iMethod™ Application for Benzodiazepines Version 1.2 for Cliquid® Software
For research use only. Not for use in diagnostic procedures.
The SCIEX iMethod Application for benzodiazepines enables you to be up and running quickly with preconfigured settings and report templates specific for the quantification of 30 benzodiazepines and non-benzodiazepine hypnotics (zaleplon, zolpidem, zopiclone) in plasma, blood, or urine.
Included with this method are: a Restek 5µm PFP Propyl pre-column (60 Å, 10 x 2.1 mm) and Restek 5µm PFP Propyl analytical column (60 Å, 50 x 2.1 mm).
Just download a method, add your sample, and you're ready to go
iMethod Applications for forensic toxicology provide instant LC-MS/MS methods, enabling you to generate accurate and precise results faster. Simply download a lab-proven method from the web or a CD into Cliquid Software and run your sample. All the instrument parameters are downloaded upon installation. Everything you need to start running a test immediately is included: sample preparation protocols, optimized MS and LC parameters, integration parameters, reporting templates, and documentation.
Quantification of 30 benzodiazepines in plasma, blood, or urine
Benzodiazepines and other non-benzodiazepine hypnotics, such as zaleplon, zolpidem, and zopiclone are widely prescribed psychoactive drugs for the treatment of anxiety and sleep disorders. Frequently, these substances lead to dependence and abuse, and some can affect judgment and behavior. As a result, these compounds are of great interest to forensic and clinical toxicology laboratories. The iMethod™ Application quantifies benzodiazepines in plasma, blood, or urine. Example sample preparation procedures are provided, based upon the sample matrix type and degree of clean-up required. Sample preparations range from a simple extraction and dilution for urine to liquid-liquid extraction for blood and plasma to solid phase extraction for plasma and urine. Diazepam-d5 and doxepin-d3 are used as internal standards.
The iMethod Application for benzodiazepines is configured for use on the SCIEX Technologies 3200 and 4000 Series instruments.
The list of available iMethod™ Applications located in the iMethod Store is continually updated with the newest user-contributed and SCIEX lab-proven methods, so you can take immediate advantage of the latest advances. All iMethod™ Applications are available for individual purchase or as part of one of our complete starter packs for forensic toxicology.
Reduce development time
Using an iMethod Application
Traditional Method Development
Complete Test Protocol Documentation
Sample Prep Techniques
Included, with examples and references
Optimized MS/MS Acquisition Parameters
LC Instrument Parameters with Retention Times
Integration (Quantitation) Parameters
LC/MS/MS Library Spectra
May be included. Stand-alone libraries are also available.
Staff Training – Software
Simple Cliquid® Software interface, no additional training
Traditional MS Software and review procedures – Days
Weeks. Validation templates and support available
Complete Test Development and Deployment