AB Sciex is doing business as SCIEX. © 2010-2019 AB Sciex. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB SCIEX™ is being used under license. Beckman Coulter® is being used under license. Product(s) may not be available in all countries. For information on availability, please contact your local representative. For research use only. Not for use in diagnostic procedures.
The TripleTOF 5600+ System combines the best-in-class front end of SCIEX Triple Quad technology with the Accelerator TOF Analyzer, to deliver nominal mass and accurate mass benefits in a single platform.
This proven workhorse uniquely integrates comprehensive, qualitative exploration, rapid profiling, and high-resolution quantitation workflows, providing high performance and versatility for pharmaceutical development, omics research and any challenging unknown compound analysis.
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The TripleTOF 5600+ System is the next generation in quadrupole TOF technology. Combining the best-in-class front end of the Triple Quad 5500 System with the Accelerator TOF Analyzer, this instrument adds high resolution at the speed and sensitivity needed to give %CVs and limits of quantitation (LOQ) equivalent to those of high-end triple quadrupoles.
Now for the first time, pharmaceutical, academic, and analytical testing scientists can integrate comprehensive, qualitative exploration, rapid profiling, and high-resolution quantitation of low-abundance analytes in very complex matrices – all on a single platform.
|MS/MSALL with SWATH® Acquisition||Quantitative MS/MS data that rivals triple quadrupole sensitivity and precision for every component in complex samples. And... a complete digital archive of all precursor and product ions in a sample, for unlimited retrospective interrogation without the need to re-acquire data.
|21 CFR 11 Compliance Module||Software tools that support digital record-keeping and electronic signatures, enabling the use of TripleTOF® Technology in a regulated environment.|
|Highest sensitivity with QJet Ion Guide and Accelerator TOF Analyzer||Low-abundance analytes easily discovered, identified, and quantified|
|SmartSpeed 100Hz Acquisition||The fastest, high-resolution system that generates more high-quality information from every sample, even when using fast chromatography|
|EasyMass Accuracy||Achieves high mass-accuracy without continuous recalibration, making it the easiest-to-use system for routine accurate mass.|
|One-touch productivity software||Increases productivity by facilitating powerful workflows to create information out of data|
|High resolution at up to 100 spectra per second||Definitive identification at high speed even when using fast chromatography|
|Magnetic levitation (MagLev) turbo pumps||New level of reliability for reduced cost of ownership and virtually silent running for a better lab environment.|
|Explore Workflow||Explore complex samples in greater depth: Select up to 50 precursors per second – and generate high resolution and high mass-accuracy MS/MS data using powerful IDA (Information-Dependent Acquisition) algorithms and high-resolution, accurate-mass MS and MS/MS.|
||Profile samples for quant and qual in a single run: Quantify virtually every compound in the sample with high-resolution MS quantification and fast chromatography; confirm compound identity with high-resolution, accurate-mass MS/MS; and then mine the data for the information you need.|
|Quantify Workflow||Quantify analytes with high-resolution MRM transitions for highest specificity and confidence: Obtain high resolution at high and low masses in the same spectrum for high-resolution, MRM-like quantification. The LOQ's and dynamic range are equivalent to high-performance triple quadrupoles. Cycle times are as low as 10 msec and generate superior peak definition, even with fast LC separations. Quantification requires little optimization, and you can choose multiple fragments per precursor from the acquired full-scan MS/MS data.|
