Empowering laboratories for doping control sample analysis
The detection of doping, or performance-enhancing substances, in human samples is critical for leveling the playing field among athletes and protecting the integrity of competitive sports. Global standards for anti-doping policies and guidelines designed to deter the use of these substances are regulated by the World Anti-Doping Agency (WADA) and supported by both sports and governmental authorities.
Every year, WADA sets new analytical guidelines for drug testing methods and provides recommendations for implementing effective testing protocols in anti-doping laboratories. When it comes to putting these protocols into practice and identifying prohibited substances in biological samples, anti-doping laboratories require state-of-the-art instrumentation to confidently perform screening-to-confirmation workflows.
Why choose SCIEX LC-MS/MS instruments for doping detection?
SCIEX offers a diverse portfolio of LC-MS/MS instruments that are designed to meet the unique needs of anti-doping laboratories and address both initial testing and confirmation workflows. Whether your objective is untargeted screening for emerging threats or precise quantitation of known prohibited substances, our LC-MS/MS technology delivers unparalleled identification confidence and quantitation performance for your most demanding workflows.
Discover how our latest LC-MS/MS instruments and innovative solutions empower your laboratory to reliably screen, identify and quantify prohibited substances in human samples. Our accurate mass platforms provide additional confidence when screening for doping agents by reliably obtaining comprehensive MS/MS spectral fragment information from biological samples that can be used for identification, confirmation and library matching. In addition, our nominal mass instruments deliver high levels of performance for quantitative workflows, allowing accurate and sensitive detection of doping agents in the most challenging biological matrices. With the confidence enabled by our mass spectrometry systems, your laboratory can become a key supporter of fair competition for athletes across the globe.
Robust and comprehensive accurate mass spectrometry solutions to detect current emerging doping substances
Our screening-to-confirmation workflows harness the power of accurate mass spectrometry to efficiently and confidently perform high-throughput screening of large sets of prohibited substances. Whether your laboratory is looking to implement new screening workflows for known and emerging performance-enhancing drugs or develop characterization methods to stay ahead of future banned substances, our systems offer a variety of scanning workflows.
SCIEX instruments can perform sensitive and fast MS and MS/MS scanning experiments to screen and characterize every detectable component in a sample with high levels of selectivity and sensitivity, ensuring that you never miss the presence of a prohibited substance in your precious biological samples. Moreover, our accurate mass spectrometry platforms enable retrospective analysis of previously acquired datasets, allowing you to uncover the presence of newly emerged doping substances.
Rapid identification and quantitation of performance-enhancing stimulants in human urine using high-resolution mass spectrometry
The use of accurate mass spectrometry combined with data-independent approaches provides comprehensive and high-quality datasets for the identification and quantitation of performance-enhancing substances. Here, a comprehensive workflow is shown that combines the use of the X500R QTOF system with a fast sample preparation procedure to provide sensitive detection of a structurally diverse panel of stimulants in human urine.
Rapid detection of growth hormone-releasing peptides in dried blood spots: a proof-of-concept workflow for anti-doping analysis
Growth hormone-releasing peptides have recently received considerable attention in sports drug testing and are included in the World Anti-Doping Agency (WADA) Prohibited List. Discover a novel workflow that uses a rapid sample extraction procedure and a highly selective MS/MS acquisition method to enable sensitive detection of ipamorelin from dried blood spots with the X500R QTOF system.
Rapid screening of 65 common drugs and drug metabolites in urine and blood using high-resolution mass spectrometry
The ability to screen for drugs and their metabolites in the blood and urine of athletes is paramount for anti-doping laboratories to meet drug testing requirements. See how a comprehensive drug screening workflow using the X500R QTOF system enabled the rapid detection, identification and quantitation of 65 drugs and drug metabolites from urine and blood samples.
Implementing quantitative drug screening for workplace testing using accurate mass spectrometry
Learn about a rapid and comprehensive drug screening workflow that was developed for the analysis of urine samples using targeted acquisition of accurate mass spectra with the X500R QTOF system. This robust screening method enabled identification and quantitation of multiple drugs present in authentic urine samples.
Rapid detection and identification of 105 performance-enhancing substances in animal-derived foods (ADF)
In this technical note, a comprehensive screening method for the analysis of 105 common performance-enhancing substances in animal-derived foods was developed. Using the SCIEX QTRAP 4500 system, multiple reaction monitoring (MRM)-trigged enhanced product ion (EPI) scans allowed for simultaneous quantitation and confirmation using library searching.
