June 17, 2021
Framingham, MA — SCIEX, a global leader in life science analytical technologies, presents the ZenoTOF 7600 system, a new accurate mass LC-MS/MS instrument. The new system enables scientists to identify, characterize and quantify molecules better than ever before by generating data that has been previously unattainable. This breakthrough will solve real analytical challenges and help advance the development of new precision diagnostics and biotherapeutics.
The ZenoTOF 7600 system includes the proprietary Zeno trap and electron activated dissociation (EAD) fragmentation for the first time in a commercial instrument. Zeno trap pulsing overcomes the traditional duty cycle challenges of orthogonal TOF technology, delivering up to 20x the sensitivity and enabling the routine detection of important low-abundant molecules. In combination, tuneable EAD fragmentation ensures novel structural information can be extracted and quantified from diverse compound types – a capability that is not possible by using high resolution alone.
Extraordinary sensitivity in combination with EAD fragmentation will push new boundaries in biomarker discovery and biopharmaceutical therapies
To advance the detection and treatment of disease, it is critical to understand how thousands of proteins, lipids and metabolites in the body are regulated and modified. Biomarkers, the molecules that change when we are ill, are used by doctors as the “canary in the coal mine” warning system. So far, scientists have only scratched the surface in biomarker discovery. The ZenoTOF 7600 system will help scientists uncover more and better biomarkers, bringing us closer to true precision medicine where the right drug is given to the right patient at the right time.
Compared to previous systems, the ZenoTOF 7600 system can quantify up to 40% more proteins and analyze samples 5x faster for large biobank studies. In addition, EAD fragmentation brings new capabilities to understand how the proteins are post-translationally modified – an important but challenging area in biomarker research.
The ZenoTOF 7600 system is transformational for lipidomics and can fully characterize an individual lipid from a single spectrum using EAD fragmentation. This will enable the discovery of novel lipid markers for cancer and inflammatory disease, precisely identifying and quantifying individual species that has been previously impossible.
To bring life-saving next-generation biopharmaceutical therapies to market quickly and safely, critical quality attributes must be rapidly and comprehensively analyzed. For the first time, EAD fragmentation allows biopharmaceutical scientists to precisely detect and quantify protein glycosylation patterns and differentiate isomeric amino acids. Both are critical to ensuring that therapies are safe and do not produce adverse reactions.
To learn more about the ZenoTOF 7600 system, visit here.
SCIEX delivers solutions for the precision detection and quantification of molecules, empowering our customers to protect and advance the wellness and safety of all. We have led the field of mass spectrometry for 50 years. From the launch of the first ever commercially successful triple quadrupole in 1981, we have developed groundbreaking technologies and solutions that influence life-changing research and outcomes.
Today, as part of the Danaher (NYSE: DHR) family of global life science and technology innovators, we continue to pioneer robust solutions in mass spectrometry and capillary electrophoresis. Our customers are able to quickly respond to environmental hazards, better understand biomarkers relevant to disease, improve patient care in the clinic, bring relevant drugs to market faster and keep food healthier and safer.
That’s why thousands of life science experts around the world choose SCIEX to get the answers they can trust to better inform critical decisions that positively impact lives.
For more information, visit sciex.com.
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