|Separation of Ephedrine and Pseudoephedrine Isomers Using SCIEX SelexION Differential Mobility Technology||02/15/2019|
|Digitizing the Proteomes From Big Tissue Biobanks||12/26/2018|
|Resolution of Ether and Diacyl-Linked Phospholipids by Differential ION Mobility Spectrometry (DMS)||11/19/2018|
|Metabolomics Online Symposium Cajka||10/16/2018|
|Differential Mobility Spectrometry Resolves Chlorine- and Acetate- Adducts of Phosphatidylcholine (PC)||10/09/2018|
|Enabling Systems Biology Driven Proteome Wide Quantitation of Mycobacterium Tuberculosis using SWATH Acquisition||06/28/2018|
|BioPharmaView Software 3.0 Product Bulletin||05/01/2018|
|Simplifying the Use of Ion Libraries during Data Processing of SWATH Acquisiton Proteomics Data||04/10/2018|
|Triple TOF 5600+ Declaration of Conformance||03/12/2018|
|Ion Source Tests, Specifications, and Data Log||03/10/2018|
|Multi-Omics Analysis of Human Embryonic Stem Cell Neural Differentiation||12/22/2017|
|User Guide: TripleTOF 5600/5600+ Instruments System User Guide||12/20/2017|
|User Guide: TripleTOF 5600/5600+ Instruments System User Guide (FR)||12/20/2017|
|User Guide: TripleTOF 5600/5600+ Instruments System User Guide (DE)||12/20/2017|
|User Guide: TripleTOF 5600/5600+ Instruments System User Guide (IT)||12/20/2017|
|User Guide: TripleTOF 5600/5600+ System Qualified Maintenance Person Guide||12/20/2017|
|User Guide: TripleTOF 5600/5600+ System Qualified Maintenance Person Guide (DE)||12/20/2017|
|User Guide: TripleTOF 5600/5600+ System Qualified Maintenance Person Guide (FR)||12/20/2017|
|User Guide: TripleTOF 5600/5600+ System Qualified Maintenance Person Guide (IT)||12/20/2017|
|User Guide: DuoSpray Ion Source for TripleTOF Systems Operator Guide (FR)||12/20/2017|
|User Guide: DuoSpray Ion Source for TripleTOF Systems Operator Guide (IT)||12/20/2017|
|User Guide: Turbo V Ion Source Operator Guide (ES)||12/20/2017|
|User Guide: Turbo V Ion Source Operator Guide (PL)||12/20/2017|
|User Guide: Turbo V Ion Source Operator Guide (PT)||12/20/2017|
|Turbo V Ion Source Operator Guide (RU)||12/20/2017|
|Turbo V Ion Source Operator Guide (ZH)||12/20/2017|
|Turbo V Ion Source Operator Guide (JA)||12/20/2017|
|User Guide: Turbo V Ion Source Operator Guide (IT)||12/20/2017|
|User Guide: Turbo V Ion Source Operator Guide (FR)||12/20/2017|
|Automated HIgh Throughput Trypsin Digests for HIghly Reproducible Peptide Map Analysis||12/20/2017|
|User Guide: TripleTOF 5600/5600+ System Qualified Maintenance Person Guide (ES)||12/20/2017|
|User Guide: TripleTOF 5600/5600+ Instruments System User Guide (ES)||12/20/2017|
|Expanding Suspect Screenig and Non-Targeted Identification||12/20/2017|
|Dont miss Synthetic Drug Present in Sample||12/20/2017|
|Improved Data Quality Using Variable Q1 Window Widths in SWATH Acquisition||12/11/2017|
|Ultra-sensitive Host Cell Protein Dection using CESI-MS with SWATH Acquisition||12/10/2017|
|Over 17K Compounds Available-X500R and Spectral Libraries||12/10/2017|
|Extending Metabolome Coverage-untargeted Metabolomic Workflows||12/05/2017|
|SWATH Acquisition Enables the Ultra-Fast and Accurate Determination of Novel Synthetic Opioids||11/30/2017|
|DuoSpray Ion Source for TripleTOF Systems Operator Guide (EN)||10/10/2017|
|DuoSpray Ion Source for TripleTOF Systems Operator Guide (DE)||10/10/2017|
|Turbo V Ion Source Operator Guide (DE)||10/10/2017|
|Turbo V Ion Source Operator Guide (EN)||10/10/2017|
|TripleTOF 5600+ Site Planning Guide (EN)||10/10/2017|
|TripleTOF 5600+ Site Planning Guide (DE)||10/10/2017|