ZenoTOF 7600 system
The ZenoTOF 7600 system provides unique features that enhance MS/MS capabilities. It combines the power of the Zeno trap for improved MS/MS sensitivity with electron activated dissociation (EAD), which is an alternative fragmentation technology that provides unique fragments for drug and metabolite characterization.
X500R QTOF system
The X500R QTOF system is a versatile and easy-to-use accurate mass instrument for routine drug screening. The system enables high specificity, targeted quantitation and non-targeted screening from single sample sets in a high-throughput laboratory environment.
SCIEX OS software
SCIEX OS software is an all-in-one software solution for forensic toxicology screening that lets you acquire, process and analyze data and even generate reports in the same software environment. It enables streamlined data processing of challenging forensic data sets with integrated tools to increase confidence in your results.
Forensic HR-MS/MS spectral library 2.1
Confirm identification of commonly tested drugs and metabolites using the Forensic HR-MS/MS spectral library. Containing over 1,740 forensic drugs and metabolites, this high-resolution library enables fast processing of targeted and non-targeted screening data for accurate compound identification from complex biological samples.
Sensitive and accurate quantitation workflows to monitor levels of performance-enhancing substances
The ability to accurately quantify performance-enhancing drugs and their metabolites is critical for detering their use by athletes. Anti-doping laboratories need robust and sensitive instrumentation that is capable of monitoring low levels of prohibited substances in human biological samples. Our nominal mass spectrometers provide the highest levels of quantitative performance for confirmation workflows. SCIEX Triple Quad and QTRAP systems are tailored to help you achieve the levels of sensitivity and selectivity you need to meet anti-doping laboratory requirements and budget with confidence.
High-sensitivity detection of forensic drug panel in human whole blood
The SCIEX 7500 system is a robust quantitative platform with exceptional performance in speed, linear dynamic range and sensitivity. Discover how an optimized method was used with this system for the accurate quantitation of a panel of 49 drugs in human whole blood with lower limits of quantitation in the sub-ng/mL to pg/mL range. The method was shown to maximize sensitivity while retaining the required levels of accuracy and performance.
High-sensitivity drug analysis using dried blood spots
There is increasing interest in using dried blood spots for toxicology applications, such as drug monitoring. Here, the SCIEX 7500 system was used to quantify a panel of 24 drugs and metabolites in dried blood spots. The extraction method was optimized to maximize the analyte extraction recovery across the broad panel. Lower limits of quantitation ranging from 5 to 250 pg/mL were obtained with the required levels of accuracy and performance. The SCIEX 7500 system was shown to have the sensitivity and robustness required for the suite of drugs targeted in this study.
Leveraging sensitivity improvements for low-level detection of drugs, metabolites, and endogenous hormones in complex biological matrices
The technological innovations included in the SCIEX 7500 system can be leveraged to improve the sensitivity and overall quantitation performance of a number of challenging forensic and clinical workflows. See how using the SCIEX 7500 system enabled improvements in both lower limits of detection and quantitation, which provided the ability to routinely and robustly detect ultra-low levels of analytes extracted from challenging biological matrices.
Rapid and sensitive analysis of a 93-compound forensic Panel in urine using the QTRAP/Triple Quad 4500 LCMS/MS system
In this work, an optimized and sensitive method is described for the detection of 93 drugs and metabolites in human urine using the QTRAP 4500 system. The combination of a dilute-and-shoot sample preparation procedure and an optimized Scheduled MRM algorithm enabled rapid and sensitive detection of these substances with lower limits of quantitation in the sub-ng/mL to pg/mL range while maintaining excellent linearity, precision and accuracy.
Forensic toxicology
Whether you need to comprehensively screen for drugs, confirm and quantify them, identify unknown substances or characterize new and emerging drugs, SCIEX has a solution that meets your most demanding requirements.
Homeland security
Detecting trace levels of seized drugs, chemical warfare agents, explosives or illicit materials requires high-throughput and sensitive instrumentation. SCIEX has an extensive portfolio of LC-MS/MS systems that provide the evidence required by the forensic and security communities.
Cannabis and hemp potency testing
The diversity of cannabis and hemp products makes accurate potency testing difficult. SCIEX provides sensitive, accurate and precise instrumentation capable of differentiating legalized hemp products from controlled cannabis. Where such use is permitted under local state or country law, forensic labs can now test with the highest confidence.