iMethodā„¢ Application for Bisphenol, Octylphenol and Nonylphenol for CliquidĀ® Software (Partner Contributed)

For research use only. Not for use in diagnostic procedures.



iMethod Application for Bisphenol Octylphenol and Nonylphenol for Cliquid Software

Overview

Bisphenol A (BPA) is widely used in high-production volume manufacturing of polycarbonate plastics and epoxy resins. Current studies evaluating the impact of BPA on health and the environment have not reported conclusive results. Octylphenol (OP) and nonylphenol (NP) are degradation products of alkylphenol ethoxylates, a family of nonionic surfactants widely used in consumer and institutional cleaning products. The estrogenic and toxic effects of OP and NP have been well-studied and reported.

By using ultra high performance Rapid Separation (RS) LC-MS/MS, BPA, OP and NP in water samples can be analyzed much more rapidly than using a labor intensive sample derivatization GC-MS method. This RSLC-MS/MS method has a significantly shorter run time of just 5 minutes compared to 25 minutes using GCMS technology, and uses a small particle size 2.2Āµm analytical column to provide robust and reproducible high throughput analysis.

Method filesĀ (ZIP)

ActivityUsing an iMethodā„¢ ApplicationTraditional Method Development
Complete Test Protocol DocumentationIncludedWeeksā€“Months
Sample Prep TechniquesIncluded, with examples and referencesWeeksā€“Months
Optimized MS/MS Acquisition ParametersIncludedWeeksā€“Months
LC Instrument Parameters with Retention TimesIncludedDaysā€“Weeks
Integration (Quantitation) ParametersIncludedDays
Reporting TemplatesIncludedDays
LC/MS/MS Library SpectraMay be included. Stand-alone libraries are also available.Weeksā€“Months
Staff TrainingĀ ā€“ SoftwareSimple CliquidĀ®Ā Software interface, no additional trainingTraditional MS Software and review procedures ā€“ Days
Method ValidationWeeks. Validation templates and support availableWeeksā€“Months
Complete Test Development and DeploymentWeeks6ā€“12 months