|TripleTOF 5600+ Site Planning Guide (ES)||10/10/2017|
|TripleTOF 5600+ Site Planning Guide (FR)||10/10/2017|
|TripleTOF 5600+ Site Planning Guide (IT)||10/10/2017|
|User Guide: SelexION and SelexION+ Technology Troubleshooting||09/30/2017|
|Quantification of Large Oligonucleotides using High Resolution MS/MS on the TripleTOF® 5600 System||09/15/2017|
|CloudConnect Auto Uploader||09/12/2017|
|Solutions for Biotherapeutic Characterization||08/01/2017|
|High Throughput, Data Independent Acquisition for Qualitative and Quantitative Shotgun Lipidomics||06/20/2017|
|Using Multi-Omics Analysis to Study EMT Model of Prostate Cancer||06/04/2017|
|Proteome-wide Profiling of Drug Dose-Response in Prostate Cancer Cell Lines by Microflow SWATH Acquisition||06/04/2017|
|Dev of Hi-Throughput Proteomics Pipeline-SWATH Profiling Biochemical Individuality||06/04/2017|
|SCIEX Quantitation and Metabolism Solutions Brochure||05/26/2017|
|MetabolitePilot Software 2.0||05/04/2017|
|Impact of High-Resolution MRM Analysis on Complex Proteomes||05/02/2017|
|SWATH AAFS Poster||04/04/2017|
|Investigating Biological Variation of Liver Enzymes in Human Hepatocytes using SWATH Acquisition||02/15/2017|
|MarkerView Software 1.3 New Features||12/15/2016|
|M3 MicroLC for TripleTOF-Test and Data Log||12/10/2016|
|M3 MicroLC-TE for TripleTOF-Test and Data Log||12/10/2016|
|Analysis of Intact MUPs (Major Urinary Proteins) from Mice by CESI-MS||11/09/2016|
|Why Compromise-The Benefit of High-Resolution Quantitative Analysis||09/15/2016|
|NanoLC Systems for TripleTOF systems Test and Data Log||09/01/2016|
|Combination of Isobaric Tagging Reagents and Cysteinyl Peptide Enrichment for In-Depth Quantification||08/31/2016|
|Comprehensive Quantitative Phosphoproteomic Approach using MS/MSALL with SWATH Acquisition||08/31/2016|
|PCT-SWATH for Protein Quantitation-Tissue to Peptids in 4 Hours||07/01/2016|
|Non-Targeted Metabolic Profiling of Human Urine Samples||05/13/2016|
|UHPLC-ESI-QTOF-MS/MS based Lipidomics by Data-independent Acquisition||05/11/2016|
|The Lipidyzer- a new platform for quantitative Lipidomics||05/11/2016|
|CESI-MS a technique for the characterization and analysis of both intact and digested biopharmaceuticals||05/11/2016|
|industrializing omics-SCIEX Life Science Research towards Precision Medicine||05/01/2016|
|User Guide: TripleTOF Systems Electromagnetic Environment Information||04/20/2016|
|Understanding Complex Lipid Metabolism through Quantitative Lipidomics||03/15/2016|
|SCIEX Defined Major Repairs||01/10/2016|
|Comprehensive Characterization of Low Molecular Weight Heparins Using High Resolution Mass Spectrometry||12/15/2015|
|MS/MS-ALL with SWATH Acquisition||11/10/2015|
|Using MS/MS with SWATH Acquisition for Forensic Drugs Screening with SCIEX TripleTOF 4600/5600+ LC-MS/MS System||10/08/2015|
|Eksigent MicroLC 200/200 Plus Systems||10/05/2015|
|User Guide: NanoSpray Ion Source Operator Guide||08/31/2015|
|Automating Protein Digestion for Reproducible Proteomics||08/03/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide||05/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide (DE)||05/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide (IT)||05/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide (FR)||05/31/2015|
|SelexION Technology for TripleTOF Systems User Guide (ES)||05/31/2015|
|Investigating Relationship btwn Biological Variability and Biomarker Discovery by SWATH MS||05/21/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide||03/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide (DE)||03/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide (FR)||03/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide (IT)||03/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide (ES)||03/31/2015|
