The Power of Precision
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Advance your research with front-end
instruments designed to help you realize the full power of your mass
spectrometer. SCIEX has the broadest portfolio of ESI-MS front-ends
can facilitate various flow rates, sample requirements and
sensitivities. No one else offers the entire range
flow, microflow, nanoflow LC-MS and even ultra-low flow
ExionLC 2.0 series
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Differential mobility spectrometry (DMS) and
ion mobility spectrometry are analytical techniques used to separate
ions based on their gas phase mobility. Multiple types of ion
devices exist, such as drift tubes, traveling wave, and high-field
asymmetric waveform devices. Learn how you can separate yourself
Differential Ion Mobility.
The latest ion sources from SCIEX enable
enhanced sensitivity and robustness with greater desolvation range
across all MS platforms, from Triple Quad to QTRAP and QTOF.
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and personal care products (PPCPs)
and protein bioanalysis
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and non-targeted screening data on your complex samples, faster and
easier than ever before.
All in one
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with best-in-class hardware, software and support all integrate to
revolutionize your lab.
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Nucleic Acid and Plasmid Analysis
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Oligonucleotides are exploding as a therapeutic modality. The ability of oligonucleotide therapies to modulate disease mechanisms at the messenger RNA (mRNA) level opens up the potential to treat pathologies previously considered “undruggable.”
The molecular properties of oligonucleotides place them somewhere between small molecules and protein therapeutics. SCIEX recognizes the special analytical challenges that oligonucleotide therapeutics present to scientists. We have partnered with scientists in the pharmaceutical and biopharmaceutical industries to develop precise, sensitive and efficient analytical solutions to help enable your investigational new drug (IND) or new drug application (NDA) programs.
Many existing oligonucleotide assays can be too rigid to adapt when problems arise. Explore flexible and compliant data analysis options that give you complete information from a single injection.
Oligonucleotide quantitation and characterization by high resolution LC-MS
Understanding oligonucleotides from every angle: utilizing mass spectrometry for characterization and quantification
High resolution LC-MS/MS solutions for oligonucleotides
Discover a solution that provides extreme negative ion mode sensitivity and detection. Benefit from fewer required experiments, faster candidate selection and shorter development time.
Improve sensitivity for antisense oligonucleotide quantification in plasma using microLC-MRM methodology
Sensitive quantification of therapeutic oligonucleotides extracted from plasma
Approaches for quantification of oligonucleotides in extracted plasma using high resolution mass spectrometry
Full length and truncated oligonucleotides with ligand binding assay formats are difficult to distinguish. With high resolution MS and MS/MS solutions, you can confirm the mass of full length and clipped or truncated oligonucleotides with confidence.
High resolution analysis of synthetic oligonucleotides
Analysis of locked nucleic acid (LNA) oligonucleotides (ON) and related impurities using accurate mass spectrometry
Metabolite ID and relative quantification of oligonucleotides in plasma
Characterization of oligonucleotides and related impurities to support the development of drug substances
Development of an ultra-sensitive assay for anti-sense oligonucleotide quantification
The market-leading negative ion performance across our mass spectrometry portfolio delivers extreme sensitivity for your most challenging therapeutic oligonucleotides. You will see not only a boost in sensitivity with microflow chromatography, but also a decrease in system contamination and downtime for cleaning. Confidently run your analyses with the ease of connecting SCIEX sources and employing instrumentation designed specifically for microflow.
Discover the power of Zeno trap pulsing with EAD fragmentation technology in this high-resolution accurate mass system.
Start detecting the previously undetectable and quantify at lower level with impressive precision.
Great negative ion mode performance with the ability to simultaneously quantify both analytes and metabolites.
Excellent negative ion mode performance ensures high sensitivity for the lowest levels of oligonucleotide qualification.
Experience the intelligent union of high sensitivity, ease of use and robustness to quantify oligonucleotides.
This compliant-ready solution is optimized for qualitative and quantitative data analysis.
Determine impurities and biotransformations for a wide variety of therapeutic molecules with highly accurate and flexible workflows.
Automatically deconvolute multiply-charged ESI/LC/MS mass spectra from a wide variety of biomolecules.
As the technologies for manufacturing and analysis of gene therapy products continue to evolve, it’s important to keep up with industry trends and analytical advancements. This compendium can help you advance your gene therapies and oligonucleotide therapeutics to the next level with the latest tools and methods.
Whether you need high sensitivity for quantification or to characterize impurities and catabolites, SCIEX has complete end-to-end solutions for fast, easy and confident LC-MS oligonucleotide analysis.
The destination for all your support needs