- Productos de ciencias biológicas e investigación para espectrometría de masas
- vMethod Application for Bioanalytical Studies of Glucagon in Human Plasma Using LC-MS
The Power of Precision
For research use only. Not for use in diagnostic procedures.
Glucagon (a polypeptide hormone) plays a key role in treating severe hypoglycemia. It is a single chain polypeptide that contains 29 amino acid residues. Typically, bioanalysis of Glucagon, like most other biologics, is performed by ligand binding assays, however, such assays can suffer from cross-reactivity issues and lack of standardization. LC-MS/MS offers some significant advantages in developing universal, robust, sensitive, and reproducible assays with shorter developmental times. In addition, LC-MS/MS can distinguish between closely related species, metabolites, or endogenous interferences. SCIEX users can implement this method readily and avoid long method development times for biologics.
Reduce development time
|Activity||Using an iMethod Application||Traditional Method Development|
|Complete Test Protocol Documentation||Included||Weeks—Months|
|Sample Prep Techniques||Included||Weeks—Months|
|Optimized MS/MS Acquisition Parameters||Included||Days—Weeks|
|LC Instrument Parameters with Retention Times||Included||Days|
|Complete test Development and Deployment||Included|