|Spectral Libraries for Food Analysis - Antibiotics||03/05/2015|
|Spectral Libraries for Food Analysis - Pesticides||03/05/2015|
|Metabolomic Profiling of Accurate Mass LC-MS/MS Data to Identify Unexpected Environmental Pollutants||01/01/2015|
|Accurate Mass Screening Workflows for the Analysis of Novel Psychoactive Substances||01/01/2015|
|Optimizing Chromatography and High Resolution TOF-MS for ADC DAR Characterization||06/15/2014|
|Impact of novel MS/MSALL acquisition and processing techniques on forensic toxicological screening||06/15/2014|
|User Guide: Calibrant Delivery System Operator Guide||06/01/2014|
|User Guide: Calibrant Delivery System Operator Guide (DE)||06/01/2014|
|User Guide: Calibrant Delivery System Operator Guide (FR)||06/01/2014|
|User Guide: Calibrant Delivery System Operator Guide (IT)||06/01/2014|
|User Guide: NanoSpray Ion Source Operator Guide (IT)||06/01/2014|
|User Guide: NanoSpray Ion Source Operator Guide (DE)||06/01/2014|
|User Guide: NanoSpray Ion Source Operator Guide (FR)||06/01/2014|
|Accurate Mass Screening Workflows for the Analysis of Novel Psychoactive Substances||03/01/2014|
|Are Pork Extracts Present in My Gummy Bears? Gelatin Speciation by LC-MS/MS||01/01/2014|
|Rapid Characterization of Naphthenic Acids Using High Resolution Accurate Mass MS and MS/MS with SelexION™ Differential Mobility Separation||01/01/2014|
|Instrument Front-End Cleaning Procedure Manual||10/01/2013|
|Rapid and Unbiased Quantitation of Host Cell Protein Contaminants in Biologics by MSMS of All Using a TripleTOF Mass Spectrometer||09/24/2013|
|Drug Screening Workflows using the TripleTOF 5600 System Advantages Compared to LC MS and LC TOF||09/13/2013|
|Advancing your Forensic Toxicology Analyses; Adopting the Latest in Mass Spectrometry Innovations||07/01/2013|
|Advances in Accurate Mass Spectrometry with the TripleTOF 5600 System||06/13/2013|
|Master Your Data to Get to the Answer, View Results with Ease and Confidence Using TripleTOF Technology and MasterView Software to Identify and Quantify Food Residues||04/01/2013|
|Simultaneous Quantitative Peptide Mapping and Host Cell Protein Detection||01/01/2013|
|Master Your Data to Get to the Answer, View Results with Ease and Confidence||01/01/2013|
|Master Your Data to Get to the Answer, View Results with Ease and Confidence (targeted)||01/01/2013|
|NanoLC Ultra System for TripleTOF 5600, QTRAP 5500 and 4000 QTRAP||03/05/2012|
|Profiling of Botanical Samples to Identify Unknown Chemical Contaminants and the Authenticity of Natural Ingredients Using High Resolution and Accurate Mass MS/MS||03/01/2012|
|High Reproducibility Targeted Quantitation at Highest Multiplexing||02/01/2012|
|Biomarker and Omics Solutions for Metabolomics||02/01/2012|
|Increasing the Multiplexing of High Resolution Targeted Peptide Quantification Assays||01/01/2012|
|Authenticity Assessment of Fruit Juices using LC-MS/MS and Metabolomic Data Processing||01/01/2012|
|Fast and Selective Quantification of Opiates in Urine using LDTD-TripleTOF® 5600 System||01/01/2012|
|ImpurityPilot Software 1.0 Beta||08/01/2011|
|Using PeakView Software with the XIC Manager for Screening and Identification with High Confidence based on High Resolution and Accurate Mass LC-MS/MS||04/02/2011|
|Targeted and Non-Targeted Screening for Drugs with High Confidence based on High Resolution and Accurate Mass LC-MS/MS||03/01/2011|
|Broader Coverage and Automatic Mass Calibration Using the TripleTOF® 5600 System with DuoSpray™ Ion Source||03/01/2011|
|MALDI Imaging of an Italian Banknote||03/01/2011|
|LC-MS/MS Based Strategy for the Non-Targeted Screening of an Unlimited Number of Contaminants in Food Using the SCIEX TripleTOF® 5600 System and Advanced Software Tools||03/01/2011|
|ProteinPilot™ Descriptive Statistics Template||03/01/2011|
