates, a family of nonionic surfactants widely used in consumer and institutional cleaning products. The estrogenic and toxic effects of OP and NP have been well-studied and reported.
By using ultra high performance Rapid Separation (RS) LC-MS/MS, BPA, OP and NP in water samples can be analyzed much more rapidly than using a labor intensive sample derivatization GC-MS method. This RSLC-MS/MS method has a significantly shorter run time of just 5 minutes compared to 25 minutes using GCMS technology, and uses a small particle size 2.2Āµm analytical column to provide robust and reproducible high throughput analysis.
Method filesĀ (ZIP)
Activity | Using an iMethodā¢ Application | Traditional Method Development |
---|---|---|
Complete Test Protocol Documentation | Included | WeeksāMonths |
Sample Prep Techniques | Included, with examples and references | WeeksāMonths |
Optimized MS/MS Acquisition Parameters | Included | WeeksāMonths |
LC Instrument Parameters with Retention Times | Included | DaysāWeeks |
Integration (Quantitation) Parameters | Included | Days |
Reporting Templates | Included | Days |
LC/MS/MS Library Spectra | May be included. Stand-alone libraries are also available. | WeeksāMonths |
Staff TrainingĀ ā Software | Simple CliquidĀ®Ā Software interface, no additional training | Traditional MS Software and review procedures ā Days |
Method Validation | Weeks. Validation templates and support available | WeeksāMonths |
Complete Test Development and Deployment | Weeks | 6ā12 months |