Doping detection in human samples

Rapid identification and quantitation of performance-enhancing stimulants in human urine using high-resolution mass spectrometry

The use of accurate mass spectrometry combined with data-independent approaches provides comprehensive and high-quality datasets for the identification and quantitation of performance-enhancing substances. Here, a comprehensive workflow is shown that combines the use of the X500R QTOF system with a fast sample preparation procedure to provide sensitive detection of a structurally diverse panel of stimulants in human urine.

Rapid detection of growth hormone-releasing peptides in dried blood spots: a proof-of-concept workflow for anti-doping analysis

Growth hormone-releasing peptides have recently received considerable attention in sports drug testing and are included in the World Anti-Doping Agency (WADA) Prohibited List. Discover a novel workflow that uses a rapid sample extraction procedure and a highly selective MS/MS acquisition method to enable sensitive detection of ipamorelin from dried blood spots with the X500R QTOF system.

Rapid screening of 65 common drugs and drug metabolites in urine and blood using high-resolution mass spectrometry

The ability to screen for drugs and their metabolites in the blood and urine of athletes is paramount for anti-doping laboratories to meet drug testing requirements. See how a comprehensive drug screening workflow using the X500R QTOF system enabled the rapid detection, identification and quantitation of 65 drugs and drug metabolites from urine and blood samples.

Implementing quantitative drug screening for workplace testing using accurate mass spectrometry

Learn about a rapid and comprehensive drug screening workflow that was developed for the analysis of urine samples using targeted acquisition of accurate mass spectra with the X500R QTOF system. This robust screening method enabled identification and quantitation of multiple drugs present in authentic urine samples.

Rapid detection and identification of 105 performance-enhancing substances in animal-derived foods (ADF)

In this technical note, a comprehensive screening method for the analysis of 105 common performance-enhancing substances in animal-derived foods was developed. Using the SCIEX QTRAP 4500 system, multiple reaction monitoring (MRM)-trigged enhanced product ion (EPI) scans allowed for simultaneous quantitation and confirmation using library searching.

High-sensitivity detection of forensic drug panel in human whole blood

The SCIEX 7500 system is a robust quantitative platform with exceptional performance in speed, linear dynamic range and sensitivity. Discover how an optimized method was used with this system for the accurate quantitation of a panel of 49 drugs in human whole blood with lower limits of quantitation in the sub-ng/mL to pg/mL range. The method was shown to maximize sensitivity while retaining the required levels of accuracy and performance.

High-sensitivity drug analysis using dried blood spots

There is increasing interest in using dried blood spots for toxicology applications, such as drug monitoring. Here, the SCIEX 7500 system was used to quantify a panel of 24 drugs and metabolites in dried blood spots. The extraction method was optimized to maximize the analyte extraction recovery across the broad panel. Lower limits of quantitation ranging from 5 to 250 pg/mL were obtained with the required levels of accuracy and performance. The SCIEX 7500 system was shown to have the sensitivity and robustness required for the suite of drugs targeted in this study.

Leveraging sensitivity improvements for low-level detection of drugs, metabolites, and endogenous hormones in complex biological matrices

The technological innovations included in the SCIEX 7500 system can be leveraged to improve the sensitivity and overall quantitation performance of a number of challenging forensic and clinical workflows. See how using the SCIEX 7500 system enabled improvements in both lower limits of detection and quantitation, which provided the ability to routinely and robustly detect ultra-low levels of analytes extracted from challenging biological matrices