Redefine your high-throughput analysis
New system now available:
Echo® MS+ system with ZenoTOF 8600 system
Combining high data quality and high-throughput analysis
When the quantity of samples is your challenge, breakthrough with the Echo® MS+ system. The Echo® MS+ system gives you high-quality data, analytical flexibility and high sample throughput so you can make informed decisions, today. With sampling rates of up to 1 sample per second, results can be generated on the same day. The Echo® MS+ system is a complete solution that removes bottlenecks in high-throughput analytical workflows, from sample preparation to data reporting.
Choose the right Echo® MS+ system for your laboratory
The Echo® MS+ system is available in three configurations:
- Echo® MS+ system with SCIEX Triple Quad 6500+ system
- Echo® MS+ system with ZenoTOF 7600 system
- Echo® MS+ system with ZenoTOF 8600 system
offering you the flexibility to meet the needs of your laboratory.
TECHNOLOGY
How AEMS takes your analysis to the new level
The Echo® MS+ system uses Acoustic Ejection Mass Spectrometry (AEMS). Samples are placed into compatible microtiter plates that are held in the Echo® MS+ system autosampler. Here, sound energy is applied to the bottom of each well individually. The sound energy causes reproducible droplets to be ejected from the well for capture in a carrier solvent of the OPI for dilution and transfer to the mass spectrometer source. From this point, the diluted sample is ionized using conventional electrospray ionization, making it ready for detection.
Redefining high-throughput mass spectrometry
Quality
Deliver high-quality data, minimize sample handling and eliminate carry over with contactless acoustic ejection sampling. Retain the precise, information-rich data needed to make informed decisions about your samples.
Precision
Achieve unparalleled standards of quantitation and qualification, at speed. The Echo® MS+ system provides consistency and precision in challenging matrices. Its high specificity enables confidence in results, and both decreases the need for re-runs and saves on reagent costs when compared to other technologies.
Speed
Conquer throughput barriers and decrease overall turnaround time with sampling speeds of up to 1 sample per second. Screen substrate and product simultaneously and reduce the number of analytical steps in your process.
THE SYSTEM
The Echo® MS+ system in your lab
BENEFITS
Redefining high-throughput quan/qual workflows
01.
The Echo® MS+ system is compatible with either the SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system for trusted mass spectrometry performance.
02.
Sample ejection allows for rapid sampling and reduced carryover.
03.
The system is compatible with robotic automation systems—automating steps such as sample preparation, plate preparation, plate loading/unloading, and plate submission for analysis.
04.
The port wash allows for cleaning the electrode assembly between sample plates, increasing the number of ejections that generate high quality data before you need to manually replace consumables.
05.
The new features of SCIEX OS software allow:
- Enhanced solvent and additive options for analytical flexibility
- Data acquisition modes to enable robust quantitative and qualitative capability
- The ability to analyze samples directly from a DMSO matrix
Echo® MS+ system walkthrough
01.
Method setup is both simple and fast. With data acquisition taking as little as 1 sample per second, you can quickly test many options for ideal settings.
02.
The MS method is similar to standard MS systems, with parameters such as mass range or MRM transition needing to be defined. SCIEX OS software users will be familiar with this step.
03.
Acquire and process your data in SCIEX OS software, simplifying your workflows and empowering swift, well-informed decision-making.
04.
See the process from beginning to end
Featured resources
Technical note
Elevating sensitivity for high-throughput intact protein analysis by HRMS
Discover a high throughput method for intact protein analysis using the Echo® MS+ system with ZenoTOF 8600. The enhanced sensitivity and throughput support the growing demands of protein based therapeutic and vaccine development, where rapid, multicomponent analysis is essential. The platform offers a faster, lower consumption alternative to traditional LC MS for large scale screening workflows.
Technical note
Maximizing speed and sensitivity in drug discovery
This technical note highlights sensitive small molecule quantitation in microsomal stability matrices using the Echo® MS+ system with ZenoTOF 8600, achieving up to an eightfold improvement in LLOQ across 13 compounds compared with the ZenoTOF 7600.
Flyer
Analytical solution for drug discovery assays
Selecting the right analytical technology to support drug discovery is a key decision. This infographic compares different analytical technologies in this space.
Technical note
Automated, rapid method optimization and buffer screening
Discover an efficient method development approach for the analysis of small molecules and intact proteins by mass spectrometry, in biologically relevant buffers.
Technical note
Determine optimal buffer concentration and compatibility for high-throughput intact protein analysis
Learn about how the Echo® MS+ system can be used to screen 9 sample concentrations in 16 different buffers in approximately 11 minutes.
Technical note
High-resolution, specific analysis of arginine and citrulline
Read about how the Echo® MS+ system can rapidly quantify both arginine and citrulline in a single analysis with minimal sample preparation.
Technical note
Optimizing robustness for high-throughput screening
Learn more about system settings to optimize method robustness for optimum long-term performance.
Infographic
Set high-quality mass spectrometry to warp speed
Learn how to accelerate your drug discovery with innovative mass spectrometry solution.
Related topics
ZenoTOF 7600 system
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
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SCIEX Triple Quad 6500+ system
Delivering a balance of speed, performance, and sensitivity for your most challenging analytes.
Learn more
High-throughput mass spectrometry
Screen thousands of candidates for desirable drug properties and process data with confidence, faster. Get the information you need to make go/no-go decisions quickly in the drug discovery phase of your work.
Learn more
ZenoTOF 8600 system
The newest accurate mass platform with sensitivity levels up to 10x greater than existing SCIEX technology. This translates not only into the lower limits of quantitation but also into new enabled approaches to making biologically relevant discoveries that can be proved by the data.
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SCIEX OS software
The next generation of operating system for enhanced LC-MS/MS analysis. It’s available on our compact, easy-to-use, high resolution, accurate mass X-series QTOF systems.
Learn more