Learn how to streamline the detection of environmental contaminants in biological specimens with LC-MS/MS so you can confidently assess their impact on human health.
PFAS biomonitoring
Biomonitoring PFAS levels in biological matrices
Per- and polyfluoroalkyl substances (PFAS) are a class of pervasive environmental contaminants used in a variety of industrial applications and found in a wide range of consumer products, such as cookware, stain repellants and coatings. The proliferation of PFAS in the environment due to anthropogenic activities, along with their inability to break down naturally, has resulted in widespread contamination, growing concerns about their potential health risks and an increased interest in PFAS monitoring. LC-MS/MS provides the sensitivity, speed and confidence required to accurately quantify and identify these contaminants. Whether you are using nominal mass instruments for targeted analysis or accurate mass instruments to identify unknown compounds, such as biological interferences, with non-targeted analysis, LC-MS/MS enables more confident identification and better quantitative performance with higher sensitivity and specificity than previously used techniques.
Nominal mass resources for PFAS quantitation in biological matrix
Leverage our experience with PFAS testing to reliably biomonitor low levels of PFAS and assess the impact of these bioaccumulating substances on human health. Learn how the robustness and sensitivity of our nominal mass platforms enable researchers to accurately quantify low levels of PFAS in complex biological matrices.
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Technical note
Rapid LC-MS/MS method for monitoring bio-relevant levels of per- and polyfluoroalkyl substances (PFAS) in serum
A targeted quantitative workflow for the analysis of 22 PFAS in serum enabled accurate quantitation of sub-nanogram per mL levels of PFAS in the human body using the QTRAP 6500+ system.
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Technical note
People & PFAS: quantitation in human serum and blood using volumetric absorptive microsampling (VAMS)
Trace-level analysis of PFAS was achieved using only 60 µL of whole blood collected with volumetric absorptive microsampling (VAMS) devices using the SCIEX 7500 system.
Nominal mass LC-MS/MS solutions for PFAS testing
SCIEX 7500+ system
Experience sensitive and robust quantitation that allows you to quantify bio-relevant levels of PFAS in biological matrices with reduced risk of downtime.
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QTRAP system
Explore revolutionary sensitivity, speed and performance for your most challenging methods. Enable scan functions that can identify, quantify and characterize all at once.
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SCIEX OS software
Unleash the analytical power of a next-generation software platform for data acquisition and processing.
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Accurate mass resources for PFAS quantitation in biological matrix
SCIEX has a proven record of providing comprehensive solutions for PFAS testing. Learn how accurate mass spectrometry can improve your PFAS analysis with improved mass resolution of endogenous interferences and confident identification using library-matching workflows.
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Technical note
PFAS identification in serum and plasma using data-independent acquisition and MS/MS library matching
Description An unbiased and non-targeted workflow using the SCIEX QTOF X500R system with automatic library matching enabled confident identification of PFAS in human serum and plasma. The SCIEX QTOF X500R system enabled mass resolution of PFOS and PFHxS from serum interferences, which were characterized using their fragmentation patterns and comparison with MS/MS libraries.
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Technical note
Reducing PFAS interferences during human plasma and serum analysis with accurate mass spectrometry
The SCIEX QTOF X500R system enabled mass resolution of PFOS and PFHxS from serum interferences, which were characterized using their fragmentation patterns and comparison with MS/MS libraries.
Accurate mass LC-MS/MS solutions for PFAS testing
X500R QTOF system
Benefit from an easy-to-use mass spectrometry system that analyzes data faster through the power of data-independent acquisition (DIA) with SWATH DIA.
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SCIEX OS software
Unleash the analytical power of a next-generation software platform for data acquisition and processing.
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Additional PFAS resources
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Webinar
PFAS testing: finding PFAS in people
Get an overview of strategies for accurately measuring low levels of PFAS in biological matrices using LC-MS/MS. Learn about sources of PFAS in the body, which PFAS are present in humans and how to monitor PFAS concentration in biological fluids to gauge their bioaccumulation in the body and overall impact on human health.
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Webinar
The exposome of PFAS
In this webinar, 2 subject matter experts share their insights on the detection of PFAS in humans. Discover strategies you can implement in your laboratory to accurately biomonitor low levels of PFAS to better understand the risks and toxicity associated with human exposure.
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