- Productos de ciencias biológicas e investigación para espectrometría de masas
- iMethod Application for Bisphenol Octylphenol and Nonylphenol for Cliquid Software
The Power of Precision
Bisphenol A (BPA) is widely used in high-production volume manufacturing of polycarbonate plastics and epoxy resins. Current studies evaluating the impact of BPA on health and the environment have not reported conclusive results. Octylphenol (OP) and nonylphenol (NP) are degradation products of alkylphenol ethoxylates, a family of nonionic surfactants widely used in consumer and institutional cleaning products. The estrogenic and toxic effects of OP and NP have been well-studied and reported.
By using ultra high performance Rapid Separation (RS) LC-MS/MS, BPA, OP and NP in water samples can be analyzed much more rapidly than using a labor intensive sample derivatization GC-MS method. This RSLC-MS/MS method has a significantly shorter run time of just 5 minutes compared to 25 minutes using GCMS technology, and uses a small particle size 2.2µm analytical column to provide robust and reproducible high throughput analysis.
Method files (ZIP)
|Activity||Using an iMethod™ Application||Traditional Method Development|
|Complete Test Protocol Documentation||Included||Weeks–Months|
|Sample Prep Techniques||Included, with examples and references||Weeks–Months|
|Optimized MS/MS Acquisition Parameters||Included||Weeks–Months|
|LC Instrument Parameters with Retention Times||Included||Days–Weeks|
|Integration (Quantitation) Parameters||Included||Days|
|LC/MS/MS Library Spectra||May be included. Stand-alone libraries are also available.||Weeks–Months|
|Staff Training – Software||Simple Cliquid® Software interface, no additional training||Traditional MS Software and review procedures – Days|
|Method Validation||Weeks. Validation templates and support available||Weeks–Months|
|Complete Test Development and Deployment||Weeks||6–12 months|