|Brochure: Drug Discovery and Development Solutions||01/01/2011|
|Analysis of Polycyclic Aromatic Hydrocarbons (PAH), Alkylated Derivatives, and Photo-degradation Products in Environmental and Food Samples using LC-FLD-MS/MS with QTRAP Technology||01/01/2011|
|LC-MS/MS Solutions for Lipidomics - For Discovery and Targeted Lipidomics||01/01/2011|
|Molecular Characterization and Quantitation of Lipids with High Resolution Accurate Mass Tandem MS Techniques||01/01/2011|
|Targeted and Non-Targeted Screening for Drugs with High Confidence based on High Resolution and Accurate Mass LC-MS/MS||01/01/2011|
|Role of Sciex Mass Spectrometers in Ginseng R & D||01/01/2011|
|Scientist Respond to the Sciex Triple TOF 5600 System||07/19/2010|
|AB SCIEX Launches Groundbreaking Mass Spectrometry System||05/24/2010|
|Simultaneous Peptide Quantitation and Identification using High-Resolution MS: Profile Workflow on the SCIEX TripleTOF® 5600 System||03/05/2010|
|Breakthrough Productivity for ADME Studies with the New SCIEX TripleTOF® 5600 System||03/05/2010|
|Target and Non-Target Screening for Pesticide Residues in Food Samples using the SCIEX TripleTOF® 5600 System||03/05/2010|
|Metabolomic Profiling of Accurate Mass LC-MS/MS Data to Identify Unexpected Environmental Pollutants||02/01/2010|
|User Guide: NanoSpray Head and Emitter Tip Assembly Quick Start Guide|
|Simplifying the Use of Ion Libraries During Data Processing of SWATH Acquisition Proteomics Data|
|Multi-Omics analysis of Human Embryonic Stem Cell|
With optimized ion production, focusing, reflection and detection, the TripleTOF 5600+ System will help you dig deeper into complex samples.
Get more out of every sample with an additional dimension of separation with SelexION® Differential Ion Mobility Technology.
Efficient ion production while limiting contamination for maximized robustness, reliability and uptime.
Variable window capabilities allow for a large number of Q1 isolation windows at user controlled widths, up to 200 per cycle to achieve better specificity, even in complex samples.
Compatible with advanced front-end separation strategies including high-flow, microflow and nanoflow, and capillary electrophoresis spray ionization (CESI).
|Mass Range TOF||40 kDa|
|Mass Selection Range Q1||5 – 1250 m/z|
|TOF-MS Mass Resolution and Acquisition Speed||≥35,000 (FWHM) at 956 m/z, using 50 ms accumulation time|
|TOF-MS/MS Mass Resolution and Acquisition Speed||≥25,000 (FWHM) at 195 m/z, and ≥18,000 (FWHM) at 86 m/z, using 50 ms accumulation time|
|Detector Type||4-channel MCP detector with TDC signal processing for extended dynamic range|
|Flexible Data Acquisition Workflows|| TOF-MS
Information dependent acquisition (IDA) MS/MS
Data Independent SWATH® Acquisition with fixed or variable Q1 isolation windows
Targeted MRMHR workflow
|Ionization Sources||IonDrive™ Turbo V, DuoSpray™ source, each with TurboIonSpray® or Atmospheric-pressure chemical ionization (APCI) probes available; NanoSpray®III source, Digital PicoView NanoSource|
|Orthogonal Front End Separation Compatibility||Compatible with advanced front-end separation strategies including high-flow, microflow and nanoflow chromatography, capillary electrophoresis spray ionization (CESI), or using SelexION® differential ion mobility|
|Variable Window SWATH® Acquisition||Data-Independent SWATH® Acquisition with variable window capabilities, allows for a large number of Q1 isolation windows at user controlled widths, up to 200 per cycle to achieve better specificity, even in complex samples. Read More|
|Data File Portability||Condensed data file sizes simplify and streamline data storage and portability for sharing with colleagues, without losses in data quality, completeness or security|
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