Address the unexpected in cell line development
Learn how to accelerate characterization of post translational modifications that impact product quality.
Kristen Nields, PhD
Senior Scientist Johnson & Johnson Innovative Medicine
Guide decisions during cell line development with charge variant identification at the intact level.
Understanding and quantifying the charge heterogeneity profile of a biotherapeutic is necessary to setting specifications to demonstrate process robustness and to support regulatory findings.
Characterization of a biopharmaceutical intensified process utilizing icIEF-UV/MS to quantify advanced glycation end products as a source of color
Join the discussion in this webinar and probe the cause of color change in a protein therapeutic. Learn how a cell line development group is utilizing the integrated icIEF-UV/MS workflow to monitor these events for product release.
Reduce risk in mAb development with the Intabio ZT system
Learn how to optimize monoclonal antibody (mAb) development and achieve confident characterization of mAbs using icIEF-UV/MS to improve product quality and manufacturing efficiency.
Andrew J. Mahan, PhD
Mass Spec group leader Johnson & Johnson Innovative Medicine
Learn about the link between AGE formation and color change in final drug products
Because a product quality attribute (PQA) may impact efficacy and safety, the color of a protein therapeutic under process development, and any changes to that color require close monitoring.
Defining PQAs linked to color change in a biotherapeutic during process development
This webinar discusses the use of a LC-MS workflow for detailed peptide mapping of PTMs.
Streamline PQA identification and peak integration with an EAD-based MAM workflow
Achieve confident identification and a streamlined multiple attribute methodology (MAM) workflow to monitor the many changes of glycation and advanced glycation end products (AGEs) in antibody-based therapeutics.
Other resources that might be of interest to you:
Intabio ZT system
Charge ahead with charge variant analysis and proteoform identification in minutes on a single platform.
Charge heterogeneity applications page
Pursue the end goal with confidence. Achieve the full picture and accelerate decisions with comprehensive characterization of biopharmaceutical charge variants.