Exploring challenging molecules, compounds and solutions in analytical quantitation

Big challenges bring big opportunities. For companies and individuals pushing the boundaries of analytical quantitation, tackling complex problems can deliver exceptional rewards. That’s the driving force behind our Spotlight On series—a monthly feature that shines a light on some of the most demanding molecules and compound classes in the field. And recently, this series has expanded to software and technology solutions that enable progress in understanding these analytical challenges.

Each edition explores a different analytical challenge and introduces advanced LC-MS solutions designed for unmatched sensitivity and precision—helping you meet today’s requirements and prepare for tomorrow’s breakthroughs. So far, we’ve taken deep dives into nitrosamines, targeted protein degraders (TPDs), lipid mediators, PFAS (poly-and perfluoroalkyl substances), fentanyl, bile acids, GLP-1, oligonucleotides, SCIEX OS software and most recently cyclic peptides.

For the next Spotlight on topic, we explore Mass Guard technology. As labs push for ever‑lower quantitation limits in complex matrics and high‑throughput workflows, increasing ion transmission can also increase contamination—putting signal integrity, uptime, and productivity at risk. Sensitivity only delivers value when systems stay clean, stable, and online, even with challenging “dirty” matrices. Mass Guard technology reduces the risk and frequency of instrument contamination, and keeps your lab moving forward. Log-in to learn more.

These brief, focused learning sessions are a quick read, designed to help learners gain a deeper understanding of each molecule and the role of LC-MS in their research and analysis.