The ideal choice for any workflow

NanoLC 400: A low flow LC-MS solution

The NanoLC 400 series enables a full range of analytical workflows that drive the identification of novel biomarkers or the quantification of small molecules and biologics to advance precision medicine research.

This front-end system consistently delivers accurate retention times, reproducible injection down to 200 nL and covers a broad range of flow rates.

Explore this currently available system

M5 MicroLC system

The M5 MicroLC system is the perfect balance of sensitivity and robustness, giving you the potential to optimize your crucial workflows, today and into the future.

Learn more

Key features of NanoLC 400 series


NanoLC 415 for basic direct-to-column or trap-and-elute workflows
NanoLC 425 for more advanced 2D workflows

Column oven

Compatible with the OptiFlow Turbo V column oven. Column oven provides excellent retention time reproducibility by ensuring consistent column temperature

Flow rates

Multiple flow rate options with user-interchangeable plug-and-play flow modules to switch between nanoflow (100 nl/min - 1 µl/min) and microflow (1 - 10, or 5 -50 µl/min)

Flow accuracy

SCIEX's innovative multifluidic flow control technology, for consistent, accurate retention times without flow-splitting


Integrated and controlled with SCIEX Analyst software