Exploring challenging molecules, compounds and solutions in analytical quantitation

Big challenges bring big opportunities. For companies and individuals pushing the boundaries of analytical quantitation, tackling complex problems can deliver exceptional rewards. That’s the driving force behind our Spotlight On series—a monthly feature that shines a light on some of the most demanding molecules and compound classes in the field. And recently, this series has expanded to software and technology solutions that enable progress in understanding these analytical challenges.

Each edition explores a different analytical challenge and introduces advanced LC-MS solutions designed for unmatched sensitivity and precision—helping you meet today’s requirements and prepare for tomorrow’s breakthroughs. So far, we’ve taken deep dives into nitrosamines, targeted protein degraders (TPDs), lipid mediators, PFAS (poly-and perfluoroalkyl substances), fentanyl, bile acids, GLP-1, oligonucleotides, SCIEX OS software and most recently cyclic peptides.

PFAS are often associated with long-chain “forever chemicals,” but growing concern is shifting to ultrashort-chain PFAS. With just 1–3 fully fluorinated carbons, these compounds are highly water soluble, mobile, and persistent — allowing them to travel far through water, soil, and agricultural systems. Understanding PFAS minis requires sensitive, selective analysis. Discover how SCIEX LC MS/MS workflows are helping labs detect and monitor ultrashort-chain PFAS across matrices in this month’s Spotlight On series. Log-in to learn more.

These brief, focused learning sessions are a quick read, designed to help learners gain a deeper understanding of each molecule and the role of LC-MS in their research and analysis.